Results 51 to 60 of about 119,990 (313)
The NLRC4 inflammasome requires IRF8-dependent production of NAIPs [PDF]
, 2018 Activation of the NLRC4 inflammasome is crucial for defense against bacterial species that have flagellin or the type III secretion system (T3SS). We have discovered the role of interferon regulatory factor 8 (IRF8) in mediating NLRC4 inflammasome ...
Kanneganti, Thirumala-Devi +5 more
core +1 more source
Measurement of Cytosolic Mitochondrial DNA After NLRP3 Inflammasome Activation
, 2022 The NLRP3 inflammasome, a key component of the innate immune system that mediates caspase-1 activation, which in turn induces cleavage of the pyroptosis executioner gasdermin D and the proinflammatory cytokines IL-1β and IL-18, requires two signals to be
Traba, Javier +3 more
core +1 more source
Inflammasomes and Their Activation [PDF]
Critical Reviews™ in Immunology, 2010 The innate immune system relies on the recognition of pathogens by pattern recognition receptors as a first line of defense and to initiate the adaptive immune response. Substantial progress has been made in defining the role of Nod (nucleotide-binding oligimerization domain)-like receptors and AIM2 (absent in melanoma 2) as pattern recognition ...
Sonal, Khare +3 more
openaire +2 more sources
Distinct Molecular Mechanisms Underlying Potassium Efflux for NLRP3 Inflammasome Activation
Frontiers in Immunology, 2020 The NLRP3 inflammasome is a core component of innate immunity, and dysregulation of NLRP3 inflammasome involves developing autoimmune, metabolic, and neurodegenerative diseases.
Ziwei Xu +5 more
doaj +1 more source
Anthrax and the inflammasome [PDF]
Microbes and Infection, 2012 Anthrax lethal toxin (LT), a major virulence determinant of anthrax disease, induces vascular collapse in mice and rats. LT activates the Nlrp1 inflammasome in macrophages and dendritic cells, resulting in caspase-1 activation, IL-1β and IL-18 maturation and a rapid cell death (pyroptosis).
Mahtab, Moayeri +2 more
openaire +2 more sources
Role of mitochondrial K+ homeostasis in the control of the inflammatory process [PDF]
, 2023 openThe immune system defends the organism in different ways: one of these is innate immunity. In macrophages, the assembly of the NLRP3 inflammasome is a crucial step in the inflammation process: it mediates the release of different cytokines like Il-1β,
BOSCOLO MENEGUOLO, ALESSIO
core
Complementing the inflammasome [PDF]
Immunology, 2016 SummaryThe innate immune system is an ancient surveillance system able to sense microbial invaders as well as aberrations in normal cell function. No longer viewed as a static and non‐specific part of immunity, the innate immune system employs a plethora of specialized pattern recognition sensors to monitor and achieve homeostasis; these include the ...
Martha, Triantafilou +3 more
openaire +2 more sources
Molecular Aspects of Medicine, 2022 Two decades of inflammasome research has led to a vast body of knowledge on the complex regulatory mechanisms and pathological roles of canonical and non-canonical inflammasome activation in a plethora of research models of primarily rodent origin. More recently, the field has made notable progress in characterizing human-specific inflammasomes and ...
Paerewijck, Oonagh, Lamkanfi, Mohamed
openaire +3 more sources
Frontiers in Immunology, 2023 The NLRP3 inflammasome plays a critical role in the innate immune response, and its excessive activation will cause pyroptotic cell death and be associated with the onset of inflammatory diseases. However, NLRP3 inflammasome targeting therapies are still
Qianqian Di +8 more
doaj +1 more source
Mycobacterium tuberculosis and the host cell inflammasome: a complex relationship.
Frontiers in Cellular and Infection Microbiology, 2013 The production of IL-1β during the infection with Mycobacterium tuberculosis (Mtb) is important for successful host immune defense. In macrophages and dendritic cells the host cell inflammasome is crucial for generation of secreted IL-1β in response to ...
Volker eBriken +2 more
doaj +1 more source