Results 31 to 40 of about 312,631 (303)

Functionally specialized human CD4+ T-cell subsets express physicochemically distinct TCRs

eLife, 2020
The organizational integrity of the adaptive immune system is determined by functionally discrete subsets of CD4+ T cells, but it has remained unclear to what extent lineage choice is influenced by clonotypically expressed T-cell receptors (TCRs).
Sofya A Kasatskaya, Kristin Ladell, Evgeniy S Egorov, Kelly L Miners, Alexey N Davydov, Maria Metsger, Dmitry B Staroverov, Elena K Matveyshina, Irina A Shagina, Ilgar Z Mamedov, Mark Izraelson, Pavel V Shelyakin, Olga V Britanova, David A Price, Dmitriy M Chudakov   +14 more
doaj   +1 more source

Inactivated tick-borne encephalitis vaccine elicits several overlapping waves of T cell response

Frontiers in Immunology, 2022
The development and implementation of vaccines have been growing exponentially, remaining one of the major successes of healthcare over the last century.
Anastasiia L. Sycheva, Ekaterina A. Komech, Ekaterina A. Komech, Mikhail V. Pogorelyy, Anastasia A. Minervina, Shamil Z. Urazbakhtin, Maria A. Salnikova, Maria A. Salnikova, Mikhail F. Vorovitch, Mikhail F. Vorovitch, Eugene P. Kopantzev, Ivan V. Zvyagin, Ivan V. Zvyagin, Alexander Y. Komkov, Alexander Y. Komkov, Ilgar Z. Mamedov, Yuri B. Lebedev, Yuri B. Lebedev   +17 more
doaj   +1 more source

Adaptive Immunity to Fungi [PDF]

Cold Spring Harbor Perspectives in Medicine, 2014
Life-threatening fungal infections have risen sharply in recent years, owing to the advances and intensity of medical care that may blunt immunity in patients. This emerging crisis has created the growing need to clarify immune defense mechanisms against fungi with the ultimate goal of therapeutic intervention.
Akash, Verma, Marcel, Wüthrich, George, Deepe, Bruce, Klein   +3 more
openaire   +2 more sources

Let’s Tie the Knot: Marriage of Complement and Adaptive Immunity in Pathogen Evasion, for Better or Worse [PDF]

, 2017
The complement system is typically regarded as an effector arm of innate immunity, leading to recognition and killing of microbial invaders in body fluids.
Ronald D. Gorham, Suzan H. M. Rooijakkers, Bennett, Kaila M., Rooijakkers, Suzan H.M., Gorham, Ronald D., Kaila M. Bennett   +5 more
core   +1 more source

Bacterial Modulation of Fc Effector Functions [PDF]

, 2013
Immunoglobulins (Igs, antibodies) are key players in adaptive immunity, and pathways mediated through the effector Fc portion of Ig are instrumental in controlling bacterial infections.
Collin, Mattias,, Kilian, Mogens,, Lund University.   +2 more
core   +1 more source

Surface NKG2C Identifies Differentiated αβT-Cell Clones Expanded in Peripheral Blood

Frontiers in Immunology, 2021
T cells that express CD56 in peripheral blood of healthy humans represent a heterogeneous and poorly studied subset. In this work, we analyzed this subset for NKG2C expression. In both CD56+ and CD56− subsets most of the NKG2C+ T cells had a phenotype of
Elena I. Kovalenko, Ivan V. Zvyagin, Maria A. Streltsova, Artem I. Mikelov, Artem I. Mikelov, Sofya A. Erokhina, William G. Telford, Alexander M. Sapozhnikov, Yury B. Lebedev   +8 more
doaj   +1 more source

Trained Immunity as an Adaptive Branch of Innate Immunity [PDF]

, 2021
The concept of trained immunity has become one of the most interesting and potentially commercially and clinically relevant ideas of current immunology. Trained immunity is realized by the epigenetic reprogramming of non-immunocompetent cells, primarily ...
Vaclav Vetvicka, Petr Sima, Luca Vannucci   +2 more
core   +1 more source

Innate and Adaptive Immunity in Immune Thrombocytopenia [PDF]

Seminars in Hematology, 2013
Immune thrombocytopenia (ITP) is an autoimmune disorder characterized by both accelerated clearance of autoantibody-sensitized platelets and suboptimal platelet production. A number of studies have provided evidence of disturbed innate and adaptive immune responses in patients with ITP.
Alan H, Lazarus, John W, Semple, Douglas B, Cines   +2 more
openaire   +2 more sources

Host-microbiota interactions and adaptive immunity. [PDF]

, 2017
All mucosal surfaces are colonized with a vast number of microbes, which are essential for stimulating and regulating the immune system. While intrinsic and innate mechanisms exist to promote a strong barrier between the microbiota and the host to ensure
Kathy D. McCoy, Ronchi, Francesca, Francesca Ronchi, McCoy, Kathy D, Geuking, Markus B, Markus B. Geuking   +5 more
core   +1 more source

Influence of tumours on protective anti-tumour immunity and the effects of irradiation [PDF]

, 2013
Innate and adaptive immunity play important roles in the development and progression of cancer and it is becoming apparent that tumours can influence the induction of potentially protective responses in a number of ways.
Alan G. Pockley, Foulds, GA, Gemma A. Foulds, Alan Graham Pockley, Kreuzer, M, Gemma Ann Foulds, Radons, J., Gabriele eMulthoff, Radons, J, Pockley, AG, Kreuzer, M., Foulds, G.A., Jürgen eRadons, Jürgen Radons, Multhoff, G., Gabriele Multhoff, Mira eKreuzer, Pockley, A.G., Multhoff, G, Mira Kreuzer   +19 more
core   +1 more source