Results 21 to 30 of about 163,829 (303)
The Role of the Inflammasome in Heart Failure
Frontiers in Physiology, 2021 Inflammation promotes the development of heart failure (HF). The inflammasome is a multimeric protein complex that plays an essential role in the innate immune response by triggering the cleavage and activation of the proinflammatory cytokines ...
Jimin Wu +15 more
doaj +1 more source
Cytoprotective Activated Protein C Averts Nlrp3 Inflammasome–Induced Ischemia-Reperfusion Injury Via Mtorc1 Inhibition [PDF]
, 2017 Cytoprotection by activated protein C (aPC) after ischemia-reperfusion injury (IRI) is associated with apoptosis inhibition. However, IRI is hallmarked by inflammation, and hence, cell-death forms disjunct from immunologically silent apoptosis are, in ...
Al-Dabet, Moh\u27d Mohanad +16 more
core +2 more sources
The mitochondrial protease HtrA2 restricts the NLRP3 and AIM2 inflammasomes. [PDF]
, 2018 Activation of the inflammasome pathway is crucial for effective intracellular host defense. The mitochondrial network plays an important role in inflammasome regulation but the mechanisms linking mitochondrial homeostasis to attenuation of inflammasome ...
Alnemri, Emad S. +9 more
core +4 more sources
Animals, 2020 Inflammation is critical for infection control and acts as an arsenal defense mechanism against invading microbes through activation of the host immune system.
Amin Tahoun +7 more
doaj +1 more source
TRPV1 channel mediates NLRP3 inflammasome-dependent neuroinflammation in microglia
Cell Death and Disease, 2021 Multiple sclerosis (MS) is a chronic inflammatory autoimmune disease in the central nervous system (CNS). The NLRP3 inflammasome is considered an important regulator of immunity and inflammation, both of which play a critical role in MS.
Yahui Zhang +13 more
doaj +1 more source
Frontiers in Pharmacology, 2021 The abnormal activation of the NLRP3 inflammasome is closely related to the occurrence and development of many inflammatory diseases. Targeting the NLRP3 inflammasome has been considered an efficient therapy to treat infections.
Ziying Wei +27 more
doaj +1 more source
Bone matrix components activate the NLRP3 inflammasome and promote osteoclast differentiation [PDF]
, 2017 The NLRP3 inflammasome senses a variety of signals referred to as danger associated molecular patterns (DAMPs), including those triggered by crystalline particulates or degradation products of extracellular matrix. Since some DAMPs confer tissue-specific
Abu-Amer, Yousef +9 more
core +2 more sources
Frontiers in Immunology, 2021 The dysregulation of NLRP3 inflammasome plays a critical role in pathogenesis of various human inflammatory diseases, thus NLRP3 inflammasome activation must be tightly controlled at multiple levels.
Tiantian Tang +6 more
doaj +1 more source
IKKα negatively regulates ASC-dependent inflammasome activation. [PDF]
, 2014 The inflammasomes are multiprotein complexes that activate caspase-1 in response to infections and stress, resulting in the secretion of pro-inflammatory cytokines.
Alnemri, Emad S +19 more
core +1 more source
Inflammasome Activation by ATP Enhances Citrobacter rodentium Clearance through ROS Generation
Cellular Physiology and Biochemistry, 2017 Background: Nod-like receptor family, pyrin domain containing 3 (NLRP3) is an important cytosolic sensor of cellular stress and infection. Once activated, NLRP3 forms a multiprotein complex (inflammasome) that triggers the maturation and secretion of ...
Michael Bording-Jorgensen +3 more
doaj +1 more source