Results 41 to 50 of about 7,105 (317)

Oral absorption and drug interaction kinetics of moxifloxacin in an animal model of weightlessness

Scientific Reports, 2021
To investigate the effect of simulated weightlessness on the pharmacokinetics of orally administered moxifloxacin and the antacid Maalox or the antidiarrheal Pepto-Bismol using a tail-suspended (TS) rat model of microgravity.
Dong Liang, Jing Ma, Bo Wei
doaj   +1 more source

Artificial gravity as a countermeasure for mitigating physiological deconditioning during long-duration space missions

Frontiers in Systems Neuroscience, 2015
In spite of the experience gained in human space flight since Yuri Gagarin’s historical flight in 1961, there has yet to be identified a completely effective countermeasure for mitigating the effects of weightlessness on humans. Were astronauts to embark
Gilles eClement, Angie eBukley, William ePaloski   +2 more
doaj   +1 more source

Impact of microgravity on retinal neuroimmune responses and visual dysfunction in rats [PDF]

International Journal of Ophthalmology
AIM: To analyze visual dysfunction in rats under simulated weightlessness (SW) by examining trans-laminar cribrosa pressure difference (TLCPD) and neuroimmune responses.
Jin-Shuo Liu, Nai-Qin Yan, Ying-Yan Mao, Chen Xin, Da-Peng Mou, Xin-Xiao Gao, Jia Guo, Ning-Li Wang, Si-Quan Zhu   +8 more
doaj   +1 more source

Microgravity and Musculoskeletal Health: What Strategies Should Be Used for a Great Challenge?

Life, 2023
Space colonization represents the most insidious challenge for mankind, as numerous obstacles affect the success of space missions. Specifically, the absence of gravitational forces leads to systemic physiological alterations, with particular emphasis on
Roberto Bonanni, Ida Cariati, Mario Marini, Umberto Tarantino, Virginia Tancredi   +4 more
doaj   +1 more source

Simulated Microgravity Using a Rotary Culture System Compromises the In Vitro Development of Mouse Preantral Follicles. [PDF]

PLoS ONE, 2016
Growing cells in simulated weightlessness condition might be a highly promising new technique to maintain or generate tissue constructs in a scaffold-free manner.
Shen Zhang, Dahan Zheng, Yonggen Wu, Wei Lin, Zaichong Chen, Luhe Meng, Jun Liu, Ying Zhou   +7 more
doaj   +1 more source

Modeling the Impact of Microgravity at the Cellular Level: Implications for Human Disease

Frontiers in Cell and Developmental Biology, 2020
A lack of gravity experienced during space flight has been shown to have profound effects on human physiology including muscle atrophy, reductions in bone density and immune function, and endocrine disorders.
Peta Bradbury, Hanjie Wu, Jung Un Choi, Alan E. Rowan, Hongyu Zhang, Kate Poole, Jan Lauko, Joshua Chou   +7 more
doaj   +1 more source

YAP Inhibition Alleviates Simulated Microgravity-Induced Mesenchymal Stem Cell Senescence via Targeting Mitochondrial Dysfunction

Antioxidants, 2023
Weightlessness in space leads to bone loss, muscle atrophy, and impaired immune defense in astronauts. Mesenchymal stem cells (MSCs) play crucial roles in maintaining the homeostasis and function of the tissue.
Wenjun Lv, Xiufen Peng, Yun Tu, Yisong Shi, Guanbin Song, Qing Luo   +5 more
doaj   +1 more source

Simulating Extreme Environmental Conditions via Mental Imagery: The Case of Microgravity and Weight Estimation

Frontiers in Psychology, 2022
Mental imagery can be used for recreating an extreme environment experience. Here we assessed whether microgravity effects over cognition, that typically occur during a space mission, may be reproduced via mental imagery.
Matteo Gatti, Rocco Palumbo, Alberto Di Domenico, Nicola Mammarella   +3 more
doaj   +1 more source

Lipid Signalling in Human Immune Response and Bone Remodelling under Microgravity

Applied Sciences, 2020
Since the first Apollo mission in 1969, microgravity has been linked to many alterations of astronauts’ physiology, among which immunosuppression, altered inflammation and bone loss represent relevant examples.
Marina Fava, Alessandro Leuti, Mauro Maccarrone   +2 more
doaj   +1 more source

P‐glycoprotein modulates the fluidity gradient of the plasma membrane of multidrug resistant CHO cells

FEBS Letters, EarlyView.
To explore the impact of the overexpression of the multidrug‐transporter P‐glycoprotein (ABCB1) on membrane fluidity, we compared the transversal gradient of mobility and microviscosity in plasma membranes of drug‐sensitive Chinese hamster ovary cells (AuxB1) and their multidrug‐resistant derivatives (B30) using the fluorescent n‐(9‐anthroyloxy) fatty ...
Roger Busche, John R. Riordan, Burkhard Tümmler   +2 more
wiley   +1 more source