Results 11 to 20 of about 9,268 (211)
Adaptive Immunity in Pregnancy [PDF]
, 2021 One of the most remarkable features of reproductive biology is the fact that a healthy woman can successfully carry her genetically disparate conceptus to full term, without immune rejection. The juxtaposition of the placenta and decidua creates what is referred to as the ‘fetal-maternal interface’, where placental trophoblasts of fetal origin and ...
Piccinni MP, Saito S, Robertson SA
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eLife, 2023 Regulatory T cells (Tregs) are indispensable for maintaining self-tolerance by suppressing conventional T cells. On the other hand, Tregs promote tumor growth by inhibiting anticancer immunity.
Oksana Tsyklauri +13 more
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Frontiers in Immunology, 2022 Mature T cells are selected for recognizing self-antigens with low to intermediate affinity in the thymus. Recently, the relative differences in self-reactivity among individual T-cell clones were appreciated as important factors regulating their fate ...
Darina Paprckova +22 more
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Pinpointing the tumor-specific T cells via TCR clusters
eLife, 2022 Adoptive cell transfer (ACT) is a promising approach to cancer immunotherapy, but its efficiency fundamentally depends on the extent of tumor-specific T cell enrichment within the graft. This can be estimated via activation with identifiable neoantigens,
Mikhail M Goncharov +12 more
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Measuring Intratumoral Heterogeneity of Immune Repertoires
Frontiers in Oncology, 2020 There is considerable clinical and fundamental value in measuring the clonal heterogeneity of T and B cell expansions in tumors and tumor-associated lymphoid structures—along with the associated heterogeneity of the tumor neoantigen landscape—but such ...
Diana Vladimirovna Yuzhakova +30 more
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Adaptive immunity in the liver [PDF]
Cellular & Molecular Immunology, 2016 The anatomical architecture of the human liver and the diversity of its immune components endow the liver with its physiological function of immune competence. Adaptive immunity is a major arm of the immune system that is organized in a highly specialized and systematic manner, thus providing long-lasting protection with immunological memory.
Shuai, Zongwen +6 more
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Human rhinovirus promotes STING trafficking to replication organelles to promote viral replication
Nature Communications, 2022 Evidence exists that the typically antiviral signaling mediator STING is, counterintuitively, needed for optimal human rhinovirus infection. Here the authors confirm this finding and show how human rhinovirus can reduce stored Ca2+ levels to drive this ...
Martha Triantafilou +11 more
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Frontiers in Oncology, 2020 Substantial effort is being invested in the search for peripheral or intratumoral T cell receptor (TCR) repertoire features that could predict the response to immunotherapy.
Ekaterina A. Zhigalova +19 more
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eLife, 2023 High-throughput sequencing of adaptive immune receptor repertoires is a valuable tool for receiving insights in adaptive immunity studies. Several powerful TCR/BCR repertoire reconstruction and analysis methods have been developed in the past decade ...
Anastasia O Smirnova +7 more
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Adaptive Immunity to Fungi [PDF]
Annual Review of Immunology, 2012 Only a handful of the more than 100,000 fungal species on our planet cause disease in humans, yet the number of life-threatening fungal infections in patients has recently skyrocketed as a result of advances in medical care that often suppress immunity intensely.
Marcel, Wüthrich +2 more
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