Results 41 to 50 of about 36,943 (245)

Formation of 2-nitrophenol from salicylaldehyde as a suitable test for low peroxynitrite fluxes

Redox Biology, 2016
There has been some dispute regarding reaction products formed at physiological peroxynitrite fluxes in the nanomolar range with phenolic molecules, when used to predict the behavior of protein-bound aromatic amino acids like tyrosine.
Yuliya Mikhed, Kai Bruns, Stefan Schildknecht, Michael Jörg, Mobin Dib, Matthias Oelze, Karl J. Lackner, Thomas Münzel, Volker Ullrich, Andreas Daiber   +9 more
doaj   +1 more source

Advances in Nano‐Immunomodulatory Systems for the Treatment of Acute Kidney Injury

Advanced Science, EarlyView.
Based on the biodegradability and the immunological reactiveness, IMNs can be broadly classified into four categories. The first category includes types of biologically derived materials that cause immunomodulatory action and biodegradability like nanoparticles of cell membranes, extracellular vesicles, and exosomes.
Chenli Zhang, Zeli Xiang, Pengfei Yang, Ling Zhang, Jun Deng, Xiaohui Liao   +5 more
wiley   +1 more source

Simultaneous Monitoring of Tyrosinase and ATP in Thick Brain Tissues Using a Single Two‐Photon Fluorescent Probe

Advanced Science, EarlyView.
A single dual‐emission two‐photon fluorescent probe is designed for simultaneously tracking tyrosinase (TYR) and adenosine triphosphate (ATP). With the help of this probe, the intricate correlation and regulatory mechanism between TYR and ATP during oxidative stress is uncovered.
Hong Huang, Huiru Li, Yong Zhang, Xuhan Xia, Ningwen Zhang, Haixin Fan, Longhua Guo, Yongyong Cao, Hu Pan, Ruijie Deng, Yangang Wang, Rodrigo Ledesma‐Amaro, Jianguo Xu   +12 more
wiley   +1 more source

Serum E3 SUMO-protein ligase NSE2 level and peroxynitrite related to oxidative stress in nephrolithiasis patients

Asian Pacific Journal of Tropical Biomedicine, 2017
Objective: To prove probable relations between serum E3 SUMO-protein ligase NSE2 (NSMCE2) concentration, peroxynitrite related to oxidative stress in nephrolithiasis patients. Methods: A total of 60 patients with nephrolithiasis and 50 healthy volunteers
Atheer Awad Mehde, Faridah Yusof, Wesen Adel Mehdi, Raha Ahmed Raus, Layla Othman Farhan, Jwan Abdulmohsin Zainulabdeen, Zaima Azira Zainal Abidin, Hamid Ghazali, Azlina Abd Rahman   +8 more
doaj   +1 more source

IR783‐Stabilized Nanodrugs Enhance Anticancer Immune Response by Synergizing Oxidation Therapy and Epigenetic Modulation

Advanced Science, EarlyView.
IR783‐stabilized nanodrugs composed of NIR dye IR783, ROS inducer β‐lapachone, and epigenetic modulator CUDC101 are designed for breast cancer immunotherapy. The nanodrugs can not only promote cancer cell apoptosis through HDAC inhibition‐enhanced oxidation therapy but also reshape the immunosuppressive microenvironment, which provides a novel strategy
Jinzhao Liu, Meicen Wu, Qingyang Lyu, Chang Yang, Ni Fan, Kang Chen, Weiping Wang   +6 more
wiley   +1 more source

Ultrasound‐Responsive 4D Bioscaffold for Synergistic Sonopiezoelectric‐Gaseous Osteosarcoma Therapy and Enhanced Bone Regeneration

Advanced Science, EarlyView.
An acoustic‐responsive therapeutic platform for synergistic sonopiezoelectric‐gaseous osteosarcoma therapy and bone regeneration is fabricated through the joint loading of few‐layer black phosphorus nanosheets and S‐Nitroso‐L‐glutathione onto the 3D‐printed bioactive glass scaffolds.
Haoyu Fang, Daoyu Zhu, Yixuan Chen, Changqing Zhang, Gan Li, Qihang Fang, Meiqi Chang, Yu Chen, Youshui Gao   +8 more
wiley   +1 more source

Endogenous Near‐Infrared Chemiluminescence: Imaging‐Guided Non‐Invasive Thrombolysis and Anti‐Inflammation Based on a Heteronuclear Transition Metal Complex

Advanced Science, EarlyView.
Cu2Ir NPs based on a Cu‐porphyrin core and cyclometalated Ir(III) substituents achieve combined endogenous peroxynitrite‐triggered NIR chemiluminescence imaging, PTT and PDT for successfully achieving safe thrombolysis, antioxidant and anti‐inflammatory multifunctionality in one single molecule.
Ziwei Wang, Bo Zhu, Wenxin Nie, Liping Zhang, Nan Xiao, Qiaohua Zhang, Zihan Wu, Chunguang Shi, Weijin Zhu, Qianwen Liu, Dongxia Zhu, Martin R. Bryce, Lijie Ren, Ben Zhong Tang   +13 more
wiley   +1 more source

An Efficient Heat and Peroxynitrite Generating Nanoplatform for Multimodal Imaging‐guided Precision Tumor Phototherapy

Aggregate, EarlyView.
Reported herein is the rational‐designed aggregation‐induced emission molecule (BPT), its nanoparticles (BPT NPs), and further processed heat and peroxynitrite generating nanoplatform for precision multimodal imaging‐guided tumor phototherapy. This nanoplatform showed near‐infrared II fluorescence, photothermal, and photoacoustic imaging capabilities ...
Ziyi Xu, Mingkun Lv, Jingkai Yang, Tingting Li, Jiahui Lv, Jiaxin Li, Hongjun Xiao, Yicheng Yang, Siyu Zhou, Xuan Tan, Li Cheng, Heng Guo, Lei Xi, Pan‐Lin Shao, Bo Zhang   +14 more
wiley   +1 more source

Human nitrobindin: the first example of an all‐β‐barrel ferric heme‐protein that catalyzes peroxynitrite detoxification

FEBS Open Bio, 2018
Nitrobindins (Nbs), constituting a heme‐protein family spanning from bacteria to Homo sapiens, display an all‐β‐barrel structural organization. Human Nb has been described as a domain of the nuclear protein named THAP4, whose physiological function is ...
Giovanna De Simone, Alessandra di Masi, Fabio Polticelli, Paolo Ascenzi   +3 more
doaj   +1 more source

S-Nitrosoglutathione reduces oxidative injury and promotes mechanisms of neurorepair following traumatic brain injury in rats

Journal of Neuroinflammation, 2011
Background Traumatic brain injury (TBI) induces primary and secondary damage in both the endothelium and the brain parenchyma, collectively termed the neurovascular unit.
Gilg Anne G, Im Yeong-Bin, Shunmugavel Anandakumar, Dhammu Tajinder S, Sakakima Harutoshi, Khan Mushfiquddin, Singh Avtar K, Singh Inderjit   +7 more
doaj   +1 more source