Results 41 to 50 of about 524,193 (311)

An ocular Th1 immune response promotes corneal nerve damage independently of the development of corneal epitheliopathy

Journal of Neuroinflammation, 2023
Proper sight is not possible without a smooth, transparent cornea, which is highly exposed to environmental threats. The abundant corneal nerves are interspersed with epithelial cells in the anterior corneal surface and are instrumental to corneal ...
Alexia Vereertbrugghen, Manuela Pizzano, Florencia Sabbione, Irene Angelica Keitelman, Carolina Maiumi Shiromizu, Douglas Vera Aguilar, Federico Fuentes, Cintia S. de Paiva, Mirta Giordano, Analía Trevani, Jeremías G. Galletti   +10 more
doaj   +1 more source

Aging and Innate Immunity [PDF]

Immunity, 2006
Adaptive immunity undergoes severe deterioration with age and represents the main problem in the elderly. However, evidence accumulated over the last decade supports the hypothesis that aging also has a profound impact on innate immunity, which in turn markedly impacts the health and longevity of older people.
Solana, Rafael, Pawelec, Graham, Tarazona, Raquel   +2 more
openaire   +2 more sources

Marginal zone B cells: virtues of innate-like antibody-producing lymphocytes [PDF]

, 2013
Protective responses to microorganisms involve the nonspecific but rapid defence mechanisms of the innate immune system, followed by the specific but slow defence mechanisms of the adaptive immune system. Located as sentinels at the interface between the
Cols, M, Cerutti, A, Andrea Cerutti, Puga, I, Montserrat Cols, Irene Puga   +5 more
core   +1 more source

Targeting RIP Kinases in Chronic Inflammatory Disease

Biomolecules, 2021
Chronic inflammatory disorders are characterised by aberrant and exaggerated inflammatory immune cell responses. Modes of extrinsic cell death, apoptosis and necroptosis, have now been shown to be potent drivers of deleterious inflammation, and mutations
Mary Speir, Tirta M. Djajawi, Stephanie A. Conos, Hazel Tye, Kate E. Lawlor   +4 more
doaj   +1 more source

Western lifestyle linked to maladaptive trained immunity

eLife
Trained immunity (TI) refers to a state of innate immune cells that, after encountering an initial stimulus and undergoing epigenetic reprogramming and metabolic changes, allows them to respond more effectively to a subsequent challenge.
Aurelia Josephine Merbecks, Christabel Mennicken, Dennis Marinus de Graaf, Kateryna Shkarina, Theresa Wagner, Eicke Latz   +5 more
doaj   +1 more source

Metabolomic Profiling Reveals Distinct and Mutual Effects of Diet and Inflammation in Shaping Systemic Metabolism in Ldlr^−/− Mice

Metabolites, 2020
Changes in modern dietary habits such as consumption of Western-type diets affect physiology on several levels, including metabolism and inflammation. It is currently unclear whether changes in systemic metabolism due to dietary interventions are long ...
Mario A. Lauterbach, Eicke Latz, Anette Christ   +2 more
doaj   +1 more source

Innate Immunity in Disease [PDF]

Clinical Gastroenterology and Hepatology, 2014
Cells can innately recognize generic products of viruses, bacteria, fungi, or injured tissue by engagement of pattern recognition receptors. Innate immune cells rapidly respond to this engagement to control commensals, thwart pathogens, and/or prompt repair. Insufficient or excessive activation of the innate immune response results in disease.
David E, Elliott, Sana S, Siddique, Joel V, Weinstock   +2 more
openaire   +2 more sources

Expression of genes related to anti-inflammatory pathways are modified among farmers' children [PDF]

, 2014
The hygiene hypothesis states that children exposed to higher loads of microbes such as farmers' children suffer less from allergies later in life. Several immunological mechanisms underpinning the hygiene hypothesis have been proposed such as a shift in
Loeliger, Susanne, Roduit, Caroline; https://orcid.org/, van Hage, Marianne, Göran Pershagen, Sennhauser, Felix, Lauener, Roger P., Remo Frei, Marianne van Hage (91132), IRAS RATIA2, Felix Sennhauser, Susanne Loeliger (254440), von Mutius, Erika, Erika von Mutius (105805), Caroline Roduit (254441), Gert Doekes (397763), as part of the Parsifal study team,, Christian Bieli (531936), Waser, Marco, Cezmi A Akdis, Christian Bieli, Mutius, Erika von, Annika Scheynius, Roduit, Caroline, Riedler, Josef, Göran Pershagen (147977), LS IRAS EEPI GRA (Gezh.risico-analyse), Braun-Fahrländer, Charlotte, Remo Frei (254425), Roger P. Lauener (254451), Caroline Roduit, Akdis, Cezmi A, Risk Assessment of Toxic and Immunomodulatory Agents, Lauener, Roger P, Cezmi A. Akdis (187641), Akdis, Cezmi A., Marco Waser, Pershagen, Göran, Erika von Mutius, Doekes, Gert, Gert Doekes, Felix Sennhauser (531938), Josef Riedler, Susanne Loeliger, Charlotte Braun-Fahrländer, Hage, Marianne van, Frei, Remo, Scheynius, Annika, as part of the PARSIFAL study team, Roger P Lauener, Annika Scheynius (31954), Josef Riedler (194501), Charlotte Braun-Fahrländer (18248), Bieli, Christian, Marianne van Hage, Marco Waser (531937)   +54 more
core   +1 more source

Baseline data collections of lipopolysaccharide content in 414 herbal extracts and its role in innate immune activation

Scientific Reports
Some herbal extracts contain relatively high amounts of lipopolysaccharide (LPS). Because orally administered LPS activates innate immunity without inducing inflammation, it plays a role as an active ingredient in herbal extracts.
Vindy Tjendana Tjhin, Masataka Oda, Masashi Yamashita, Tomoko Iwaki, Yasuko Fujita, Koji Wakame, Hiroyuki Inagawa, Gen-Ichiro Soma   +7 more
doaj   +1 more source

Natural Killer Cells in Paediatric Soft Tissue Sarcomas: A Systematic Review

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Paediatric soft tissue sarcomas (pSTS) are a rare and heterogeneous group of malignant tumours arising in tissues of mesenchymal origin. The role of natural killer (NK) cells in pSTS remains poorly understood, with evidence fragmented across small preclinical studies and early‐phase clinical trials.
Raya Dean, Lara V. Graham, Christina Putnam, Rosa Gomes Alves Martins, Daniel T. Harding, Tim J. Underwood, Zoë S. Walters, Matthew D. Blunt   +7 more
wiley   +1 more source