Results 41 to 50 of about 521,465 (311)
An insight into the diverse roles of surfactant proteins, SP-A and SP-D in innate and adaptive immunity [PDF]
, 2012 PMCID: PMC3369187Surfactant proteins SP-A and SP-D are hydrophilic, collagen-containing calcium-dependent lectins, which appear to have a range of innate immune functions at pulmonary as well as extrapulmonary sites. These proteins bind to target ligands
Kishore, U +10 more
core +1 more source
Nature CommunicationsInflammasome activation results in the cleavage of gasdermin D (GSDMD) by pro-inflammatory caspases. The N-terminal domains (GSDMDNT) oligomerize and assemble pores penetrating the target membrane.
Lisa D. J. Schiffelers +13 more
doaj +1 more source
Nature Communications, 2022 Innate lymphoid cells (ILC) are effector cells that rapidly respond to immune evading stimuli, and despite their functional diversity arise from common precursors.
Carys A. Croft +9 more
doaj +1 more source
mBio, 2023 Influenza A virus (IAV) triggers multiple programmed cell death pathways, including MLKL-dependent necroptosis, caspase-8-dependent apoptosis, and caspase-1-dependent pyroptosis in myeloid cells.
Xuqiu Lei +3 more
doaj +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Gasdermin E deficiency limits inflammation and lung damage during influenza virus infection
Cell Death and DiseaseSevere influenza A virus (IAV) infections are associated with hyperinflammation and significant lung damage. Gasdermin E (GSDME) mediates pyroptosis, a lytic and inflammatory type of cell death.
Sarah Rosli +9 more
doaj +1 more source
RIG-I-like receptors direct inflammatory macrophage polarization against West Nile virus infection
Nature Communications, 2019 RIG-I- like receptors (RLRs) play an important role in immune defense against West Nile virus (WNV). Here, using a systems biology approach, the authors show that macrophage polarization to a proinflammatory M1 phenotype via RIG-I and MDA5 signaling is ...
Amy E. L. Stone +4 more
doaj +1 more source
Innate immunity and coagulation [PDF]
Journal of Thrombosis and Haemostasis, 2011 Infection frequently elicits a coagulation response. Endotoxin triggers the formation of tissue factor initiating coagulation, down regulates anticoagulant mechanisms including the protein C pathway and heparin-like proteoglycans and up regulates plasminogen activator inhibitor. The overall physiological result of this is to promote coagulation through
C T, Esmon, J, Xu, F, Lupu
openaire +2 more sources
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Key Roles of MiT Transcription Factors in Innate Immunity and Inflammation
, 2020 Microphthalmia/TFE (MiT) transcription factors (TFs), such as transcription factor EB (TFEB) and transcription factor E3 (TFE3), are emerging as key regulators of innate immunity and inflammation.
Irazoqui, Javier E
core +1 more source