Results 31 to 40 of about 137,811 (315)

Lactic Acid Fermentation Is Required for NLRP3 Inflammasome Activation

Frontiers in Immunology, 2021
Activation of the Nod-like receptor 3 (NLRP3) inflammasome is important for activation of innate immune responses, but improper and excessive activation can cause inflammatory disease.
Hsin-Chung Lin, Hsin-Chung Lin, Yu-Jen Chen, Yu-Jen Chen, Yu-Jen Chen, Yau-Huei Wei, Hsin-An Lin, Chien-Chou Chen, Tze-Fan Liu, Yi-Lin Hsieh, Kuo-Yang Huang, Kuan-Hung Lin, Hsueh-Hsiao Wang, Lih-Chyang Chen   +13 more
doaj   +1 more source

A role for uric acid and the nalp3 inflammasome in antiphospholipid antibody-induced IL-1β production by human first trimester trophoblast [PDF]

, 2013
Women with antiphospholipid syndrome (APS) are at risk of recurrent pregnancy loss and obstetrical disorders, such as preeclampsia and intrauterine growth restriction (IUGR).
Vikki M Abrahams, Kavathas, Paula B., Melissa J Mulla, Crina M Boeras, Mulla, Melissa J., Paula B Kavathas, Jan J Brosens, Brosens, Jan J., Boeras, Crina M., Larry W Chamley, Jane E Salmon, Abrahams, Vikki M., Salmon, Jane E., Chamley, Larry W., Boeras Crina M., Chamley Larry W., Abrahams Vikki M., Mulla Melissa J., Salmon Jane E., Brosens Jan J., Kavathas Paula B.   +20 more
core   +2 more sources

inflammasome [PDF]

, 2023
Inflammasome signaling is a central pillar of innate immunity triggering inflammation and cell death in response to microbes and danger signals. Here, we show that two virulence factors from the human bacterial pathogen Clostridium perfringens are ...
Awad, MM, Man, SM, Ngo, C, Zhao, A, Lee, J, Kay, C, Lyras, D, Enosi Tuipulotu, D, Gardiner, EE, Feng, S, Shen, C, Xue, Y, Rug, M, Kaakoush, NO, Miosge, LA, Robertson, AA, Jing, W, Atmosukarto, II, Ali, SA, Price, JD, Mathur, A, Pandey, A, Lo Pilato, J, Nadeem O Kaakoush, Callum Kay, Anukriti Mathur, Dena Lyras, Yansong Xue, Elizabeth E Gardiner, Abhimanu Pandey, Cheng Shen, Jiwon Lee, Si Ming Man, Chinh Ngo, Sidra A Ali, Ines I Atmosukarto, Anyang Zhao, Lisa A Miosge, Milena M Awad, Melanie Rug, Jordan Lo Pilato, Avril AB Robertson, Weidong Jing, Shouya Feng, Jason D Price, Daniel Enosi Tuipulotu   +45 more
core   +2 more sources

Cardamonin from a medicinal herb protects against LPS-induced septic shock by suppressing NLRP3 inflammasome

Acta Pharmaceutica Sinica B, 2019
Aberrant activation of NLRP3 inflammasome has been implicated in the pathogenesis of diverse inflammation-related diseases, and pharmacological molecules targeting NLRP3 inflammasome are of considerable value to identifying potential therapeutic ...
Zhilei Wang, Guang Xu, Yuan Gao, Xiaoyan Zhan, Nan Qin, Shubin Fu, Ruisheng Li, Ming Niu, Jiabo Wang, Youping Liu, Xiaohe Xiao, Zhaofang Bai   +11 more
doaj   +1 more source

Interaction between the inflammasome and commensal microorganisms in gastrointestinal health and disease

EMBO Molecular Medicine, 2021
The inflammasome is a cytosolic multiprotein complex that plays a crucial role in inflammation and cell death. The sensor proteins in the inflammasome complex detect various microbial and endogenous stimuli, leading to subsequent caspase activation.
Daisuke Watanabe, Yijie Guo, Nobuhiko Kamada   +2 more
doaj   +1 more source

