Results 41 to 50 of about 109,193 (265)
Ecotoxicology and Environmental Safety, 2021 Arsenic exposure is related to insulin resistance (IR). However, the underlying mechanism is still uncertain. NOD-like receptors containing pyrin domain 3 (NLRP3) inflammasome is a key driving factor of IR.
Jingyuan Zhang +12 more
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Inflammasomes and autoimmunity [PDF]
Trends in Molecular Medicine, 2011 The NOD-like receptor (NLR) family members are cytosolic sensors of microbial components and danger signals. A subset of NLRs control inflammasome assembly that results in caspase-1 activation and, in turn, IL-1β and IL-18 production. Excessive inflammasome activation can cause autoinflammatory disorders, including the hereditary periodic fevers ...
Shaw, Patrick J. +2 more
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C646 Protects Against DSS-Induced Colitis Model by Targeting NLRP3 Inflammasome
Frontiers in Pharmacology, 2021 Numerous pieces of evidence have identified that the NLRP3 inflammasome plays a pivotal role in the development and pathogenesis of colitis. Targeting the NLRP3 inflammasome represents a potential therapeutic treatment.
Xueming Xu +7 more
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The International Journal of Biological Markers, 2022 Background The NLRP3 inflammasome is significantly associated with tumor development and metastasis in various malignancies. However, the significance of the NLRP3 inflammasome in pancreatic adenocarcinoma has not been fully determined. Therefore, we try
Lina Zheng, Hailiang Liu
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Virulence, 2022 NLRP3 inflammasome mainly controls interleukin-1β (IL-1β) secretion, leading to cell death called pyroptosis constituting a major antiviral host defense and inflammatory diseases upon viral infection.
Pin Wan +14 more
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Complementing the inflammasome [PDF]
Immunology, 2016 SummaryThe innate immune system is an ancient surveillance system able to sense microbial invaders as well as aberrations in normal cell function. No longer viewed as a static and non‐specific part of immunity, the innate immune system employs a plethora of specialized pattern recognition sensors to monitor and achieve homeostasis; these include the ...
Martha, Triantafilou +3 more
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Scientific Reports, 2017 Lentinan extracted from shiitake (Lentinula edodes) is a β-glucan that has been reported as an intravenous anti-tumor polysaccharide via enhancement of the host immune system. In this study, we determined the effect of lentinan on inflammasome activation,
Huijeong Ahn +7 more
doaj +1 more source
ASN Neuro, 2021 Cerebrovascular diseases are pathological conditions involving impaired blood flow in the brain, primarily including ischaemic stroke, intracranial haemorrhage, and subarachnoid haemorrhage.
Rongrong Bai +5 more
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Molecular Aspects of Medicine, 2022 Two decades of inflammasome research has led to a vast body of knowledge on the complex regulatory mechanisms and pathological roles of canonical and non-canonical inflammasome activation in a plethora of research models of primarily rodent origin. More recently, the field has made notable progress in characterizing human-specific inflammasomes and ...
Paerewijck, Oonagh, Lamkanfi, Mohamed
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Journal of Experimental Medicine, 2018 In this issue of JEM, Boucher et al. (https://doi.org/10.1084/jem.20172222) report isolation of active caspase-1 from macrophages after inflammasome activation. Surprisingly, they find that caspase-1 is quickly inactivated upon autoproteolytic processing.
Sandstrom, Andrew, Vance, Russell E
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