Results 41 to 50 of about 30,311 (209)

Circadian Clock Control of Translation Initiation Factor eIF2α Activity Requires eIF2γ-Dependent Recruitment of Rhythmic PPP-1 Phosphatase in Neurospora crassa

mBio, 2021
Circadian clock control of mRNA translation contributes to the daily cycling of a significant proportion of the cellular protein synthesis, but how this is accomplished is not understood.
Zhaolan Ding, Teresa M. Lamb, Ahmad Boukhris, Rachel Porter, Deborah Bell-Pedersen   +4 more
doaj   +1 more source

Ion Chemistry in Dielectric Barrier Discharge Ionization: Recent Advances in Direct Gas Phase Analyses

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Dielectric barrier discharge ionization (DBDI) sources, employing low‐temperature plasma, have emerged as sensitive and efficient ionization tools with various atmospheric pressure ionization processes. In this review, we summarize a historical overview of the development of DBDI, highlighting key principles of gas‐phase ion chemistry and the ...
Kseniya Dryahina, Miroslav Polášek, Juraj Jašík, Kristýna Sovová, Patrik Španěl   +4 more
wiley   +1 more source

Histone H3 lysine 4 methyltransferase is required for facultative heterochromatin at specific loci

BMC Genomics, 2019
Background Histone H3 lysine 4 tri-methylation (H3K4me3) and histone H3 lysine 9 tri-methylation (H3K9me3) are widely perceived to be opposing and often mutually exclusive chromatin modifications.
Qiaoqiao Zhu, Mukund Ramakrishnan, Jinhee Park, William J. Belden   +3 more
doaj   +1 more source

Conserved function of a RasGEF‐mediated pathway in the metabolic compensation of the circadian clock

The FEBS Journal, EarlyView.
Metabolic compensation of the circadian clock is essential for stabilizing the period of endogenous timekeeping in environments with significant nutrient fluctuations. In this study, we demonstrate that RasGEF (SOS1)‐mediated signaling, which is influenced by metabolic conditions, supports the robust function of the circadian clock under low glucose ...
Orsolya Sárkány, Anita Szőke, Aladár Pettkó‐Szandtner, Eszter Éva Kálmán, Michael Brunner, Norbert Gyöngyösi, Krisztina Káldi   +6 more
wiley   +1 more source

The Neurospora photoreceptor VIVID exerts negative and positive control on light sensing to achieve adaptation

Molecular Systems Biology, 2013
The light response in Neurospora is mediated by the photoreceptor and circadian transcription factor White Collar Complex (WCC). The expression rate of the WCC target genes adapts in daylight and remains refractory to moonlight, despite the extraordinary
Elan Gin, Axel C R Diernfellner, Michael Brunner, Thomas Höfer   +3 more
doaj   +1 more source

In vivo and in silico models of Drosophila for Parkinson's disease

The FEBS Journal, EarlyView.
In vivo and in silico models of Drosophila offer valuable advantages in the generation, analysis, and interpretation of complex biological data, thereby significantly advancing our understanding of Parkinson's disease. Molecular‐level measurements and phenotypic data from Drosophila are extensively utilised in metabolic network modeling and artificial ...
Müberra Fatma Cesur, Rachel Strazdins, Souvarish Sarkar, Tunahan Çakır   +3 more
wiley   +1 more source

Aspects of the Neurospora crassa Sulfur Starvation Response Are Revealed by Transcriptional Profiling and DNA Affinity Purification Sequencing

mSphere, 2021
Identification of nutrients present in the environment is a challenge common to all organisms. Sulfur is an important nutrient source found in proteins, lipids, and electron carriers that are required for the survival of filamentous fungi such as ...
Lori B. Huberman, Vincent W. Wu, Juna Lee, Chris Daum, Ronan C. O’Malley, N. Louise Glass   +5 more
doaj   +1 more source

Advancing forest pathology: the need for community‐driven molecular experimental model systems

New Phytologist, EarlyView.
Summary Forests world‐wide are under escalating threat from emerging and invasive fungal and oomycete pathogens, driven by globalization and shifting climate dynamics. Effective strategies to manage the current scale and rate of changes in forest health remain hindered by our limited ability to study the underlying mechanisms of pathogen–host and ...
Anne G. Oostlander, André Fleißner, Bernard Slippers   +2 more
wiley   +1 more source

ENKAPSULASI DAN STABILITAS PIGMEN KAROTENOID DARI Neurospora intermedia N-1 (Encapsulation and the Stability of Carotenoids from Neurospora intermedia N-1)

Jurnal Manusia dan Lingkungan, 2011
ABSTRAK Neurospora sp merupakan spesies fungi yang dilaporkan menghasilkan pigmen karotenoid, yaitu metabolit sekunder yang termasuk kelompok pigmen yang berwarna kuning, jingga atau merah jingga.
T. Gusdinar, Marlia Singgih, Sri Priatni, AE. Sukmawati, Tri Suciati   +4 more
doaj   +1 more source

Aminoisothiazolamides, a new class of potent inhibitors of lysyl‐tRNA synthetase

Pest Management Science, Volume 81, Issue 7, Page 3956-3983, July 2025.
The present work covers a series of novel herbicidal lead structures that possess an aminoisothiazolamide scaffold as a structural key feature. Lysyl‐tRNA synthetase 1 (KRS1) was identified as the biochemical mode‐of‐action. Based on optimized and tailored synthetic approaches, a broader SAR study was carried out delivering some lead structures that ...
David Bernier, David M Barber, Guido Bojack, Birgit Bollenbach‐Wahl, Luke Churchman, Uwe Döller, Tyler Fahrenhorst‐Jones, Jörg Freigang, Elmar Gatzweiler, Claudia Hartfiel, Caroline Hilmi, Yoann Huet, Bernd Laber, Gudrun Lange, Stephanie Lee, Virginie Lempereur, Marc Mosrin, Thomas Müller, China M Payne, Olaf Peters, Luka Posa, Shaun Rees, Anna M Reingruber, Jullien Rey, Jörg Tiebes, Karen Tilmant, Jens Frackenpohl   +26 more
wiley   +1 more source