Results 71 to 80 of about 521,491 (212)
Life Science Alliance, 2020 This study provides novel insight into Crohn’s disease where α-defensin misfolding resulting from excessive ER stress in Paneth cells induces dysbiosis and disease progression.
Yu Shimizu +9 more
doaj +1 more source
Toll-like Receptors and the Control of Immunity
, 2020 The study of innate immunity and its link to inflammation and host defense encompasses diverse areas of biology, ranging from genetics and biophysics to signal transduction and physiology.
Fitzgerald, Katherine A +1 more
core +1 more source
Hygiene hypothesis and innate immunity. evaluating the role of environmental factors and genetic polymorphisms on the expression of receptors of the innate immune system [PDF]
, 2009 Background In ‘westernised’ countries, the prevalence of childhood asthma and allergy has risen throughout the last few decades. A series of epidemiological studies showed reduced prevalence of asthma and allergy among farmers’ children compared to non ...
Bieli, Christian
core +1 more source
Interleukin-1β Signaling in Dendritic Cells Induces Antiviral Interferon Responses
mBio, 2018 Induction of interferon beta (IFN-β), IFN-stimulated genes (ISGs), and inflammatory responses is critical for control of viral infection. We recently identified an essential linkage of stimulation of the inflammatory cytokine interleukin-1β (IL-1β) and ...
Lauren D. Aarreberg +6 more
doaj +1 more source
Blockade of IL-33 release and suppression of type 2 innate lymphoid cell responses by helminth secreted products in airway allergy [PDF]
, 2014 Helminth parasites such as the nematode Heligmosomoides polygyrus strongly inhibit T helper type 2 (Th2) allergy, as well as colitis and autoimmunity. Here, we show that the soluble excretory/secretory products of H.
McSorley, H. J.; id_orcid +15 more
core +1 more source
Immunomodulatory Effects and Protection in Sepsis by the Antibiotic Moxifloxacin
AntibioticsSepsis is a leading cause of death in Intensive Care Units. Despite its prevalence, sepsis remains insufficiently understood, with no substantial qualitative improvements in its treatment in the past decades.
Tiago R. Velho +7 more
doaj +1 more source
Immunomodulation of Innate Immune Cells
, 2020 Activation of innate immune system underlies both pathological and physiological inflammatory responses and is critical for the host. Regulated innate immune response is thus essential not only for the elimination of invading pathogens but also for the ...
core +1 more source
Immunology Today, 2000 In a previous Comment1xPaternal leukocytes selectively increase secretion of IL-4 in peripheral blood during normal pregnancies (demonstrated by a novel one-way MLC measuring cytokine secretion) . Ekerfelt, C. et al. Am. J. Reprod. Immunol. 1997; 38: 320–326Crossref | PubMedSee all References, Ekerfelt et al.
Sacks, G, Sargent, I, Redman, C
openaire +2 more sources
Inflammatory caspases in innate immunity and inflammation.
, 2010 Caspases are best known for their role in apoptosis. More recently, they have gained prominence as critical mediators of innate immune responses. The so-called 'inflammatory caspases' include human caspase-1, -4, -5 and -12 and murine caspase-1, -11 and -
Drexler, S.K. +3 more
core +1 more source
“Cruising together”—ASC specks and SAA, a perfect match in chronic inflammation
EMBO Molecular MedicineCurrently, over 350 million people worldwide live with chronic inflammatory diseases, facing a range of complications that severely impact their quality of life.
Salie Maasewerd +1 more
doaj +1 more source