Results 31 to 40 of about 119,990 (313)
, 2023 Vaccine development has been a cornerstone of modern medicine and the use of adjuvants in vaccine development has been a phenomenon present since the early 1900’s.
Lilly-Tariah, Ibinabo
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Inflammasome Activation by ATP Enhances Citrobacter rodentium Clearance through ROS Generation
Cellular Physiology and Biochemistry, 2017 Background: Nod-like receptor family, pyrin domain containing 3 (NLRP3) is an important cytosolic sensor of cellular stress and infection. Once activated, NLRP3 forms a multiprotein complex (inflammasome) that triggers the maturation and secretion of ...
Michael Bording-Jorgensen +3 more
doaj +1 more source
Polyene macrolide antifungal drugs trigger interleukin-1β secretion by activating the NLRP3 inflammasome. [PDF]
, 2011 The use of antimycotic drugs in fungal infections is based on the concept that they suppress fungal growth by a direct killing effect. However, amphotericin and nystatin have been reported to also trigger interleukin-1β (IL-1β) secretion in monocytes but
Rupanagudi Khader Valli +15 more
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Inflammasomes and Cancer [PDF]
Cancer Immunology Research, 2017 Abstract Inflammation affects all stages of tumorigenesis. A key signaling pathway leading to acute and chronic inflammation is through activation of the caspase-1 inflammasome. Inflammasome complexes are assembled on activation of certain nucleotide-binding domain, leucine-rich repeat–containing proteins (NLR), AIM2-like receptors, or ...
Karki, Rajendra +2 more
openaire +3 more sources
Acta Pharmaceutica Sinica B, 2019 Aberrant activation of NLRP3 inflammasome has been implicated in the pathogenesis of diverse inflammation-related diseases, and pharmacological molecules targeting NLRP3 inflammasome are of considerable value to identifying potential therapeutic ...
Zhilei Wang +11 more
doaj +1 more source
EMBO Molecular Medicine, 2021 The inflammasome is a cytosolic multiprotein complex that plays a crucial role in inflammation and cell death. The sensor proteins in the inflammasome complex detect various microbial and endogenous stimuli, leading to subsequent caspase activation.
Daisuke Watanabe +2 more
doaj +1 more source
Ecotoxicology and Environmental Safety, 2021 Arsenic exposure is related to insulin resistance (IR). However, the underlying mechanism is still uncertain. NOD-like receptors containing pyrin domain 3 (NLRP3) inflammasome is a key driving factor of IR.
Jingyuan Zhang +12 more
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The double sides of NLRP3 inflammasome activation in sepsis
, 2023 International audienceAbstract Sepsis is defined as a life-threatening organ dysfunction induced by a dysregulated host immune response to infection. Immune response induced by sepsis is complex and dynamic.
Py, Bénédicte F. +3 more
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Cell Reports, 2019 Summary: The NLRP3 inflammasome is a cytosolic complex sensing phagocytosed material and various damage-associated molecular patterns, triggering production of the pro-inflammatory cytokines interleukin-1 beta (IL)-1β and IL-18 and promoting pyroptosis ...
Mark M. Hughes +22 more
doaj +1 more source
C646 Protects Against DSS-Induced Colitis Model by Targeting NLRP3 Inflammasome
Frontiers in Pharmacology, 2021 Numerous pieces of evidence have identified that the NLRP3 inflammasome plays a pivotal role in the development and pathogenesis of colitis. Targeting the NLRP3 inflammasome represents a potential therapeutic treatment.
Xueming Xu +7 more
doaj +1 more source