Results 41 to 50 of about 119,990 (313)

ASC filament formation serves as a signal amplification mechanism for inflammasomes [PDF]

, 2016
A hallmark of inflammasome activation is the ASC speck, a micrometre-sized structure formed by the inflammasome adaptor protein ASC (apoptosis-associated speck-like protein containing a CARD), which consists of a pyrin domain (PYD) and a caspase ...
Hiller, Sebastian, Broz, Petr, Dick, Mathias S., Rühl, Sebastian, Sborgi, Lorenzo   +4 more
core   +1 more source

NLRP3 phosphorylation in its LRR domain critically regulates inflammasome assembly

, 2021
International audienceAbstract NLRP3 controls the secretion of inflammatory cytokines IL-1β/18 and pyroptosis by assembling the inflammasome. Upon coordinated priming and activation stimuli, NLRP3 recruits NEK7 within hetero-oligomers that nucleate ASC ...
Visvikis, Orane, Ricci, Roméo, Py, Bénédicte, Rey, Amaury, Lagrange, Brice, Niu, Tingting, Wong, Jeimin, Groslambert, Marine, Walker, Olivier, Wang, Ping, Chautard, Séverine, Henry, Thomas, Zhang, Zhirong, de Rosny, Charlotte, Patoli, Danish, Hologne, Maggy, Cosson, Camille, Hacot, Sabine, Petrilli, Virginie, Boyer, Laurent   +19 more
core   +1 more source

Of inflammasomes and pathogens – sensing of microbes by the inflammasome

EMBO Molecular Medicine, 2013
Inflammasomes are signalling platforms that sense a diverse range of microbial products and also a number of stress and damage associated endogenous signals. Inflammasome complexes can be formed by members of the Nod-like receptor family or the PYHIN family member AIM2.
Franz Bauernfeind, Veit Hornung
openaire   +3 more sources

Inflammasome Inhibitors [PDF]

Molecules, 2021
In recent years, the interplay between the activation of the immune system, the development of chronic inflammation and the onset and progression of many different diseases has been studied extensively [...]
openaire   +3 more sources

AP-1 signaling pathway promotes pro-IL-1β transcription to facilitate NLRP3 inflammasome activation upon influenza A virus infection

Virulence, 2022
NLRP3 inflammasome mainly controls interleukin-1β (IL-1β) secretion, leading to cell death called pyroptosis constituting a major antiviral host defense and inflammatory diseases upon viral infection.
Pin Wan, Simeng Zhang, Zhihui Ruan, Xueli Liu, Ge Yang, Yaling Jia, Yongkui Li, Pan Pan, Wenbiao Wang, Geng Li, Xulin Chen, Zhixin Liu, Qiwei Zhang, Zhen Luo, Jianguo Wu   +14 more
doaj   +1 more source

Lentinan from shiitake selectively attenuates AIM2 and non-canonical inflammasome activation while inducing pro-inflammatory cytokine production

Scientific Reports, 2017
Lentinan extracted from shiitake (Lentinula edodes) is a β-glucan that has been reported as an intravenous anti-tumor polysaccharide via enhancement of the host immune system. In this study, we determined the effect of lentinan on inflammasome activation,
Huijeong Ahn, Eunsaem Jeon, Jin-Chul Kim, Seung Goo Kang, Sung-il Yoon, Hyun-Jeong Ko, Pyeung-Hyeun Kim, Geun-Shik Lee   +7 more
doaj   +1 more source

Inflammasomes in the lung

Molecular Immunology, 2017
Innate immune responses act as first line defences upon exposure to potentially noxious stimuli. The innate immune system has evolved numerous intracellular and extracellular receptors that undertake surveillance for potentially damaging particulates.
Pinkerton, James W., Kim, Richard Y., Robertson, Avril A. B., Hirota, Jeremy A., Wood, Lisa G., Knight, Darryl A., Cooper, Matthew A., O'Neill, Luke A. J., Horvat, Jay C., Hansbro, Philip M.   +9 more
openaire   +6 more sources

Inflammasomes and autoimmunity [PDF]

Trends in Molecular Medicine, 2011
The NOD-like receptor (NLR) family members are cytosolic sensors of microbial components and danger signals. A subset of NLRs control inflammasome assembly that results in caspase-1 activation and, in turn, IL-1β and IL-18 production. Excessive inflammasome activation can cause autoinflammatory disorders, including the hereditary periodic fevers ...
Shaw, Patrick J., McDermott, Michael F., Kanneganti, Thirumala-Devi   +2 more
openaire   +2 more sources

Atheroma and the inflammasome [PDF]

Journal of Nuclear Cardiology, 2015
Atherosclerosis is a ubiquitous disorder that begins in childhood. An autopsy study of 2,876 adolescents and young adults (ages 15-34) who died of external causes found fatty streaks in the aorta of 100% of subjects, and in the right coronary artery in half the subjects. The number and extent of lesions increased with age.
openaire   +2 more sources

Deubiquitination and Activation of the NLRP3 Inflammasome by UCHL5 in HCV-Infected Cells

Microbiology Spectrum, 2021
Chronic hepatitis C virus (HCV) infection induces liver inflammation that can lead to fibrosis, cirrhosis, and hepatocellular carcinoma (HCC). Inflammation is the outcome of the action of proinflammatory cytokines and chemokines, including interleukin-1 ...
Akshaya Ramachandran, Binod Kumar, Gulam Waris, David Everly   +3 more
doaj   +1 more source