Results 61 to 70 of about 521,491 (212)
Uirusu, 2008 Hepatitis C virus (HCV) is a single-strand, positive sense RNA virus belonging to the flaviviridae family. HCV develops persistent infection in >70% of infected patients, and eventually causes chronic hepatitis, cirrhosis, and hepatocellular carcinoma in some patients.
EBIHARA, Takashi +2 more
openaire +3 more sources
Poxvirus dsDNA genomes differentially activate AIM2 or NLRP3 inflammasomes in human primary cells
The EMBO JournalThe innate immune system is known for its ability to recognize cytosolic DNA as evidence of infection, but detailed studies of this process have been mostly limited to mice and cell lines.
Yonas M Tesfamariam +20 more
doaj +1 more source
Innate Immunity to Adenovirus [PDF]
Human Gene Therapy, 2014 Human adenoviruses are the most widely used vectors in gene medicine, with applications ranging from oncolytic therapies to vaccinations, but adenovirus vectors are not without side effects. In addition, natural adenoviruses pose severe risks for immunocompromised people, yet infections are usually mild and self-limiting in immunocompetent individuals.
Hendrickx Rodinde +5 more
openaire +4 more sources
The influence of viral RNA secondary structure on interactions with innate host cell defences [PDF]
, 2013 RNA viruses infecting vertebrates differ fundamentally in their ability to establish persistent infections with markedly different patterns of transmission, disease mechanisms and evolutionary relationships with their hosts.
Blundell, Richard +13 more
core +1 more source
Experimental and Molecular MedicineCorneal neurosensory abnormalities cause pain and discomfort in ocular surface disease, yet their pathophysiology is poorly understood. Here we show that in a mouse dry eye model, the ocular (over)activation of transient receptor potential vanilloid 1 ...
Manuela Pizzano +10 more
doaj +1 more source
Platelet transcription factors license the pro-inflammatory cytokine response of human monocytes
EMBO Molecular MedicineIn humans, blood Classical CD14+ monocytes contribute to host defense by secreting large amounts of pro-inflammatory cytokines. Their aberrant activity causes hyper-inflammation and life-threatening cytokine storms, while dysfunctional monocytes are ...
Ibrahim Hawwari +16 more
doaj +1 more source
Die Another Way: Interplay between Influenza A Virus, Inflammation and Cell Death
Viruses, 2020 Influenza A virus (IAV) is a major concern to human health due to the ongoing global threat of a pandemic. Inflammatory and cell death signalling pathways play important roles in host defence against IAV infection.
Gabriel Laghlali +2 more
doaj +1 more source
Psoriasis: dysregulation of innate immunity
, 2005 The current understanding of the function of natural killer (NK) T cells in innate immunity and their potential to control acquired specific immunity, as well as the remarkable efficacy of antitumour necrosis factor-alpha biological treatments in ...
de Rie, M. A. +3 more
core +1 more source
SpermQ–A Simple Analysis Software to Comprehensively Study Flagellar Beating and Sperm Steering
Cells, 2018 Motile cilia, also called flagella, are found across a broad range of species; some cilia propel prokaryotes and eukaryotic cells like sperm, while cilia on epithelial surfaces create complex fluid patterns e.g., in the brain or lung.
Jan N. Hansen +3 more
doaj +1 more source
STAT3 serine phosphorylation is required for TLR4 metabolic reprogramming and IL-1β expression
Nature Communications, 2020 TLR4 signalling can reprogram the metabolism of macrophages to be more glycolytic and proinflammatory. Here the authors show that LPS and TLR4 signalling results in recruitment of TBK1, which in turn phosphorylates serine 727 on STAT3 to enable a ...
Jesse J. Balic +14 more
doaj +1 more source