Dexamethasone in acute stroke. [PDF]
BMJ, 1978 Over 13 months 118 patients admitted to hospital with acute stroke were allocated at random to treatment with either dexamethasone or placebo. At one year there was no significant difference in the numbers of survivors or in the quality of life between the two groups.
G P Mulley +2 more
+10 more sources
Transcriptional Co‐Activator With PDZ Binding Motif (TAZ) Inhibits Dexamethasone‐Induced Muscle Atrophy via mTOR Signalling [PDF]
Journal of Cachexia, Sarcopenia and MuscleBackground Glucocorticoid therapy has a beneficial effect in several diseases, but chronic treatment has adverse effects, including muscle atrophy, which refers to the gradual decrease in muscle mass, size and strength.
Kyung Min Kim +10 more
doaj +2 more sources
Advanced Biomedical ResearchBackground: Common complications including stridor, laryngospasm, and bronchospasm are important in patients undergoing general anesthesia. Dexamethasone, lidocaine, and ketamine could have significant roles in reducing these complications. Here we aimed
Morteza Heidari +3 more
doaj +3 more sources
Improving patient recruitment to randomised trials can be cost-effective: A case-study of dexamethasone from the RECOVERY trial. [PDF]
PLoS ONEBackgroundThe RECOVERY trial assessed the effectiveness of treatments on preventing severe outcomes from COVID-19 disease in hospitalised patients from 176 NHS hospitals. Clinical benefits of Dexamethasone were observed for hospitalised COVID-19 patients.
Athanasios Gkekas +3 more
doaj +2 more sources
The Effect of the Timing of Dexamethasone Administration in Patients with COVID-19 Pneumonia [PDF]
Tuberculosis and Respiratory Diseases, 2021 Background Despite the proven benefits of dexamethasone in hospitalized coronavirus disease 2019 (COVID-19) patients, the optimum time for the administration of dexamethasone is unknown.
Hyun Woo Lee +4 more
doaj +1 more source
Nursing, 2020 Dexamethason is een corticosteroïd: het remt ontstekingen en vermindert overgevoeligheidsreacties. Ook wordt het ingezet bij de behandeling van covid-19. Maak de toets en verdien 1 accreditatiepunt.
de Graaf, Linda, Aarts, Francine
openaire +1 more source
An in silico drug repurposing pipeline to identify drugs with the potential to inhibit SARS-CoV-2 replication [PDF]
Informatics in Medicine Unlocked (2023): 101387, 2021 Drug repurposing provides an opportunity to redeploy drugs, which ideally are already approved for use in humans, for the treatment of other diseases. For example, the repurposing of dexamethasone and baricitinib has played a crucial role in saving patient lives during the ongoing SARS-CoV-2 pandemic.
arxiv +1 more source
Acute Activation of Metabolic Syndrome Components in Pediatric Acute Lymphoblastic Leukemia Patients Treated with Dexamethasone. [PDF]
PLoS ONE, 2016 Although dexamethasone is highly effective in the treatment of pediatric acute lymphoblastic leukemia (ALL), it can cause serious metabolic side effects.
Lidewij T Warris +9 more
doaj +1 more source
Dexamethasone pretreatment impairs the thymidylate synthase inhibition mediated flare in thymidine salvage pathway activity in non-small cell lung cancer. [PDF]
PLoS ONE, 2018 INTRODUCTION:Successful inhibition of thymidylate synthase (TS) by pemetrexed, a TS inhibitor, results in a reproducible transient burst or "flare" in thymidine salvage pathway activity at 2 hrs.
Xiao Chen, Yizeng Yang, Sharyn I Katz
doaj +1 more source