Results 61 to 70 of about 473,545 (264)

HCV and innate immunity

Uirusu, 2008
Hepatitis C virus (HCV) is a single-strand, positive sense RNA virus belonging to the flaviviridae family. HCV develops persistent infection in >70% of infected patients, and eventually causes chronic hepatitis, cirrhosis, and hepatocellular carcinoma in some patients.
EBIHARA, Takashi, MATSUMOTO, Misako, SEYA, Tsukasa   +2 more
openaire   +3 more sources

Poxvirus dsDNA genomes differentially activate AIM2 or NLRP3 inflammasomes in human primary cells

The EMBO Journal
The innate immune system is known for its ability to recognize cytosolic DNA as evidence of infection, but detailed studies of this process have been mostly limited to mice and cell lines.
Yonas M Tesfamariam, Maria H Christensen, Stefan Diehl, Tabea Klein, Julius M Lingnau, Sabine Normann, Elena Hagelauer, Miriam Herbert, Sophie Reimer, Richa P Joshi, Pujan Engels, Steffen Pritzl, Pietro Fontana, Thomas Zillinger, Gunther Hartmann, Anna Eis-Hübinger, Martin C Lam, Klaus J Walgenbach, Felix Meissner, Hao Wu, Florian I Schmidt   +20 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Mosquito Innate Immunity [PDF]

Insects, 2018
Mosquitoes live under the endless threat of infections from different kinds of pathogens such as bacteria, parasites, and viruses. The mosquito defends itself by employing both physical and physiological barriers that resist the entry of the pathogen and the subsequent establishment of the pathogen within the mosquito.
Ankit Kumar, Priyanshu Srivastava, PDNN Sirisena, Sunil Kumar Dubey, Ramesh Kumar, Jatin Shrinet, Sujatha Sunil   +6 more
openaire   +3 more sources

A transient receptor potential vanilloid 1-dependent corneal–trigeminal neuroinflammatory circuit promotes corneal neuropathy

Experimental and Molecular Medicine
Corneal neurosensory abnormalities cause pain and discomfort in ocular surface disease, yet their pathophysiology is poorly understood. Here we show that in a mouse dry eye model, the ocular (over)activation of transient receptor potential vanilloid 1 ...
Manuela Pizzano, Alexia Vereertbrugghen, Maia J. Martinez Gomez, Juliana Bernatowiez, Douglas Vera Aguilar, Florencia Sabbione, Irene A. Keitelman, Federico Fuentes, Mirta N. Giordano, Analía S. Trevani, Jeremías G. Galletti   +10 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Innate immunity to pathogens [PDF]

Current Opinion in Immunology, 2008
The innate immune system is responsible for early detection and response to pathogens that then modulate subsequent immune responses [1]. A characteristic of innate immunity is the recognition of pathogen associated molecular patterns (PAMPs) by germline-encoded receptors such as the Toll-like receptors (TLRs) [2].
Wayne M, Yokoyama, Marco, Colonna
openaire   +2 more sources

Platelet transcription factors license the pro-inflammatory cytokine response of human monocytes

EMBO Molecular Medicine
In humans, blood Classical CD14+ monocytes contribute to host defense by secreting large amounts of pro-inflammatory cytokines. Their aberrant activity causes hyper-inflammation and life-threatening cytokine storms, while dysfunctional monocytes are ...
Ibrahim Hawwari, Lukas Rossnagel, Nathalia Rosero, Salie Maasewerd, Matilde B Vasconcelos, Marius Jentzsch, Agnieszka Demczuk, Lino L Teichmann, Lisa Meffert, Damien Bertheloot, Lucas S Ribeiro, Sebastian Kallabis, Felix Meissner, Moshe Arditi, Asli E Atici, Magali Noval Rivas, Bernardo S Franklin   +16 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Paneth cell α-defensin misfolding correlates with dysbiosis and ileitis in Crohn’s disease model mice

Life Science Alliance, 2020
This study provides novel insight into Crohn’s disease where α-defensin misfolding resulting from excessive ER stress in Paneth cells induces dysbiosis and disease progression.
Yu Shimizu, Kiminori Nakamura, Aki Yoshii, Yuki Yokoi, Mani Kikuchi, Ryuga Shinozaki, Shunta Nakamura, Shuya Ohira, Rina Sugimoto, Tokiyoshi Ayabe   +9 more
doaj   +1 more source