Results 31 to 40 of about 1,761,502 (294)

Functionally specialized human CD4+ T-cell subsets express physicochemically distinct TCRs

eLife, 2020
The organizational integrity of the adaptive immune system is determined by functionally discrete subsets of CD4+ T cells, but it has remained unclear to what extent lineage choice is influenced by clonotypically expressed T-cell receptors (TCRs).
Sofya A Kasatskaya, Kristin Ladell, Evgeniy S Egorov, Kelly L Miners, Alexey N Davydov, Maria Metsger, Dmitry B Staroverov, Elena K Matveyshina, Irina A Shagina, Ilgar Z Mamedov, Mark Izraelson, Pavel V Shelyakin, Olga V Britanova, David A Price, Dmitriy M Chudakov   +14 more
doaj   +1 more source

Inactivated tick-borne encephalitis vaccine elicits several overlapping waves of T cell response

Frontiers in Immunology, 2022
The development and implementation of vaccines have been growing exponentially, remaining one of the major successes of healthcare over the last century.
Anastasiia L. Sycheva, Ekaterina A. Komech, Ekaterina A. Komech, Mikhail V. Pogorelyy, Anastasia A. Minervina, Shamil Z. Urazbakhtin, Maria A. Salnikova, Maria A. Salnikova, Mikhail F. Vorovitch, Mikhail F. Vorovitch, Eugene P. Kopantzev, Ivan V. Zvyagin, Ivan V. Zvyagin, Alexander Y. Komkov, Alexander Y. Komkov, Ilgar Z. Mamedov, Yuri B. Lebedev, Yuri B. Lebedev   +17 more
doaj   +1 more source

Intratumoral immunoglobulin isotypes predict survival in lung adenocarcinoma subtypes

Journal for ImmunoTherapy of Cancer, 2019
Background The role of tumor-infiltrating B-cells (TIBs) and intratumorally-produced antibodies in cancer-immunity interactions essentially remains terra incognita.
O. I. Isaeva, G. V. Sharonov, E. O. Serebrovskaya, M. A. Turchaninova, A. R. Zaretsky, M. Shugay, D. M. Chudakov   +6 more
doaj   +1 more source

Surface NKG2C Identifies Differentiated αβT-Cell Clones Expanded in Peripheral Blood

Frontiers in Immunology, 2021
T cells that express CD56 in peripheral blood of healthy humans represent a heterogeneous and poorly studied subset. In this work, we analyzed this subset for NKG2C expression. In both CD56+ and CD56− subsets most of the NKG2C+ T cells had a phenotype of
Elena I. Kovalenko, Ivan V. Zvyagin, Maria A. Streltsova, Artem I. Mikelov, Artem I. Mikelov, Sofya A. Erokhina, William G. Telford, Alexander M. Sapozhnikov, Yury B. Lebedev   +8 more
doaj   +1 more source

Let’s Tie the Knot: Marriage of Complement and Adaptive Immunity in Pathogen Evasion, for Better or Worse [PDF]

, 2017
The complement system is typically regarded as an effector arm of innate immunity, leading to recognition and killing of microbial invaders in body fluids.
Ronald D. Gorham, Suzan H. M. Rooijakkers, Bennett, Kaila M., Rooijakkers, Suzan H.M., Gorham, Ronald D., Kaila M. Bennett   +5 more
core   +2 more sources

Telomere and adaptive immunity [PDF]

Mechanisms of Ageing and Development, 2008
The adaptive immune response relies on the ability of lymphocytes to undergo periodic massive expansion. It is an enigma how lymphocytes are able to undergo this seemingly unlimited number of cell divisions. Telomeres and telomerase play a critical role in regulation of the replicative lifespan of cells, providing a potential mechanism which ...
openaire   +2 more sources

Innate and Adaptive Immunity in Immune Thrombocytopenia [PDF]

Seminars in Hematology, 2013
Immune thrombocytopenia (ITP) is an autoimmune disorder characterized by both accelerated clearance of autoantibody-sensitized platelets and suboptimal platelet production. A number of studies have provided evidence of disturbed innate and adaptive immune responses in patients with ITP.
Alan H, Lazarus, John W, Semple, Douglas B, Cines   +2 more
openaire   +2 more sources

CXCL12 Mediates Aberrant Costimulation of B Lymphocytes in Warts, Hypogammaglobulinemia, Infections, Myelokathexis Immunodeficiency

Frontiers in Immunology, 2017
The Warts, Hypogammaglobulinemia, Infections, Myelokathexis (WHIM) syndrome is an immunodeficiency caused by mutations in chemokine receptor CXCR4. WHIM patient adaptive immunity defects remain largely unexplained.
Giuliana Roselli, Elisa Martini, Vassilios Lougaris, Raffaele Badolato, Antonella Viola, Antonella Viola, Marinos Kallikourdis, Marinos Kallikourdis   +7 more
doaj   +1 more source

Adaptation and Immunity

PLoS Biology, 2004
The ongoing battle between hosts and pathogens has long been of interest to evolutionary biologists.
openaire   +4 more sources

Cellular immunity of naïve and BCG vaccinated neonates [PDF]

, 2010
Includes abstract.Includes bibliographical references (leaves 153-187).Despite more than 95% vaccination coverage with Mycobacterium bovis Bacille Calmette-Guérin (BCG), tuberculosis (TB) remains epidemic in South Africa.
Watkins, Marcia Linda Vivienne
core   +1 more source