Results 11 to 20 of about 137,811 (315)
Mycobacterium tuberculosis and the host cell inflammasome: a complex relationship. [PDF]
Frontiers in Cellular and Infection Microbiology, 2013 The production of IL-1β during the infection with Mycobacterium tuberculosis (Mtb) is important for successful host immune defense. In macrophages and dendritic cells the host cell inflammasome is crucial for generation of secreted IL-1β in response to ...
Volker eBriken +2 more
doaj +2 more sources
Molecular Aspects of Medicine, 2020 Ketelut-Carneiro and Fitzgerald discuss the basic concepts about inflammasome composition, assembly and activation, effector functions and role in infection and inflammatory disease.
Natália, Ketelut-Carneiro +1 more
openaire +4 more sources
Cell, 2010 Inflammasomes are molecular platforms activated upon cellular infection or stress that trigger the maturation of proinflammatory cytokines such as interleukin-1beta to engage innate immune defenses. Strong associations between dysregulated inflammasome activity and human heritable and acquired inflammatory diseases highlight the importance this pathway
Schroder, Kate, Tschopp, Jurg
openaire +6 more sources
Cold Spring Harbor Perspectives in Biology, 2014 Inflammasomes are large cytosolic multiprotein complexes that assemble in response to detection of infection- or stress-associated stimuli and lead to the activation of caspase-1-mediated inflammatory responses, including cleavage and unconventional secretion of the leaderless proinflammatory cytokines IL-1β and IL-18, and initiation of an inflammatory
de Zoete, Marcel R +3 more
openaire +3 more sources
Induction of Inflammasome Activation in Macrophage Cells by Polyethyleneimine-Modified Graphene Oxide Nanoparticles [PDF]
, 2023 Vaccine development has been a cornerstone of modern medicine and the use of adjuvants in vaccine development has been a phenomenon present since the early 1900’s.
Lilly-Tariah, Ibinabo
core +1 more source
Inflammasomes, the eye and anti-inflammasome therapy [PDF]
Eye, 2017 Inflammasomes, key molecular regulators that play an important role in inflammation, consist of a central protein, an adaptor protein ASC (apoptosis speck-like protein) and a caspase-1 protein. Upon activation, caspase-1 induces maturation of cytokines such as interleukin-1β (IL-1β) and interleukin-18 (IL-18).
Yerramothu, P, Vijay, AK, Willcox, MDP
openaire +3 more sources
Immunology, 2020 Summary The NOD‐like receptor family pyrin domain containing 6 (NLRP6), a member of the NOD‐like receptor (NLR) family, acts as a cytosolic innate immune sensor that recognizes microbe‐associated molecular patterns. In some circumstances upon activation, NLRP6 recruits the adaptor apoptosis‐associated speck‐like protein (ASC) and the ...
Danping Zheng, Lara Kern, Eran Elinav
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Inflammasomes and Fibrosis [PDF]
Frontiers in Immunology, 2021 Fibrosis is the final common pathway of inflammatory diseases in various organs. The inflammasomes play an important role in the progression of fibrosis as innate immune receptors. There are four main members of the inflammasomes, such as NOD-like receptor protein 1 (NLRP1), NOD-like receptor protein 3 (NLRP3), NOD-like receptor C4 (NLRC4), and absent ...
Wen-Juan Zhang +5 more
openaire +3 more sources
Frontiers in Immunology, 2021 The dysregulation of NLRP3 inflammasome plays a critical role in pathogenesis of various human inflammatory diseases, thus NLRP3 inflammasome activation must be tightly controlled at multiple levels.
Tiantian Tang +6 more
doaj +1 more source
Double-walled carbon nanotubes trigger IL-1β release in human monocytes through Nlrp3 inflammasome activation [PDF]
, 2012 Because of their outstanding physical properties, carbon nanotubes (CNTs) are promising new materials in the field of nanotechnology. It is therefore imperative to assess their adverse effects on human health.
Dardenne, Christophe +19 more
core +1 more source