Results 91 to 100 of about 738,107 (298)

“Cruising together”—ASC specks and SAA, a perfect match in chronic inflammation

EMBO Molecular Medicine
Currently, over 350 million people worldwide live with chronic inflammatory diseases, facing a range of complications that severely impact their quality of life.
Salie Maasewerd, Bernardo Simoes Franklin   +1 more
doaj   +1 more source

A Helicobacter pylori Homolog of Eukaryotic Flotillin Is Involved in Cholesterol Accumulation, Epithelial Cell Responses and Host Colonization

Frontiers in Cellular and Infection Microbiology, 2017
The human pathogen Helicobacter pylori acquires cholesterol from membrane raft domains in eukaryotic cells, commonly known as “lipid rafts.” Incorporation of this cholesterol into the H. pylori cell membrane allows the bacterium to avoid clearance by the
Melanie L. Hutton, Kimberley D'Costa, Amanda E. Rossiter, Lin Wang, Lorinda Turner, David L. Steer, Seth L. Masters, Ben A. Croker, Maria Kaparakis-Liaskos, Richard L. Ferrero, Richard L. Ferrero   +10 more
doaj   +1 more source

Current Status of Defensins and Their Role in Innate and Adaptive Immunity [PDF]

, 2002
Naturally occurring antimicrobial cationic polypeptides play a major role in innate and adaptive immunity. These polypeptides are found to be either linear and unstructured or structured through disulfide bonds.
Dentino, Andrew R., Raj, Periathamby A.
core   +1 more source

The essential role of mitochondrial dynamics in antiviral immunity. [PDF]

, 2018
Viruses alter cellular physiology and function to establish cellular environment conducive for viral proliferation. Viral immune evasion is an essential aspect of viral persistence and proliferation.
Ahn, Dae-Gyun, Kim, Seong-Jun, Siddiqui, Aleem, Syed, Gulam H   +3 more
core   +2 more sources

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Helicobacter pylori VacA Suppresses Lactobacillus acidophilus-Induced Interferon Beta Signaling in Macrophages via Alterations in the Endocytic Pathway

mBio, 2013
Helicobacter pylori causes chronic gastritis and avoids elimination by the immune system of the infected host. The commensal bacterium Lactobacillus acidophilus has been suggested to exert beneficial effects as a supplement during H.
Gudrun Weiss, Sam Forster, Aaron Irving, Michelle Tate, Richard L. Ferrero, Paul Hertzog, Hanne Frøkiær, Maria Kaparakis-Liaskos   +7 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Disruption of myelin structure and oligodendrocyte maturation in a macaque model of congenital Zika infection

Nature Communications
Zika virus (ZikV) infection during pregnancy can cause congenital Zika syndrome (CZS) and neurodevelopmental delay in infants, of which the pathogenesis remains poorly understood.
Jennifer Tisoncik-Go, Caleb Stokes, Leanne S. Whitmore, Daniel J. Newhouse, Kathleen Voss, Andrew Gustin, Cheng-Jung Sung, Elise Smith, Jennifer Stencel-Baerenwald, Edward Parker, Jessica M. Snyder, Dennis W. Shaw, Lakshmi Rajagopal, Raj P. Kapur, Kristina M. Adams Waldorf, Michael Gale   +15 more
doaj   +1 more source

A Th2 Cytokine Profile in Appendicular Lavage Fluid Suggests Allergy as a Possible Etiology for Acute Appendicitis

Mediators of Inflammation, 2019
Acute appendicitis is the most frequent surgical abdominal emergency, but its etiology remains poorly understood. Histological examination of the appendix, following its removal due to acute appendicitis, consistently shows features in common with ...
Nuno Carvalho, André Barros, Hélder O. Coelho, Catarina F. Moita, Ana Neves-Costa, Dora Pedroso, Filipe C. Borges, Luís F. Moita, Paulo M. Costa   +8 more
doaj   +1 more source

Trained immunity or tolerance : opposing functional programs induced in human monocytes after engagement of various pattern recognition receptors [PDF]

, 2014
Article Accepted Date: 29 January 2014. ACKNOWLEDGMENTS D.C.I. received funding from the European Union's Seventh Framework Programme (FP7/2007-2013) under grant agreement HEALTH-2010-260338 (“Fungi in the setting of inflammation, allergy and autoimmune ...
Gow, Neil A R, Ifrim, Daniela C, Jacobs, Cor, Jacobs, Liesbeth, Jansen, Trees, Joosten, Leo A B, Netea, Mihai G, Quintin, Jessica, van der Meer, Jos W M, Williams, David L   +9 more
core   +4 more sources