Results 1 to 10 of about 978,564 (384)
Pathophysiology of Atherosclerosis
International Journal of Molecular Sciences, 2022 Atherosclerosis is the main risk factor for cardiovascular disease (CVD), which is the leading cause of mortality worldwide. Atherosclerosis is initiated by endothelium activation and, followed by a cascade of events (accumulation of lipids, fibrous elements, and calcification), triggers the vessel narrowing and activation of inflammatory pathways. The
Shifa Jebari-Benslaiman +7 more
openaire +5 more sources
Nature Reviews Disease Primers, 2019 Atherosclerosis, the formation of fibrofatty lesions in the artery wall, causes much morbidity and mortality worldwide, including most myocardial infarctions and many strokes, as well as disabling peripheral artery disease. Development of atherosclerotic lesions probably requires low-density lipoprotein, a particle that carries cholesterol through the ...
Peter, Libby +7 more
semanticscholar +5 more sources
Lipoproteins and Atherosclerosis [PDF]
Journal of Gerontology, 1951 Author(s): Gofman, John W.; Lindgren, Frank T.; Jones, Hardin B.; Lyon, Thomas P.; Strisower, Beverly.
John W. Gofman +4 more
openalex +5 more sources
GSDME-mediated pyroptosis promotes the progression and associated inflammation of atherosclerosis
Nature Communications, 2023 Macrophages have been shown to have an important function in atherosclerosis. Here the authors show that, in human atherosclerotic plaques and mouse models, GSDME and pyroptosis promote atherosclerosis and inhibition of these pathways could reduce ...
Yuanyuan Wei +8 more
semanticscholar +1 more source
Atherosclerosis in frailty: Not frailty in atherosclerosis [PDF]
Atherosclerosis, 2017 na
GUARALDI, Giovanni, Raggi, Paolo
openaire +3 more sources
Wall shear stress and its role in atherosclerosis
Frontiers in Cardiovascular Medicine, 2023 Atherosclerosis (AS) is the major form of cardiovascular disease and the leading cause of morbidity and mortality in countries around the world. Atherosclerosis combines the interactions of systemic risk factors, haemodynamic factors, and biological ...
Manli Zhou +8 more
semanticscholar +1 more source
Atherosclerosis and Autoimmunity [PDF]
Mediators of Inflammation, 2018 Abstract Despite a decline in mortality rates in several countries, cardiovascular disease remains the leading cause of death responsible for approximately half of all deaths on the continent. Coronary artery disease and stroke are often the result of acute complications of atherosclerosis (AS) and atherothrombosis.
Francesca Romana Spinelli +4 more
openaire +3 more sources
Inflammation and atherosclerosis: signaling pathways and therapeutic intervention
Signal Transduction and Targeted Therapy, 2022 Atherosclerosis is a chronic inflammatory vascular disease driven by traditional and nontraditional risk factors. Genome-wide association combined with clonal lineage tracing and clinical trials have demonstrated that innate and adaptive immune responses
Peng Kong +5 more
semanticscholar +1 more source
The Role of Oxidative Stress in Atherosclerosis
Cells, 2022 Atherosclerosis is a chronic inflammatory disease of the vascular system and is the leading cause of cardiovascular diseases worldwide. Excessive generation of reactive oxygen species (ROS) leads to a state of oxidative stress which is a major risk ...
M. Batty, M. Bennett, E. Yu
semanticscholar +1 more source
Journal of Lipid Research, 1994 A novel mutation of low density lipoprotein (LDL)-receptor gene was found in an Italian family hypercholesterolemia (FH) patient during a screening of 300 FH patients.
S Bertolini +9 more
doaj +1 more source