Results 21 to 30 of about 119,990 (313)

Dihydrotanshinone I Specifically Inhibits NLRP3 Inflammasome Activation and Protects Against Septic Shock In Vivo

Frontiers in Pharmacology, 2021
The abnormal activation of the NLRP3 inflammasome is closely related to the occurrence and development of many inflammatory diseases. Targeting the NLRP3 inflammasome has been considered an efficient therapy to treat infections.
Ziying Wei, Ziying Wei, Xiaoyan Zhan, Xiaoyan Zhan, Kaixin Ding, Kaixin Ding, Guang Xu, Wei Shi, Lutong Ren, Lutong Ren, Zhie Fang, Tingting Liu, Xiaorong Hou, Jia Zhao, Hui Li, Hui Li, Jiayi Li, Jiayi Li, Zhiyong Li, Qiang Li, Li Lin, Yan Yang, Xiaohe Xiao, Xiaohe Xiao, Zhaofang Bai, Zhaofang Bai, Junling Cao, Junling Cao   +27 more
doaj   +1 more source

Double-walled carbon nanotubes trigger IL-1β release in human monocytes through Nlrp3 inflammasome activation [PDF]

, 2012
Because of their outstanding physical properties, carbon nanotubes (CNTs) are promising new materials in the field of nanotechnology. It is therefore imperative to assess their adverse effects on human health.
Dardenne, Christophe, Meunier, Etienne, Bernard Pipy, David Olagnier, José Bernad, Agnès Coste, Authier, Hélène, Emmanuel Flahaut, Béraud, Maryse, Bernad, José, Flahaut, Emmanuel, Etienne Meunier, Maryse Béraud, Pipy, Bernard, Lise Lefèvre, Christophe Dardenne, Coste, Agnès, Hélène Authier, Olagnier, David, Lefèvre, Lise   +19 more
core   +1 more source

TRPV1 channel mediates NLRP3 inflammasome-dependent neuroinflammation in microglia

Cell Death and Disease, 2021
Multiple sclerosis (MS) is a chronic inflammatory autoimmune disease in the central nervous system (CNS). The NLRP3 inflammasome is considered an important regulator of immunity and inflammation, both of which play a critical role in MS.
Yahui Zhang, Baohua Hou, Peiyu Liang, Xin Lu, Yifan Wu, Xinyi Zhang, Yuanteng Fan, Yumin Liu, Taoxiang Chen, Wanhong Liu, Biwen Peng, Jun Yin, Song Han, Xiaohua He   +13 more
doaj   +1 more source

Anti-GBM glomerulonephritis involves IL-1 but is independent of NLRP3/ASC inflammasome-mediated activation of caspase-1 [PDF]

, 2011
IL-1b and IL-18 are proinflammatory cytokines that contribute to renal immune complex disease, but whether IL-1b and IL-18 are mediators of intrinsic glomerular inflammation is unknown.
Volker Vielhauer, Clemens D Cohen, Vielhauer, V, Lichtnekert Julia, Dan Muruve, Shrikant R. Mulay, Muruve, D, Ramanjaneyulu Allam, Maja T. Lindenmeyer, Lichtnekert, Julia, Hans-Joachim Anders, Lindenmeyer, M T, Cohen Clemens D., Kulkarni, Onkar P., Vielhauer, Volker, Muruve Dan, Kulkarni Onkar P., Maja T Lindenmeyer, Cohen, Clemens D., Ryu, Mi, Rupanagudi Khader Valli, Ryu Mi, Khader Valli Rupanagudi, Mulay Shrikant R., Ryu, M, Lindenmeyer, Maja T., Anders Hans-Joachim, Clemens D. Cohen, Cohen, C D, Onkar P Kulkarni, Shrikant R Mulay, Allam, R, Allam Ramanjaneyulu, Vielhauer Volker, Muruve, Dan, Rupanagudi, Khader Valli, Anders, Hans-Joachim, Mi Ryu, Lichtnekert, J, Mulay, Shrikant R., Allam, Ramanjaneyulu, Julia Lichtnekert, Lindenmeyer Maja T., Rupanagudi, K V, Mulay, S R, Kulkarni, O P, Anders, H J, Onkar P. Kulkarni   +47 more
core   +1 more source

