T-Cell Senescence in Human Metabolic Diseases [PDF]
Diabetes & Metabolism JournalImmunosenescence denotes a state of dysregulated immune cell function characterized by a confluence of factors, including arrested cell cycle, telomere shortening, markers of cellular stress, mitochondrial dysfunction, loss of proteostasis, epigenetic ...
Ha Thi Nga +2 more
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PI3K in T Cell Adhesion and Trafficking
Frontiers in Immunology, 2021 PI3K signalling is required for activation, differentiation, and trafficking of T cells. PI3Kδ, the dominant PI3K isoform in T cells, has been extensively characterised using PI3Kδ mutant mouse models and PI3K inhibitors. Furthermore, characterisation of
Kristoffer H. Johansen +5 more
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The immune system as drug target [PDF]
, 2013 The immune system is perhaps the largest yet most diffuse and distributed somatic system in vertebrates. It plays vital roles in fighting infection and in the homeostatic control of chronic disease.
Flower, Darren R.
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Structural mechanism of tapasin-mediated MHC-I peptide loading in antigen presentation
Nature Communications, 2022 The catalytic chaperone tapasin assists peptide loading onto MHC-I molecules for antigen presentation and immune recognition. Here, the authors present crystal structures that provide insights into the molecular mechanism of tapasin-mediated peptide ...
Jiansheng Jiang +11 more
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MicroRNA in the immune system, microRNA as an immune system
Immunology, 2009 SummaryThe advent of microRNA has potentially uncovered a new level of complexity to be considered for every biological process. Through the modulation of transcription and translation, microRNA alter the basal state of cells and the outcome of stimulatory events. The exact effect of the microRNA network and individual microRNA on cellular processes is
Lu, Li-Fan, Liston, Adrian
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Muscle Loss Driven by Extracellular Signal-Regulated Kinase Suppression via β-Adrenergic Activation in High-Normal Catecholamine Status [PDF]
Endocrinology and MetabolismBackground Catecholamines play a crucial role in muscle biogenesis, but their persistent elevation is linked to muscle wasting, which is poorly understood.
Jieun Lee +12 more
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Differences in Type 2 Fiber Composition in the Vastus Lateralis and Gluteus Maximus of Patients with Hip Fractures [PDF]
Endocrinology and MetabolismBackground Aging leads to sarcopenia, which is characterized by reduced muscle mass and strength. Many factors, including altered muscle protein turnover, diminished neuromuscular function, hormonal changes, systemic inflammation, and the structure and ...
Jingwen Tian +11 more
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The Immune System of Marine Organisms as Source for Drugs against Infectious Diseases [PDF]
, 2022 The high proliferation of microorganisms in aquatic environments has allowed their coevolution for billions of years with other living beings that also inhabit these niches.
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Emergent networks in immune system shape space [PDF]
, 2005 The development of a computational model is reported which facilitates the study of emergent principles of human immune system effector T cell clonotype repertoire and its distribution and differentiation.
Burns, John
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Normalizing and denoising protein expression data from droplet-based single cell profiling
Nature Communications, 2022 Current single cell protein expression profiling approaches come with substantial measurement noise. Here the authors discover the sources of this noise and develop a denoising algorithm that improves data quality and downstream applications.
Matthew P. Mulè +2 more
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