Results 11 to 20 of about 1,017,988 (308)

Innate Immunity [PDF]

Journal of Allergy and Clinical Immunology, 2010
Innate immunity is an exciting area of research in rhinology because emerging evidence suggests that abnormal local immune responses, rather than pathogen-specific adaptive immunity, may play a more important role in the pathogenesis of chronic ...
Wormald, Peter John, Witterick, I., Ooi, E., Ooi, Eng Hooi, Eng H. Ooi, Psaltis, A., Witterick, Ian J, Peter-John Wormald, Alkis J. Psaltis, Wormald, P., Psaltis, Alkis, Ian J. Witterick   +11 more
core   +11 more sources

Innate immunity and neuroinflammation [PDF]

Mediators of Inflammation, 2013
Copyright © 2013 Abhishek Shastri et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly ...
Kishore, U, Domenico Marco Bonifati, Abhishek Shastri, Shastri, A, Bonifati, DM, Uday Kishore   +5 more
core   +6 more sources

Gasdermin D promotes hyperinflammation and immunopathology during severe influenza A virus infection

Cell Death and Disease, 2023
Excessive inflammation and tissue damage during severe influenza A virus (IAV) infection can lead to the development of fatal pulmonary disease. Pyroptosis is a lytic and pro-inflammatory form of cell death executed by the pore-forming protein gasdermin ...
Sarah Rosli, Christopher M. Harpur, Maggie Lam, Alison C. West, Christopher Hodges, Ashley Mansell, Kate E. Lawlor, Michelle D. Tate   +7 more
doaj   +1 more source

Nanobodies dismantle post‐pyroptotic ASC specks and counteract inflammation in vivo

EMBO Molecular Medicine, 2022
Inflammasomes sense intracellular clues of infection, damage, or metabolic imbalances. Activated inflammasome sensors polymerize the adaptor ASC into micron‐sized “specks” to maximize caspase‐1 activation and the maturation of IL‐1 cytokines.
Damien Bertheloot, Carlos WS Wanderley, Ayda H Schneider, Lisa DJ Schiffelers, Jennifer D Wuerth, Jan MP Tödtmann, Salie Maasewerd, Ibrahim Hawwari, Fraser Duthie, Cornelia Rohland, Lucas S Ribeiro, Lea‐Marie Jenster, Nathalia Rosero, Yonas M Tesfamariam, Fernando Q Cunha, Florian I Schmidt, Bernardo S Franklin   +16 more
doaj   +1 more source

Aggregated Hendra virus C-protein activates the NLRP3 inflammasome to induce inflammation

Journal of Inflammation, 2023
Background Hendra virus is an emerging virus with a geographically broad host reservoir. In humans, Hendra virus causes excessive inflammatory disease of the lung and nervous system. Our current understanding as to how Hendra virus or what factors induce
Kristian Barry, Christopher Harpur, Maggie Lam, Michelle D. Tate, Ashley Mansell   +4 more
doaj   +1 more source

Synthesis and validation of click-modified of NOD1/2 agonists [preprint] [PDF]

, 2023
This article is a preprint. Preprints are preliminary reports of work that have not been certified by peer review.NOD1 and NOD2 sense small bacterial peptidoglycan fragments often called muropeptides.
Silverman, Neal, Bharadwaj, Ravi, Brown, Ashley, Anonick, Madison V., Grimes, Catherine L., Wodzanowski, Kimberly A., Okuda, Kendi, Mashayekh, Siavash   +7 more
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Human rhinovirus promotes STING trafficking to replication organelles to promote viral replication

Nature Communications, 2022
Evidence exists that the typically antiviral signaling mediator STING is, counterintuitively, needed for optimal human rhinovirus infection. Here the authors confirm this finding and show how human rhinovirus can reduce stored Ca2+ levels to drive this ...
Martha Triantafilou, Joshi Ramanjulu, Lee M. Booty, Gisela Jimenez-Duran, Hakan Keles, Ken Saunders, Neysa Nevins, Emma Koppe, Louise K. Modis, G. Scott Pesiridis, John Bertin, Kathy Triantafilou   +11 more
doaj   +1 more source

Methotrexate suppresses psoriatic skin inflammation by inhibiting muropeptide transporter SLC46A2 activity [PDF]

, 2023
Cytosolic innate immune sensing is critical for protecting barrier tissues. NOD1 and NOD2 are cytosolic sensors of small peptidoglycan fragments (muropeptides) derived from the bacterial cell wall.
Nandy, Anubhab, Grimes, Catherine Leimkuhler, Kanneganti, Thirumala-Devi, Bharadwaj, Ravi, Wodzanowski, Kimberly A, Atukorale, Prabhani U, Orzalli, Megan H, Lusi, Christina F, Okuda, Kendi, Nagar, Abhinit, Anonick, Madison V, Silverman, Neal, Subbarao, Malireddi, Paik, Donggi, Kane, Griffin I, Monahan, Amanda, Brown, Ashley R, Goldman, William E, Mashayekh, Siavash   +18 more
core   +1 more source

Curating the innate immunity interactome [PDF]

, 2010
peer-reviewedBackground: The innate immune response is the first line of defence against invading pathogens and is regulated by complex signalling and transcriptional networks.
Laird, Matthew R, Anastasia Sribnaia, Winsor, Geoffrey L., Lynn, David J, Giselle Ring, Foroushani, Amir K., Laird, Matthew R., Que, Jaimmie, Geoffrey L Winsor, Robert EW Hancock, Sribnaia, Anastasia, Hancock, Robert E.W., Ring, Giselle, Melissa Yau, Fiona SL Brinkman, Calvin Chan, Jaimmie Que, David J Lynn, Brinkman, Fiona S. L., Naseer, Misbah, Matthew R Laird, Yau, Melissa, Lo, Raymond, Raymond Lo, Chan, Calvin, Wee, Kathleen, Winsor, Geoffrey L, Breuer, Karin, Kathleen Wee, Amir K Foroushani, Hancock, R. E. W. (Robert E. W.), Brinkman, Fiona S., Misbah Naseer, Karin Breuer, Lynn, David J., Hancock, Robert E W, Foroushani, Amir K, Brinkman, Fiona S L   +37 more
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InnateDB: systems biology of innate immunity and beyond—recent updates and continuing curation [PDF]

, 2012
peer-reviewedInnateDB (http://www.innatedb.com) is an integrated analysis platform that has been specifically designed to facilitate systems-level analyses of mammalian innate immunity networks, pathways and genes.
Brinkman, Fiona S. L., Laird, Matthew R, Amir K. Foroushani, David J. Lynn, Anastasia Sribnaia, Lynn, David J, Lo, Raymond, Raymond Lo, Foroushani, Amir K., Winsor, Geoffrey L, Breuer, Karin, Chen, Carol, Robert E. W. Hancock, Matthew R. Laird, Carol Chen, Geoffrey L. Winsor, Sribnaia, Anastasia, Hancock, Robert E.W., Karin Breuer, Fiona S. L. Brinkman   +19 more
core   +1 more source