Results 41 to 50 of about 103,226 (265)
Deubiquitination and Activation of the NLRP3 Inflammasome by UCHL5 in HCV-Infected Cells
Microbiology Spectrum, 2021 Chronic hepatitis C virus (HCV) infection induces liver inflammation that can lead to fibrosis, cirrhosis, and hepatocellular carcinoma (HCC). Inflammation is the outcome of the action of proinflammatory cytokines and chemokines, including interleukin-1 ...
Akshaya Ramachandran +3 more
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Distinct Molecular Mechanisms Underlying Potassium Efflux for NLRP3 Inflammasome Activation
Frontiers in Immunology, 2020 The NLRP3 inflammasome is a core component of innate immunity, and dysregulation of NLRP3 inflammasome involves developing autoimmune, metabolic, and neurodegenerative diseases.
Ziwei Xu +5 more
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ASN Neuro, 2021 Cerebrovascular diseases are pathological conditions involving impaired blood flow in the brain, primarily including ischaemic stroke, intracranial haemorrhage, and subarachnoid haemorrhage.
Rongrong Bai +5 more
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Journal of Experimental Medicine, 2018 In this issue of JEM, Boucher et al. (https://doi.org/10.1084/jem.20172222) report isolation of active caspase-1 from macrophages after inflammasome activation. Surprisingly, they find that caspase-1 is quickly inactivated upon autoproteolytic processing.
Sandstrom, Andrew, Vance, Russell E
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Mycobacterium tuberculosis and the host cell inflammasome: a complex relationship.
Frontiers in Cellular and Infection Microbiology, 2013 The production of IL-1β during the infection with Mycobacterium tuberculosis (Mtb) is important for successful host immune defense. In macrophages and dendritic cells the host cell inflammasome is crucial for generation of secreted IL-1β in response to ...
Volker eBriken +2 more
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Molecular Aspects of Medicine, 2022 Two decades of inflammasome research has led to a vast body of knowledge on the complex regulatory mechanisms and pathological roles of canonical and non-canonical inflammasome activation in a plethora of research models of primarily rodent origin. More recently, the field has made notable progress in characterizing human-specific inflammasomes and ...
Paerewijck, Oonagh, Lamkanfi, Mohamed
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The CARD8 T60 variant associates with NLRP1 and negatively regulates its activation
Frontiers in Immunology, 2022 The NLRP1 inflammasome functions as canonical cytosolic sensor in response to intracellular infections and is implicated in auto-inflammatory diseases. But the regulation and signal transduction mechanisms of NLRP1 are incompletely understood.
Zhihao Xu +17 more
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Inflammasomes and Their Activation [PDF]
Critical Reviews™ in Immunology, 2010 The innate immune system relies on the recognition of pathogens by pattern recognition receptors as a first line of defense and to initiate the adaptive immune response. Substantial progress has been made in defining the role of Nod (nucleotide-binding oligimerization domain)-like receptors and AIM2 (absent in melanoma 2) as pattern recognition ...
Sonal, Khare +3 more
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Anthrax and the inflammasome [PDF]
Microbes and Infection, 2012 Anthrax lethal toxin (LT), a major virulence determinant of anthrax disease, induces vascular collapse in mice and rats. LT activates the Nlrp1 inflammasome in macrophages and dendritic cells, resulting in caspase-1 activation, IL-1β and IL-18 maturation and a rapid cell death (pyroptosis).
Mahtab, Moayeri +2 more
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The International Journal of Biological Markers, 2022 Background The NLRP3 inflammasome is significantly associated with tumor development and metastasis in various malignancies. However, the significance of the NLRP3 inflammasome in pancreatic adenocarcinoma has not been fully determined. Therefore, we try
Lina Zheng, Hailiang Liu
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