The Role of the Inflammasome in Heart Failure

Frontiers in Physiology, 2021
Inflammation promotes the development of heart failure (HF). The inflammasome is a multimeric protein complex that plays an essential role in the innate immune response by triggering the cleavage and activation of the proinflammatory cytokines ...
Jimin Wu, Jimin Wu, Jimin Wu, Jimin Wu, Erdan Dong, Erdan Dong, Erdan Dong, Erdan Dong, Youyi Zhang, Youyi Zhang, Youyi Zhang, Youyi Zhang, Han Xiao, Han Xiao, Han Xiao, Han Xiao   +15 more
doaj   +1 more source

Protective and Aggravating Effects of Nlrp3 Inflammasome Activation in IBD Models: Influence of Genetic and Environmental Factors [PDF]

, 2012
Background: Inflammatory bowel disease (IBD) is characterized by chronic intestinal inflammation due to dysregulation of the mucosal immune system.
Schnurr, M., Bauer, Christian, Düwell, Peter, Endres, S., Bauer, C., Duewell, P., Schnurr, Max, Lehr, Hans-Anton, Lehr, H.A., Endres, Stefan   +9 more
core   +1 more source

The E3 Ubiquitin Ligase TRIM65 Negatively Regulates Inflammasome Activation Through Promoting Ubiquitination of NLRP3

Frontiers in Immunology, 2021
The dysregulation of NLRP3 inflammasome plays a critical role in pathogenesis of various human inflammatory diseases, thus NLRP3 inflammasome activation must be tightly controlled at multiple levels.
Tiantian Tang, Ping Li, Xinhui Zhou, Rui Wang, Xiuqin Fan, Mengyi Yang, Kemin Qi   +6 more
doaj   +1 more source

Inflammasome Activation in Bovine Peripheral Blood-Derived Macrophages Is Associated with Actin Rearrangement

Animals, 2020
Inflammation is critical for infection control and acts as an arsenal defense mechanism against invading microbes through activation of the host immune system.
Amin Tahoun, Kirsty Jensen, Hanem El-Sharkawy, David Gally, Amira M. Rizk, Jamaan Ajarem, Ahmed Allam, Ayman M. Mahmoud   +7 more
doaj   +1 more source

Lactic Acid Fermentation Is Required for NLRP3 Inflammasome Activation

Frontiers in Immunology, 2021
Activation of the Nod-like receptor 3 (NLRP3) inflammasome is important for activation of innate immune responses, but improper and excessive activation can cause inflammatory disease.
Hsin-Chung Lin, Hsin-Chung Lin, Yu-Jen Chen, Yu-Jen Chen, Yu-Jen Chen, Yau-Huei Wei, Hsin-An Lin, Chien-Chou Chen, Tze-Fan Liu, Yi-Lin Hsieh, Kuo-Yang Huang, Kuan-Hung Lin, Hsueh-Hsiao Wang, Lih-Chyang Chen   +13 more
doaj   +1 more source

A role for uric acid and the nalp3 inflammasome in antiphospholipid antibody-induced IL-1β production by human first trimester trophoblast [PDF]

, 2013
Women with antiphospholipid syndrome (APS) are at risk of recurrent pregnancy loss and obstetrical disorders, such as preeclampsia and intrauterine growth restriction (IUGR).
Vikki M Abrahams, Kavathas, Paula B., Melissa J Mulla, Crina M Boeras, Mulla, Melissa J., Paula B Kavathas, Jan J Brosens, Brosens, Jan J., Boeras, Crina M., Larry W Chamley, Jane E Salmon, Abrahams, Vikki M., Salmon, Jane E., Chamley, Larry W.   +13 more
core   +1 more source