Results 21 to 30 of about 137,811 (315)

Enigmatic inflammasomes [PDF]

Immunology, 2021
SummaryInflammasomes are generally thought of as large protein complexes that assemble in the cytosol in response to danger such as tissue damage or infection; once activated, they trigger production of inflammatory cytokines and drive cells towards a pro‐inflammatory death – termed pyroptosis.
openaire   +2 more sources

Anti-GBM glomerulonephritis involves IL-1 but is independent of NLRP3/ASC inflammasome-mediated activation of caspase-1 [PDF]

, 2011
IL-1b and IL-18 are proinflammatory cytokines that contribute to renal immune complex disease, but whether IL-1b and IL-18 are mediators of intrinsic glomerular inflammation is unknown.
Volker Vielhauer, Clemens D Cohen, Vielhauer, V, Lichtnekert Julia, Dan Muruve, Shrikant R. Mulay, Muruve, D, Ramanjaneyulu Allam, Maja T. Lindenmeyer, Lichtnekert, Julia, Hans-Joachim Anders, Lindenmeyer, M T, Cohen Clemens D., Kulkarni, Onkar P., Vielhauer, Volker, Muruve Dan, Kulkarni Onkar P., Maja T Lindenmeyer, Cohen, Clemens D., Ryu, Mi, Rupanagudi Khader Valli, Ryu Mi, Khader Valli Rupanagudi, Mulay Shrikant R., Ryu, M, Lindenmeyer, Maja T., Anders Hans-Joachim, Clemens D. Cohen, Cohen, C D, Onkar P Kulkarni, Shrikant R Mulay, Allam, R, Allam Ramanjaneyulu, Vielhauer Volker, Muruve, Dan, Rupanagudi, Khader Valli, Anders, Hans-Joachim, Mi Ryu, Lichtnekert, J, Mulay, Shrikant R., Allam, Ramanjaneyulu, Julia Lichtnekert, Lindenmeyer Maja T., Rupanagudi, K V, Mulay, S R, Kulkarni, O P, Anders, H J, Onkar P. Kulkarni   +47 more
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Inflammasome Activation in Bovine Peripheral Blood-Derived Macrophages Is Associated with Actin Rearrangement

Animals, 2020
Inflammation is critical for infection control and acts as an arsenal defense mechanism against invading microbes through activation of the host immune system.
Amin Tahoun, Kirsty Jensen, Hanem El-Sharkawy, David Gally, Amira M. Rizk, Jamaan Ajarem, Ahmed Allam, Ayman M. Mahmoud   +7 more
doaj   +1 more source

C3a/C3aR synergies with TGF-β to promote epithelial-mesenchymal transition of renal tubular epithelial cells via the activation of the NLRP3 inflammasome

Journal of Translational Medicine, 2023
Background Complement component 3a and its receptor (C3a/C3aR) and the nucleotide-binding oligomerization domain-like receptor protein-3 (NLRP3) inflammasome contribute to epithelial-mesenchymal transition (EMT).
Danyu You, Kun Nie, Xiaoting Wu, Mengjie Weng, Liyan Yang, Yi Chen, Jiong Cui, Jianxin Wan   +7 more
doaj   +1 more source

The Role of the Inflammasome in Heart Failure

Frontiers in Physiology, 2021
Inflammation promotes the development of heart failure (HF). The inflammasome is a multimeric protein complex that plays an essential role in the innate immune response by triggering the cleavage and activation of the proinflammatory cytokines ...
Jimin Wu, Jimin Wu, Jimin Wu, Jimin Wu, Erdan Dong, Erdan Dong, Erdan Dong, Erdan Dong, Youyi Zhang, Youyi Zhang, Youyi Zhang, Youyi Zhang, Han Xiao, Han Xiao, Han Xiao, Han Xiao   +15 more
doaj   +1 more source

TRPV1 channel mediates NLRP3 inflammasome-dependent neuroinflammation in microglia

Cell Death and Disease, 2021
Multiple sclerosis (MS) is a chronic inflammatory autoimmune disease in the central nervous system (CNS). The NLRP3 inflammasome is considered an important regulator of immunity and inflammation, both of which play a critical role in MS.
Yahui Zhang, Baohua Hou, Peiyu Liang, Xin Lu, Yifan Wu, Xinyi Zhang, Yuanteng Fan, Yumin Liu, Taoxiang Chen, Wanhong Liu, Biwen Peng, Jun Yin, Song Han, Xiaohua He   +13 more
doaj   +1 more source

Protective and Aggravating Effects of Nlrp3 Inflammasome Activation in IBD Models: Influence of Genetic and Environmental Factors [PDF]

, 2012
Background: Inflammatory bowel disease (IBD) is characterized by chronic intestinal inflammation due to dysregulation of the mucosal immune system.
Schnurr, M., Bauer, Christian, Düwell, Peter, Endres, S., Bauer, C., Duewell, P., Schnurr, Max, Lehr, Hans-Anton, Lehr, H.A., Endres, Stefan   +9 more
core   +1 more source

Dihydrotanshinone I Specifically Inhibits NLRP3 Inflammasome Activation and Protects Against Septic Shock In Vivo

Frontiers in Pharmacology, 2021
The abnormal activation of the NLRP3 inflammasome is closely related to the occurrence and development of many inflammatory diseases. Targeting the NLRP3 inflammasome has been considered an efficient therapy to treat infections.
Ziying Wei, Ziying Wei, Xiaoyan Zhan, Xiaoyan Zhan, Kaixin Ding, Kaixin Ding, Guang Xu, Wei Shi, Lutong Ren, Lutong Ren, Zhie Fang, Tingting Liu, Xiaorong Hou, Jia Zhao, Hui Li, Hui Li, Jiayi Li, Jiayi Li, Zhiyong Li, Qiang Li, Li Lin, Yan Yang, Xiaohe Xiao, Xiaohe Xiao, Zhaofang Bai, Zhaofang Bai, Junling Cao, Junling Cao   +27 more
doaj   +1 more source

Inflammasomes and Cancer [PDF]

Cancer Immunology Research, 2017
Abstract Inflammation affects all stages of tumorigenesis. A key signaling pathway leading to acute and chronic inflammation is through activation of the caspase-1 inflammasome. Inflammasome complexes are assembled on activation of certain nucleotide-binding domain, leucine-rich repeat–containing proteins (NLR), AIM2-like receptors, or ...
Karki, Rajendra, Man, Si Ming, Kanneganti, Thirumala-Devi   +2 more
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Inflammasome Activation by ATP Enhances Citrobacter rodentium Clearance through ROS Generation

Cellular Physiology and Biochemistry, 2017
Background: Nod-like receptor family, pyrin domain containing 3 (NLRP3) is an important cytosolic sensor of cellular stress and infection. Once activated, NLRP3 forms a multiprotein complex (inflammasome) that triggers the maturation and secretion of ...
Michael Bording-Jorgensen, Misagh Alipour, Eytan Wine, Ghazal Danesh   +3 more
doaj   +1 more source