ASC filament formation serves as a signal amplification mechanism for inflammasomes [PDF]

, 2016
A hallmark of inflammasome activation is the ASC speck, a micrometre-sized structure formed by the inflammasome adaptor protein ASC (apoptosis-associated speck-like protein containing a CARD), which consists of a pyrin domain (PYD) and a caspase ...
Hiller, Sebastian, Broz, Petr, Dick, Mathias S., Rühl, Sebastian, Sborgi, Lorenzo, Dick MS, Broz P, Sborgi L, Rühl S, Hiller S   +9 more
core   +1 more source

NLRP3 phosphorylation in its LRR domain critically regulates inflammasome assembly

, 2021
International audienceAbstract NLRP3 controls the secretion of inflammatory cytokines IL-1β/18 and pyroptosis by assembling the inflammasome. Upon coordinated priming and activation stimuli, NLRP3 recruits NEK7 within hetero-oligomers that nucleate ASC ...
Visvikis, Orane, Ricci, Roméo, Py, Bénédicte, Rey, Amaury, Lagrange, Brice, Niu, Tingting, Wong, Jeimin, Groslambert, Marine, Walker, Olivier, Wang, Ping, Chautard, Séverine, Henry, Thomas, Zhang, Zhirong, de Rosny, Charlotte, Patoli, Danish, Hologne, Maggy, Cosson, Camille, Hacot, Sabine, Petrilli, Virginie, Boyer, Laurent, Py, Bénedicte F., De Rosny, C. (Charlotte), Chautard, S. (Séverine), Patoli, D. (Danish), Séverine Chautard, Niu, T. (Tingting), Sabine Hacot, Ricci, R. (Romeo), Cosson, C. (Camille), Boyer, L. (Laurent), Ping Wang, Visvikis, O. (Oriane), Bénédicte F. Py, Hacot, S. (Sabine), Amaury Rey, Jeimin Wong, Charlotte De Rosny, Marine Groslambert, Groslambert, M. (Marine), Henry, T. (Thomas), Camille Cosson, Petrilli, V. (Virginie), Tingting Niu, Laurent Boyer, Rey, A. (Amaury), Danish Patoli, Walker, O. (Olivier), Thomas Henry, Zhang, Z. (Zhirong), Brice Lagrange, Roméo Ricci, Olivier Walker, Wang, P. (Ping), Orane Visvikis, Maggy Hologne, Virginie Petrilli, Zhirong Zhang, Wong, J. (Jeimin), Hologne, M. (Maggy)   +58 more
core   +1 more source

Of inflammasomes and pathogens – sensing of microbes by the inflammasome

EMBO Molecular Medicine, 2013
Abstract Inflammasomes are signalling platforms that sense a diverse range of microbial products and also a number of stress and damage associated endogenous signals. Inflammasome complexes can be formed by members of the Nod‐like receptor family or the PYHIN family member AIM2.
Franz Bauernfeind, Veit Hornung
openaire   +4 more sources

Inflammasome Inhibitors [PDF]

Molecules, 2021
In recent years, the interplay between the activation of the immune system, the development of chronic inflammation and the onset and progression of many different diseases has been studied extensively [...]
openaire   +4 more sources

Polyene macrolide antifungal drugs trigger interleukin-1β secretion by activating the NLRP3 inflammasome. [PDF]

, 2011
The use of antimycotic drugs in fungal infections is based on the concept that they suppress fungal growth by a direct killing effect. However, amphotericin and nystatin have been reported to also trigger interleukin-1β (IL-1β) secretion in monocytes but
Rupanagudi Khader Valli, Khader Valli Rupanagudi, Allam, R., Anders Hans-Joachim, Darisipudi, M.N., Ramanjaneyulu Allam, Allam Ramanjaneyulu, Murthy Narayana Darisipudi, Hans-Joachim Anders, Rupanagudi, K.V., Rupanagudi, Khader Valli, Anders, Hans-Joachim, Anders, H.J., Darisipudi, Murthy Narayana, Darisipudi Murthy Narayana, Allam, Ramanjaneyulu   +15 more
core   +2 more sources