Results 31 to 40 of about 103,226 (265)
Cell Reports, 2019 Summary: The NLRP3 inflammasome is a cytosolic complex sensing phagocytosed material and various damage-associated molecular patterns, triggering production of the pro-inflammatory cytokines interleukin-1 beta (IL)-1β and IL-18 and promoting pyroptosis ...
Mark M. Hughes +22 more
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C646 Protects Against DSS-Induced Colitis Model by Targeting NLRP3 Inflammasome
Frontiers in Pharmacology, 2021 Numerous pieces of evidence have identified that the NLRP3 inflammasome plays a pivotal role in the development and pathogenesis of colitis. Targeting the NLRP3 inflammasome represents a potential therapeutic treatment.
Xueming Xu +7 more
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Of inflammasomes and pathogens – sensing of microbes by the inflammasome
EMBO Molecular Medicine, 2013 Abstract Inflammasomes are signalling platforms that sense a diverse range of microbial products and also a number of stress and damage associated endogenous signals. Inflammasome complexes can be formed by members of the Nod‐like receptor family or the PYHIN family member AIM2.
Franz Bauernfeind, Veit Hornung
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Molecules, 2021 In recent years, the interplay between the activation of the immune system, the development of chronic inflammation and the onset and progression of many different diseases has been studied extensively [...]
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Virulence, 2022 NLRP3 inflammasome mainly controls interleukin-1β (IL-1β) secretion, leading to cell death called pyroptosis constituting a major antiviral host defense and inflammatory diseases upon viral infection.
Pin Wan +14 more
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Molecular Immunology, 2017 Innate immune responses act as first line defences upon exposure to potentially noxious stimuli. The innate immune system has evolved numerous intracellular and extracellular receptors that undertake surveillance for potentially damaging particulates.
Pinkerton, James W. +9 more
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Inflammasomes and autoimmunity [PDF]
Trends in Molecular Medicine, 2011 The NOD-like receptor (NLR) family members are cytosolic sensors of microbial components and danger signals. A subset of NLRs control inflammasome assembly that results in caspase-1 activation and, in turn, IL-1β and IL-18 production. Excessive inflammasome activation can cause autoinflammatory disorders, including the hereditary periodic fevers ...
Shaw, Patrick J. +2 more
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Scientific Reports, 2017 Lentinan extracted from shiitake (Lentinula edodes) is a β-glucan that has been reported as an intravenous anti-tumor polysaccharide via enhancement of the host immune system. In this study, we determined the effect of lentinan on inflammasome activation,
Huijeong Ahn +7 more
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Atheroma and the inflammasome [PDF]
Journal of Nuclear Cardiology, 2015 Atherosclerosis is a ubiquitous disorder that begins in childhood. An autopsy study of 2,876 adolescents and young adults (ages 15-34) who died of external causes found fatty streaks in the aorta of 100% of subjects, and in the right coronary artery in half the subjects. The number and extent of lesions increased with age.
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Complementing the inflammasome [PDF]
Immunology, 2016 SummaryThe innate immune system is an ancient surveillance system able to sense microbial invaders as well as aberrations in normal cell function. No longer viewed as a static and non‐specific part of immunity, the innate immune system employs a plethora of specialized pattern recognition sensors to monitor and achieve homeostasis; these include the ...
Martha, Triantafilou +3 more
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