Results 41 to 50 of about 54,063 (260)

Excited‐State Basicity Diverts the Site‐Selectivity of Aromatic Deuteration: Application to the Late‐Stage Labelling of Pharmaceuticals.

Angewandte Chemie International Edition, Accepted Article.
Isotope labelling, particularly with deuterium (2H), plays a critical role in drug discovery due to its ease of incorporation and its potential to switch unwanted metabolic transformations. Deuterium incorporation can enhance drug stability, affect pharmacokinetics, and alter metabolism pathways.
Eva Rivera-Chao, Javier Corpas, Giovanni Lonardi, Volker Derdau, Alessandro Ruffoni, Daniele Leonori   +5 more
wiley   +1 more source

A descriptive analysis of pharmacological management of aggression and/or agitation in patients with traumatic brain injury in a Southwest Virginia inpatient population

Journal of Clinical Pharmacy and Therapeutics, Volume 47, Issue 12, Page 2083-2090, December 2022., 2022
Traumatic brain injury (TBI) is a major cause of disability, and it has been associated with agitation and aggression. In this study, we examined the psycho‐pharmacological agents that were administered to patients with agitation and/or aggression in the context of TBI in inpatient facilities of a private, non‐profit health care system in Southwest ...
Elham Rahmani, Tricia Lemelle, Hunter Sharp, Ehsan Smarbafzadeh, Anita Kablinger   +4 more
wiley   +1 more source

Solanidine‐derived CYP2D6 phenotyping elucidates phenoconversion in multimedicated geriatric patients

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims Phenoconversion, a genotype‐phenotype mismatch, challenges a successful implementation of personalized medicine. The aim of this study was to detect and determine phenoconversion using the solanidine metabolites 3,4‐seco‐solanidine‐3,4‐dioic acid (SSDA) and 4‐OH‐solanidine as diet‐derived cytochrome P450 2D6 (CYP2D6) biomarkers in a ...
Jens Andreas Sarömba, Julian Peter Müller, Jolanta Tupiec, Anjali Roeth, Berkan Kurt, Florian Kahles, Thea Laurentius, Cornelius Bollheimer, Julia C. Stingl, Katja S. Just   +9 more
wiley   +1 more source

Level of therapeutic innovation from the registration studies of the new drugs for the prophylaxis of migraine

Journal of Clinical Pharmacy and Therapeutics, Volume 47, Issue 12, Page 2130-2139, December 2022., 2022
The new monoclonal antibodies of the class of CGRP targeting therapies have been authorized with efficacy data only against placebo. They do not offer additional clinical benefits compared to available therapies for the prevention of migraine attacks, with the exception of a lower frequency of administration.
Domenico Motola, Greta Santi Laurini, Giulia Bonaldo, Nicola Montanaro   +3 more
wiley   +1 more source

Involution of a Large Parotid Hemangioma with Oral Propranolol: An Illustrative Report and Review of the Literature

Case Reports in Pediatrics, 2012
Propranolol has emerged as a new treatment option for infantile hemangiomas. We describe a 20-month-old boy with a large right parotid hemangioma diagnosed at the age of 37 days.
Elpis Mantadakis, Emmanouela Tsouvala, Savas Deftereos, Vassilios Danielides, Athanassios Chatzimichael   +4 more
doaj   +1 more source

Propranolol: A 50-year historical perspective

Annals of Indian Academy of Neurology, 2019
Propranolol is a beta-adrenergic receptor antagonist that was developed by the British scientist Sir James Black primarily for the treatment of angina pectoris, more than 50 years ago.
A V Srinivasan
doaj   +1 more source

Effects of oral propranolol on the resistive and pulsatility indices of major abdominal vasculatures in domestic short‐haired cats

Veterinary Medicine and Science, 2023
Background No study has been performed regarding the effects of oral administration of propranolol on pulse‐wave spectral Doppler indices of major abdominal vessels in healthy adult cats. Objective The objective of this study was to assess the pulse‐wave
Shima Amini Masouleh, Mohammad Nasrollahzadeh Masouleh, Bita Vazir, Saied Bokaie   +3 more
doaj   +1 more source

Assessing the environmental impact of medicines in Italy using data from the Italian Medicines Agency

British Journal of Clinical Pharmacology, EarlyView.
Aim This study builds on the environmental risk analysis presented in the 2022 National Report on Medicines Use in Italy by the Italian Medicines Agency and aims to assess the environmental risk posed by medicines in Italy and its regions. Methods The analysis selected 90 medicines based on three criteria: high utilization, low predicted no effect ...
Valentina Giunchi, Michele Fusaroli, Agnese Cangini, Filomena Fortinguerra, Simona Zito, Andrea Pierantozzi, Carlotta Lunghi, Elisabetta Poluzzi, Francesco Trotta   +8 more
wiley   +1 more source

Unrecognized liver cirrhosis is common and associated with worse survival in hepatocellular carcinoma: A nationwide cohort study of 3473 patients

Journal of Internal Medicine, Volume 293, Issue 2, Page 184-199, February 2023., 2023
Abstract Background Data on unrecognized liver cirrhosis in patients with hepatocellular carcinoma (HCC) are derived mainly from cohorts with a risk of selection bias. Objectives In a population‐based cohort study we aimed to determine the proportion, characteristics, and prognosis of HCC in patients with unrecognized cirrhosis.
Juan Vaz, Ulf Strömberg, Patrik Midlöv, Berne Eriksson, David Buchebner, Hannes Hagström   +5 more
wiley   +1 more source

Terazosin and propranolol as blockers to the deleterious effect of nicotine in a random skin flap, in the rat Terazosina e propanolol como bloqueadores do efeito deletério da nicotina em um retalho cutâneo randômico, no rato

Acta Cirúrgica Brasileira, 2004
PURPOSE: To evaluate the effect of Terazosin and Propranolol on the prevention of necrosis induced by nicotine, in a random skin flap. METHODS: This study utilized 32 adult male Wistar-EPM rats divided, at random, into four groups of eight animals each ...
Andre V. Fonseca, Lydia Masako Ferreira, Heitor C. Gomes, Sandro Percário   +3 more
doaj   +1 more source