A role for kinesin heavy chain in controlling vesicle transport into dendrites in Drosophila. [PDF]
, 2011 The unique architecture of neurons requires the establishment and maintenance of polarity, which relies in part on microtubule-based transport to deliver essential cargo into dendrites.
Goldstein, Lawrence SB +3 more
core +2 more sources
Co-occurrence of TDP-43 mislocalization with reduced activity of an RNA editing enzyme, ADAR2, in aged mouse motor neurons. [PDF]
PLoS ONE, 2012 TDP-43 pathology in spinal motor neurons is a neuropathological hallmark of sporadic amyotrophic lateral sclerosis (ALS) and has recently been shown to be closely associated with the downregulation of an RNA editing enzyme called adenosine deaminase ...
Takuto Hideyama +4 more
doaj +1 more source
Neuron-Specific HuR-Deficient Mice Spontaneously Develop Motor Neuron Disease [PDF]
, 2018 Human Ag R (HuR) is an RNA binding protein in the ELAVL protein family. To study the neuron-specific function of HuR, we generated inducible, neuron-specific HuR-deficient mice of both sexes.
Bai, Ying +10 more
core +1 more source
Visuomotor Transformation in the Fly Gaze Stabilization System [PDF]
, 2008 For sensory signals to control an animal's behavior, they must first be transformed into a format appropriate for use by its motor systems. This fundamental problem is faced by all animals, including humans.
Holger G Krapp +2 more
core +9 more sources
Functional Diversification of Motor Neuron-specific Isl1 Enhancers during Evolution.
PLoS Genetics, 2015 Functional diversification of motor neurons has occurred in order to selectively control the movements of different body parts including head, trunk and limbs.
Namhee Kim +3 more
doaj +1 more source
Recognizing Speech in a Novel Accent: The Motor Theory of Speech Perception Reframed [PDF]
, 2013 The motor theory of speech perception holds that we perceive the speech of another in terms of a motor representation of that speech. However, when we have learned to recognize a foreign accent, it seems plausible that recognition of a word rarely ...
A Basirat +69 more
core +4 more sources
Stem Cells International, 2016 The Charcot-Marie-Tooth disease 2F (CMT2F) and distal hereditary motor neuropathy 2B (dHMN2B) are caused by autosomal dominantly inherited mutations of the heat shock 27 kDa protein 1 (HSPB1) gene and there are no specific therapies available yet.
Ji-Yon Kim +11 more
doaj +1 more source
Nature Communications, 2023 Insults to the developing cerebellum can cause motor, language, and social deficits. Here, we investigate whether developmental insults to different cerebellar neurons constrain the ability to acquire cerebellar-dependent behaviors. We perturb cerebellar
Meike E. van der Heijden +6 more
doaj +1 more source
Identification of early gene expression changes in primary cultured neurons treated with topoisomerase I poisons. [PDF]
, 2016 Topoisomerase 1 (TOP1) poisons like camptothecin (CPT) are currently used in cancer chemotherapy but these compounds can have damaging, off-target effects on neurons leading to cognitive, sensory and motor deficits.
Butchbach, Matthew E.R. +7 more
core +2 more sources
Direct conversion of human pluripotent stem cells into cranial motor neurons using a piggyBac vector [PDF]
, 2018 Human pluripotent stem cells (PSCs) are widely used for in vitro disease modeling. One of the challenges in the field is represented by the ability of converting human PSCs into specific disease-relevant cell types.
De Santis, Riccardo +5 more
core +2 more sources