Results 21 to 30 of about 9,268 (211)

Novel bimodal TRBD1-TRBD2 rearrangements with dual or absent D-region contribute to TRB V-(D)-J combinatorial diversity

Frontiers in Immunology, 2023
T-cell receptor (TR) diversity of the variable domains is generated by recombination of both the alpha (TRA) and beta (TRB) chains. The textbook process of TRB chain production starts with TRBD and TRBJ gene rearrangement, followed by the rearrangement ...
Anastasia O. Smirnova, Anastasia O. Smirnova, Anna M. Miroshnichenkova, Laima D. Belyaeva, Ilya V. Kelmanson, Yuri B. Lebedev, Yuri B. Lebedev, Ilgar Z. Mamedov, Dmitriy M. Chudakov, Dmitriy M. Chudakov, Dmitriy M. Chudakov, Dmitriy M. Chudakov, Alexander Y. Komkov, Alexander Y. Komkov, Alexander Y. Komkov   +14 more
doaj   +1 more source

Pharmacological validation of targets regulating CD14 during macrophage differentiation

EBioMedicine, 2020
The signalling receptor for LPS, CD14, is a key marker of, and facilitator for, pro-inflammatory macrophage function. Pro-inflammatory macrophage differentiation remains a process facilitating a broad array of disease pathologies, and has recently ...
Gisela Jimenez-Duran, Rosario Luque-Martin, Meghana Patel, Emma Koppe, Sharon Bernard, Catriona Sharp, Natalie Buchan, Ceara Rea, Menno P.J. de Winther, Nil Turan, Davina Angell, Christine A. Wells, Rick Cousins, Palwinder K. Mander, Seth L. Masters   +14 more
doaj   +1 more source

Adaptive immunity or evolutionary adaptation? Transgenerational immune systems at the crossroads

Biology & Philosophy, 2022
AbstractIn recent years, immune systems have sparked considerable interest within the philosophy of science. One issue that has received increased attention is whether other phyla besides vertebrates display an adaptive immune system. Particularly the discovery of CRISPR-Cas9-based systems has triggered a discussion about how to classify adaptive ...
openaire   +3 more sources

Adaptive Immunity in Hypertension [PDF]

Current Hypertension Reports, 2019
In recent years, a vast body of evidence has accumulated indicating the role of the immune system in the regulation of blood pressure and modulation of hypertensive pathology. Numerous cells of the immune system, both innate and adaptive immunity, have been indicated to play an important role in the development and maintenance of hypertension.
Tomasz P. Mikolajczyk, Tomasz J. Guzik
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Exploring the pre-immune landscape of antigen-specific T cells

Genome Medicine, 2018
Background Adaptive immune responses to newly encountered pathogens depend on the mobilization of antigen-specific clonotypes from a vastly diverse pool of naive T cells.
Mikhail V. Pogorelyy, Alla D. Fedorova, James E. McLaren, Kristin Ladell, Dmitri V. Bagaev, Alexey V. Eliseev, Artem I. Mikelov, Anna E. Koneva, Ivan V. Zvyagin, David A. Price, Dmitry M. Chudakov, Mikhail Shugay   +11 more
doaj   +1 more source

Adaptive Immunity and Inflammation [PDF]

International Journal of Inflammation, 2015
Inflammation is part of a complex biological response to injury as a result of different stimuli such as pathogens, damaged cells, or irritants. Local signals at the sites of inflammation mediate rapid cells mobilization and recruitment and dictate differentiation programs whereby these cells drive clearance of “inflammatory inducers” and promote ...
Brancaleone Vincenzo, Iqbal J. Asif, Paschalidis Nikolaos, Maione Francesco   +3 more
doaj   +3 more sources

The Adipocyte and Adaptive Immunity [PDF]

Frontiers in Immunology, 2020
Not only do Adipocytes have energy storage and endocrine functions, but they also play an immunological role. Adipocytes are involved in adaptive immunity to mediate the pathological processes of a variety of chronic inflammatory diseases and autoimmune syndromes.
Jianfeng Song, Jianfeng Song, Tuo Deng, Tuo Deng, Tuo Deng   +4 more
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Autophagy and adaptive immunity [PDF]

Immunology, 2010
SummaryAutophagy plays an important role in maintaining intracellular homeostasis by promoting the transit of cytoplasmic material, such as proteins, organelles and pathogens, for degradation within acidic organelles. Yet, in immune cells, autophagy pathways serve an additional role in facilitating intracellular surveillance for pathogens and changes ...
Victoria L, Crotzer, Janice S, Blum
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Adaptive Immunity to Fungi [PDF]

Cold Spring Harbor Perspectives in Medicine, 2014
Life-threatening fungal infections have risen sharply in recent years, owing to the advances and intensity of medical care that may blunt immunity in patients. This emerging crisis has created the growing need to clarify immune defense mechanisms against fungi with the ultimate goal of therapeutic intervention.
Akash, Verma, Marcel, Wüthrich, George, Deepe, Bruce, Klein   +3 more
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Innate and Adaptive Immunity in Immune Thrombocytopenia [PDF]

Seminars in Hematology, 2013
Immune thrombocytopenia (ITP) is an autoimmune disorder characterized by both accelerated clearance of autoantibody-sensitized platelets and suboptimal platelet production. A number of studies have provided evidence of disturbed innate and adaptive immune responses in patients with ITP.
Alan H, Lazarus, John W, Semple, Douglas B, Cines   +2 more
openaire   +2 more sources