The Cap-Snatching SFTSV Endonuclease Domain Is an Antiviral Target [PDF]
Cell Reports, 2020 Summary: Severe fever with thrombocytopenia syndrome virus (SFTSV) is a tick-borne virus with 12%–30% case mortality rates and is related to the Heartland virus (HRTV) identified in the United States.
Wenjie Wang +11 more
doaj +3 more sources
The endonuclease Cue2 cleaves mRNAs at stalled ribosomes during No Go Decay
eLife, 2019 Translation of problematic sequences in mRNAs leads to ribosome collisions that trigger a series of quality control events including ribosome rescue, degradation of the stalled nascent polypeptide, and targeting of the mRNA for decay (No Go Decay or NGD).
Karole N D'Orazio +5 more
doaj +2 more sources
The mismatch repair and meiotic recombination endonuclease Mlh1-Mlh3 is activated by polymer formation and can cleave DNA substrates in trans. [PDF]
PLoS Biology, 2017 Crossing over between homologs is initiated in meiotic prophase by the formation of DNA double-strand breaks that occur throughout the genome. In the major interference-responsive crossover pathway in baker's yeast, these breaks are resected to form 3 ...
Carol M Manhart +5 more
doaj +2 more sources
A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity
Science, 2012 M. Jinek +5 more
semanticscholar +3 more sources
Cluster J Mycobacteriophages: Intron Splicing in Capsid and Tail Genes [PDF]
, 2013 Bacteriophages isolated on Mycobacterium smegmatis mc2155 represent many distinct genomes sharing little or no DNA sequence similarity. The genomes are architecturally mosaic and are replete with genes of unknown function.
Best, AA +17 more
core +15 more sources
An Inducible Microbacterium Prophage vB_MoxS-R1 Represents a Novel Lineage of Siphovirus
Viruses, 2022 Lytic and lysogenic infections are the main strategies used by viruses to interact with microbial hosts. The genetic information of prophages provides insights into the nature of phages and their potential influences on hosts.
Hongrui Zheng +6 more
doaj +1 more source
Dynamics and Conformations of a Full-Length CRESS-DNA Replicase
Viruses, 2023 Circular Rep-encoding single-stranded DNA (CRESS-DNA) viruses encode for a Replicase (Rep) that is essential for viral replication. Rep is a helicase with three domains: an endonuclease, an oligomeric, and an ATPase domain (ED, OD, and AD).
Elvira Tarasova, Reza Khayat
doaj +1 more source
Fanzor is a eukaryotic programmable RNA-guided endonuclease
Nature, 2023 Fanzor is shown to be an RNA-guided DNA endonuclease, demonstrating that such endonucleases are found in all domains of life and indicating a potential new tool for genome engineering applications.
M. Saito +9 more
semanticscholar +1 more source
Mutational Effects of Mobile Introns on the Mitochondrial Genomes of Metschnikowia Yeasts
Frontiers in Genetics, 2021 It has been argued that DNA repair by homologous recombination in the context of endonuclease-mediated cleavage can cause mutations. To better understand this phenomenon, we examined homologous recombination following endonuclease cleavage in a native ...
Scout R. L. Thompson +3 more
doaj +1 more source
Transposon-associated TnpB is a programmable RNA-guided DNA endonuclease
Nature, 2021 Transposition has a key role in reshaping genomes of all living organisms1. Insertion sequences of IS200/IS605 and IS607 families2 are among the simplest mobile genetic elements and contain only the genes that are required for their transposition and its
Tautvydas Karvelis +8 more
semanticscholar +1 more source