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Adaptive Immunity in Hypertension [PDF]
Current Hypertension Reports, 2019 In recent years, a vast body of evidence has accumulated indicating the role of the immune system in the regulation of blood pressure and modulation of hypertensive pathology. Numerous cells of the immune system, both innate and adaptive immunity, have been indicated to play an important role in the development and maintenance of hypertension.
Mikolajczyk, Tomasz P., Guzik, Tomasz J.
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HBV-Specific Adaptive Immunity [PDF]
Viruses, 2009 The successful control of HBV infection requires an efficient expansion of distinct elements of the adaptive immune system (B cells, helper and cytotoxic T cells) that, due to the hepatotropic nature of HBV, need to operate in the liver parenchyma.
Adam J. Gehring +2 more
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Targeting innate immunity to downmodulate adaptive immunity and reverse type 1 diabetes [PDF]
ImmunoTargets and Therapy, 2017 Arata Itoh, William M Ridgway Division of Immunology, Allergy and Rheumatology, University of Cincinnati College of Medicine, Cincinnati, OH, USA Abstract: Type 1 diabetes (T1D) is characterized by specific destruction of pancreatic insulin-producing ...
Itoh A, Ridgway WM
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Targeting Host Innate and Adaptive Immunity to Achieve the Functional Cure of Chronic Hepatitis B [PDF]
, 2020 Despite the availability of an effective preventive vaccine for hepatitis B virus (HBV) for over 38 years, chronic HBV (CHB) infection remains a global health burden with around 257 million patients. The ideal treatment goal for CHB infection would be to
Michinori Kohara +4 more
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Adaptive Immunity to Fungi [PDF]
Annual Review of Immunology, 2012 Only a handful of the more than 100,000 fungal species on our planet cause disease in humans, yet the number of life-threatening fungal infections in patients has recently skyrocketed as a result of advances in medical care that often suppress immunity intensely.
Marcel, Wüthrich +2 more
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Frontiers in Immunology, 2023 T-cell receptor (TR) diversity of the variable domains is generated by recombination of both the alpha (TRA) and beta (TRB) chains. The textbook process of TRB chain production starts with TRBD and TRBJ gene rearrangement, followed by the rearrangement ...
Anastasia O. Smirnova +14 more
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Pharmacological validation of targets regulating CD14 during macrophage differentiation
EBioMedicine, 2020 The signalling receptor for LPS, CD14, is a key marker of, and facilitator for, pro-inflammatory macrophage function. Pro-inflammatory macrophage differentiation remains a process facilitating a broad array of disease pathologies, and has recently ...
Gisela Jimenez-Duran +14 more
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Adaptive immunity or evolutionary adaptation? Transgenerational immune systems at the crossroads
Biology & Philosophy, 2022 AbstractIn recent years, immune systems have sparked considerable interest within the philosophy of science. One issue that has received increased attention is whether other phyla besides vertebrates display an adaptive immune system. Particularly the discovery of CRISPR-Cas9-based systems has triggered a discussion about how to classify adaptive ...
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Exploring the pre-immune landscape of antigen-specific T cells
Genome Medicine, 2018 Background Adaptive immune responses to newly encountered pathogens depend on the mobilization of antigen-specific clonotypes from a vastly diverse pool of naive T cells.
Mikhail V. Pogorelyy +11 more
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Adaptive immunity in invertebrates: a straw house without a mechanistic foundation [PDF]
, 2007 Recently claims have been made for radical new insights in the field of invertebrate immunology that involve memory, specificity and/or maternal transfer of immunocompetence.
Smith, Valerie J., Hauton, Chris
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