Results 41 to 50 of about 1,186,610 (361)

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

TET3 Mediates 5hmC Level and Promotes Tumorigenesis by Activating AMPK Pathway in Papillary Thyroid Cancer

International Journal of Endocrinology, 2022
Thyroid cancer is the most common endocrine malignant tumor. The accurate risk stratification and prognosis assessment is particularly important for patients with thyroid cancer, which can reduce the tumor recurrence rate, morbidity, and mortality ...
Jiadong Chi, Wei Zhang, Yigong Li, Jie Zhao, Xiangqian Zheng, Ming Gao   +5 more
doaj   +1 more source

Thyroid hormone levels within reference range are associated with heart rate, cardiac structure, and function in middle-aged men and women [PDF]

, 2013
Background: Triiodothyronine (T3) has many effects on the heart, and marked changes in cardiac function and structure occur in patients with (subclinical) thyroid disease. We investigated whether between-subject variation in thyroid hormone levels within
De Buyzere, Marc, Gillebert, Thierry, Kaufman, Jean, Rietzschel, Ernst, ROEF, GREET, Taes, Youri, Van daele, Caroline   +6 more
core   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

Postpartum thyroid function following LT4 treatment from infertility treatment to delivery in women with subclinical hypothyroidism or high-normal TSH: a retrospective study

BMC Endocrine Disorders
Background Levothyroxine (LT4) therapy is commonly initiated in women undergoing infertility treatment who have high-normal thyroid-stimulating hormone (TSH) levels (HN) or subclinical hypothyroidism (SCH).
Yuka Tsukamoto, Yoh Hidaka, Yoshiko Fukuda, Yuko Wada, Kazuyo Okamoto, Yasuyuki Okamoto   +5 more
doaj   +1 more source

The Efficacy of Low-Kilovoltage X-Rays Intraoperative Radiation as Boost for Breast Cancer: A Systematic Review and Meta-Analysis

The Breast Journal, 2023
Background. Intraoperative radiotherapy (IORT) is a novel promising technology that may replace external beam radiation therapy (EBRT) as boost for patients receiving breast-conserving surgery.
Yuanjian Fan, Ruiwan Chen, Ying Lu, Ying Lin, Yunjian Zhang, Nan Shao, Shenming Wang, Dahong Nie, Zhen Shan   +8 more
doaj   +1 more source

Analysis of tissue surrounding thyroid nodules by ultrasound digital images [PDF]

, 2015
Since US is not easily reproducible, the digital image analysis (IA) has been proposed so that the image evaluation is not subjective. In fact, IA meets the criteria of objectivity, accurateness, and reproducibility by a matrix of pixels whose value is ...
Andrioli M, BINI, FABIANO, Ceriani L, DRUDI, Francesco Maria, Giovanella L, LENZI, Andrea, MARINOZZI, Franco, ROMANELLI, Francesco, Thorel MF, Trimboli P, VALABREGA, Stefano   +10 more
core   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Diffuse sclerosing variant of thyroid carcinoma presenting as Hashimoto thyroiditis: a case report [Difuzno sklerozirajući oblik papilarnog karcinoma štitnjače nalik Hashimoto tireoiditisu: prikaz slučaja] [PDF]

, 2012
The aim of report is to present a case of a rare diffuse sclerosing variant of a papillary thyroid carcinoma. A 15-year old girl referred for ultrasound examination because of painless thyroid swelling lasting 10 days before.
Banek, Tomislav, Kusačić Kuna, Sanja, Prgomet, Drago, Trutin Ostović, Karmen, Vukasović, Anamarija   +4 more
core  

The Clinical Significance of Subclinical Thyroid Dysfunction. [PDF]

, 2008
Subclinical thyroid disease (SCTD) is defined as serum free T(4) and free T(3) levels within their respective reference ranges in the presence of abnormal serum TSH levels.
BIONDI, BERNADETTE, COOPER DS
core   +1 more source