Results 11 to 20 of about 505,030 (295)

The use of non-functional clonotypes as a natural calibrator for quantitative bias correction in adaptive immune receptor repertoire profiling

eLife, 2023
High-throughput sequencing of adaptive immune receptor repertoires is a valuable tool for receiving insights in adaptive immunity studies. Several powerful TCR/BCR repertoire reconstruction and analysis methods have been developed in the past decade ...
Anastasia O Smirnova, Anna M Miroshnichenkova, Yulia V Olshanskaya, Michael A Maschan, Yuri B Lebedev, Dmitriy M Chudakov, Ilgar Z Mamedov, Alexander Komkov   +7 more
doaj   +1 more source

Novel bimodal TRBD1-TRBD2 rearrangements with dual or absent D-region contribute to TRB V-(D)-J combinatorial diversity

Frontiers in Immunology, 2023
T-cell receptor (TR) diversity of the variable domains is generated by recombination of both the alpha (TRA) and beta (TRB) chains. The textbook process of TRB chain production starts with TRBD and TRBJ gene rearrangement, followed by the rearrangement ...
Anastasia O. Smirnova, Anastasia O. Smirnova, Anna M. Miroshnichenkova, Laima D. Belyaeva, Ilya V. Kelmanson, Yuri B. Lebedev, Yuri B. Lebedev, Ilgar Z. Mamedov, Dmitriy M. Chudakov, Dmitriy M. Chudakov, Dmitriy M. Chudakov, Dmitriy M. Chudakov, Alexander Y. Komkov, Alexander Y. Komkov, Alexander Y. Komkov   +14 more
doaj   +1 more source

Pharmacological validation of targets regulating CD14 during macrophage differentiation

EBioMedicine, 2020
The signalling receptor for LPS, CD14, is a key marker of, and facilitator for, pro-inflammatory macrophage function. Pro-inflammatory macrophage differentiation remains a process facilitating a broad array of disease pathologies, and has recently ...
Gisela Jimenez-Duran, Rosario Luque-Martin, Meghana Patel, Emma Koppe, Sharon Bernard, Catriona Sharp, Natalie Buchan, Ceara Rea, Menno P.J. de Winther, Nil Turan, Davina Angell, Christine A. Wells, Rick Cousins, Palwinder K. Mander, Seth L. Masters   +14 more
doaj   +1 more source

Adaptive immunity or evolutionary adaptation? Transgenerational immune systems at the crossroads

Biology & Philosophy, 2022
AbstractIn recent years, immune systems have sparked considerable interest within the philosophy of science. One issue that has received increased attention is whether other phyla besides vertebrates display an adaptive immune system. Particularly the discovery of CRISPR-Cas9-based systems has triggered a discussion about how to classify adaptive ...
openaire   +3 more sources

Exploring the pre-immune landscape of antigen-specific T cells

Genome Medicine, 2018
Background Adaptive immune responses to newly encountered pathogens depend on the mobilization of antigen-specific clonotypes from a vastly diverse pool of naive T cells.
Mikhail V. Pogorelyy, Alla D. Fedorova, James E. McLaren, Kristin Ladell, Dmitri V. Bagaev, Alexey V. Eliseev, Artem I. Mikelov, Anna E. Koneva, Ivan V. Zvyagin, David A. Price, Dmitry M. Chudakov, Mikhail Shugay   +11 more
doaj   +1 more source

'Towards a Conceptual Framework for Innate Immunity' [PDF]

, 2005
Innate immunity now occupies a central role in immunology. However, artificial immune system models have largely been inspired by adaptive not innate immunity.
Aickelin, Uwe, Twycross, Jamie
core   +3 more sources

TCR repertoire profiling revealed antigen-driven CD8+ T cell clonal groups shared in synovial fluid of patients with spondyloarthritis

Frontiers in Immunology, 2022
Spondyloarthritis (SpA) comprises a number of inflammatory rheumatic diseases with overlapping clinical manifestations. Strong association with several HLA-I alleles and T cell infiltration into an inflamed joint suggest involvement of T cells in SpA ...
Ekaterina A. Komech, Ekaterina A. Komech, Anastasia D. Koltakova, Anna A. Barinova, Anna A. Barinova, Anastasia A. Minervina, Maria A. Salnikova, Evgeniya I. Shmidt, Tatiana V. Korotaeva, Elena Y. Loginova, Shandor F. Erdes, Ekaterina A. Bogdanova, Ekaterina A. Bogdanova, Mikhail Shugay, Mikhail Shugay, Sergey Lukyanov, Sergey Lukyanov, Yury B. Lebedev, Yury B. Lebedev, Ivan V. Zvyagin, Ivan V. Zvyagin   +20 more
doaj   +1 more source

Intestinal macromolecular transport supporting adaptive immunity [PDF]

, 2019
The gastrointestinal tract performs opposing functions of nutrient absorption, barrier maintenance, and the delivery of luminal substances for the appropriate induction of tolerogenic or protective adaptive immunity.
Kulkarni, Devesha H, Newberry, Rodney D
core   +2 more sources

The Adipocyte and Adaptive Immunity [PDF]

Frontiers in Immunology, 2020
Not only do Adipocytes have energy storage and endocrine functions, but they also play an immunological role. Adipocytes are involved in adaptive immunity to mediate the pathological processes of a variety of chronic inflammatory diseases and autoimmune syndromes.
Jianfeng Song, Jianfeng Song, Tuo Deng, Tuo Deng, Tuo Deng   +4 more
openaire   +3 more sources

Influence of tumors on protective anti-tumor immunity and the effects of irradiation [PDF]

, 2013
Innate and adaptive immunity play important roles in the development and progression of cancer and it is becoming apparent that tumours can influence the induction of potentially protective responses in a number of ways.
Alan Graham Pockley, Gabriele eMulthoff, Gabriele eMulthoff, Gemma Ann Foulds, Gemma Ann Foulds, Jürgen eRadons, Mira eKreuzer   +6 more
core   +2 more sources