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Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects nearly one‐third of the global population and poses a significant risk of progression to cirrhosis or liver cancer. Here, we discuss the roles of hepatic dendritic cell subtypes in MASLD, highlighting their distinct contributions to disease initiation and progression, and their ...
Camilla Klaimi+3 more
wiley +1 more source
From bioavailability science to regulation of organic chemicals [PDF]
The bioavailability of organic chemicals in soil and sediment is an important area of scientific investigation for environmental scientists, although this area of study remains only partially recognized by regulators and industries working in the ...
Bram Versonnen+15 more
core +1 more source
Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source
Food Safety Debate and Development of Standards/Regulations for Organic Farming and Organic Food [PDF]
There is an on-going debate, in which way Organic Food production systems do contribute to food safety. Only few comparative studies do exist. However Organic Farming developed a system approach which is mainly focussing on the process of production ...
Schmid, Otto
core
Toll‐like receptors (TLRs) are important in the innate immune system. This study explores the zinc‐binding ability of the TLR2 TIR domain (TLR2TIR). We found that TLR2TIR binds zinc with nanomolar affinity through its cysteine residues. Two of them, C673 and C713, are vital for receptor activation, indicating that zinc may play a role in initiating ...
Vladislav A. Lushpa+8 more
wiley +1 more source
The power of microRNA regulation—insights into immunity and metabolism
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto+2 more
wiley +1 more source
Diffusion of volatile organic chemicals in porous media. 2. alcohol/templated porous carbon systems [PDF]
The aim of the present report was to measure the diffusion coefficients, modes of transport, and activation energies of some alcohols into templated porous carbons.
Sakintuna, Billur+2 more
core +1 more source
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley +1 more source
Metal Distribution and Short-Time Variability in Recent Sediments from the Ganges River towards the Bay of Bengal (India) [PDF]
The Ganges River receives inputs from highly populated cities of India (New Delhi, Calcutta, among others) and a strong influence of anthropogenic activities until reaching the Bay of Bengal.
Hakanson+4 more
core +2 more sources
Biomass - Renewable Feedstock for Organic Chemicals ( [PDF]
Limited resources compel us to turn to renewable sources, new and old, that are capable of supporting sustainable development of the human society, and satisfying the demand in energy and materials.
V. P. Kukhar
doaj