Results 41 to 50 of about 2,474,824 (285)

Development of safe and effective indigenous intensive care unit ventilators for COVID-19 pandemic

Indian Journal of Respiratory Care, 2021
Severe acute respiratory syndrome-coronavirus 2 has spread rapidly worldwide infecting ≥4 million people including ≥2.9 million deaths and overwhelming health-care systems globally.
Anup Daniel Varghese, Sanjay Orathi Patangi, Kumar G Belani, Muralidhar Kanchi   +3 more
doaj   +1 more source

Effect of dynamic random leaks on the monitoring accuracy of home mechanical ventilators: a bench study

BMC Pulmonary Medicine, 2013
BackgroundSo far, the accuracy of tidal volume (VT) and leak measures provided by the built-in software of commercial home ventilators has only been tested using bench linear models with fixed calibrated and continuous leaks.
A. Sogo, J. Montanyà, E. Monso, L. Blanch, X. Pomares, M. Luján   +5 more
semanticscholar   +1 more source

Critical Care Nursing in a Resource-Constrained Setting: A Qualitative Study of Critical Care Nurses’ Experiences Caring for Patients on Mechanical Ventilation

SAGE Open Nursing, 2023
Introduction Managing a patient on mechanical ventilation is a vital aspect of clinical scope in intensive and critical care units. In addition, it is a highly technical, intricate, dynamic task requiring extensive knowledge and skills.
Paulus Mukuve PGDip, Vistolina Nuuyoma PhD   +1 more
doaj   +1 more source

Actual performance of mechanical ventilators in ICU: a multicentric quality control study

Medical devices, 2012
Even if the performance of a given ventilator has been evaluated in the laboratory under very well controlled conditions, inappropriate maintenance and lack of long-term stability and accuracy of the ventilator sensors may lead to ventilation errors in ...
L. Govoni, R. Dellaca’, Ó. Peñuelas, G. Bellani, A. Artigas, M. Ferrer, D. Navajas, A. Pedotti, R. Farré   +8 more
semanticscholar   +1 more source

The mechanics of mechanical ventilation [PDF]

Revista Médica de Minas Gerais, 2014
The Ventilator has represented an advance in the respiratory support for patients on anesthesia and intensive care. The ventilatory support increases the chance of survival in patients with respiratory failure, and / or major surgical procedures. This paper consists of a summary of advances in the ventilatory support, in describing the physiological ...
Renan Murta Soares de Almeida, Aline Siqueira Melo, Cláudio Dornas de Oliveira   +2 more
openaire   +1 more source

A Novel Mixed Finite/Infinite Dimensional Port–Hamiltonian Model of a Mechanical Ventilator

Computation
Mechanical ventilation is a life-saving treatment for critically ill patients who are struggling to breathe independently due to injury or disease. Globally, per year, there has always been a large number of individuals who have required mechanical ...
Milka C. I. Madahana, John E. D. Ekoru, Otis T. C. Nyandoro   +2 more
doaj   +1 more source

Trauma and Critical Care for the Senior Medical Student Entering Surgery

MedEdPORTAL, 2014
Introduction Skills to aid in the management of trauma patients and critically ill surgical patients in the intensive care setting are important topics that are not uniformly covered in medical schools.
Mara Antonoff, Courtney Green, Jonathan D'Cunha   +2 more
doaj   +1 more source

MET variants with activating N‐lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation

Molecular Oncology, EarlyView.
MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin, Audrey Vinchent, Marie Fernandes, Isabelle Damour, Agathe Laratte, Rémi Tellier, Gabriella O. Estevam, Jean‐Pascal Meneboo, Céline Villenet, Clotilde Descarpentries, James S. Fraser, Martin Figeac, Alexis B. Cortot, Etienne Rouleau, David Tulasne   +14 more
wiley   +1 more source

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source