Results 1 to 10 of about 271,229 (377)
The Cap-Snatching SFTSV Endonuclease Domain Is an Antiviral Target [PDF]
Cell Reports, 2020 Summary: Severe fever with thrombocytopenia syndrome virus (SFTSV) is a tick-borne virus with 12%–30% case mortality rates and is related to the Heartland virus (HRTV) identified in the United States.
Wenjie Wang +11 more
doaj +2 more sources
High-Resolution Structure of the N-Terminal Endonuclease Domain of the Lassa Virus L Polymerase in Complex with Magnesium Ions [PDF]
, 2014 Lassa virus (LASV) causes deadly hemorrhagic fever disease for which there are no vaccines and limited treatments. LASV-encoded L polymerase is required for viral RNA replication and transcription.
Dong, Changjiang +6 more
core +11 more sources
Mutational Effects of Mobile Introns on the Mitochondrial Genomes of Metschnikowia Yeasts
Frontiers in Genetics, 2021 It has been argued that DNA repair by homologous recombination in the context of endonuclease-mediated cleavage can cause mutations. To better understand this phenomenon, we examined homologous recombination following endonuclease cleavage in a native ...
Scout R. L. Thompson +3 more
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An Inducible Microbacterium Prophage vB_MoxS-R1 Represents a Novel Lineage of Siphovirus
Viruses, 2022 Lytic and lysogenic infections are the main strategies used by viruses to interact with microbial hosts. The genetic information of prophages provides insights into the nature of phages and their potential influences on hosts.
Hongrui Zheng +6 more
doaj +1 more source
Dynamics and Conformations of a Full-Length CRESS-DNA Replicase
Viruses, 2023 Circular Rep-encoding single-stranded DNA (CRESS-DNA) viruses encode for a Replicase (Rep) that is essential for viral replication. Rep is a helicase with three domains: an endonuclease, an oligomeric, and an ATPase domain (ED, OD, and AD).
Elvira Tarasova, Reza Khayat
doaj +1 more source
A non-canonical role for the EDC4 decapping factor in regulating MARF1-mediated mRNA decay
eLife, 2020 EDC4 is a core component of processing (P)-bodies that binds the DCP2 decapping enzyme and stimulates mRNA decay. EDC4 also interacts with mammalian MARF1, a recently identified endoribonuclease that promotes oogenesis and contains a number of RNA ...
William R Brothers +3 more
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Human MUS81: A Fence-Sitter in Cancer
Frontiers in Cell and Developmental Biology, 2021 MUS81 complex, exhibiting endonuclease activity on specific DNA structures, plays an influential part in DNA repair. Research has proved that MUS81 is dispensable for embryonic development and cell viability in mammals.
Sisi Chen +7 more
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Frontiers in Microbiology, 2020 Influenza virus RNA-dependent RNA polymerase (vRdRp) does not have capping activity and relies on the capped RNAs produced by the host RNA polymerase II (RNAPII).
Ao Hu +10 more
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Alternative end-joining in BCR gene rearrangements and translocations
Acta Biochimica et Biophysica Sinica, 2022 Programmed DNA double-strand breaks (DSBs) occur during antigen receptor gene recombination, namely V(D)J recombination in developing B lymphocytes and class switch recombination (CSR) in mature B cells.
Bai Wanyu +3 more
doaj +1 more source
Actin-Resistant DNase1L2 as a Potential Therapeutics for CF Lung Disease
Biomolecules, 2021 In cystic fibrosis (CF), the accumulation of viscous lung secretions rich in DNA and actin is a major cause of chronic inflammation and recurrent infections leading to airway obstruction.
Danila Delfino +9 more
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