Results 1 to 10 of about 1,687,854 (353)

Adaptive Laboratory Evolution Reveals the Selenium Efflux Process To Improve Selenium Tolerance Mediated by the Membrane Sulfite Pump in Saccharomyces cerevisiae

open access: yesMicrobiology Spectrum, 2023
Selenium (Se) is a micronutrient in most eukaryotes, and Se-enriched yeast is the most common selenium supplement. However, selenium metabolism and transport in yeast have remained unclear, greatly hindering the application of this element.
Ao Gong   +4 more
doaj   +1 more source

NLK is required for Ras/ERK/SRF/ELK signaling to tune skeletal muscle development by phosphorylating SRF and antagonizing the SRF/MKL pathway

open access: yesCell Death Discovery, 2022
Serum response factor (SRF) regulates differentiation and proliferation by binding to RhoA-actin-activated MKL or Ras-MAPK-activated ELK transcriptional coactivators, but the molecular mechanisms responsible for SRF regulation remain unclear.
Shang-Ze Li   +12 more
doaj   +1 more source

Setd4 controlled quiescent c-Kit+ cells contribute to cardiac neovascularization of capillaries beyond activation

open access: yesScientific Reports, 2021
Blood vessels in the adult mammal exist in a highly organized and stable state. In the ischemic heart, limited expansion capacity of the myocardial vascular bed cannot satisfy demands for oxygen supply and the myocardium eventually undergoes irreversible
Sheng Xing   +7 more
doaj   +1 more source

Whole genome-wide chromosome fusion and new gene birth in the Monopterus albus genome

open access: yesCell & Bioscience, 2020
Background Teleost fishes account for over half of extant vertebrate species. A core question in biology is how genomic changes drive phenotypic diversity that relates to the origin of teleost fishes.
Yibin Cheng   +13 more
doaj   +1 more source

SETD4-expressing cells contribute to pancreatic development and response to cerulein induced pancreatitis injury

open access: yesScientific Reports, 2021
In the adult pancreas, the presence of progenitor or stem cells and their potential involvement in homeostasis and regeneration remains unclear. Here, we identify that SET domain-containing protein 4 (SETD4), a histone lysine methyltransferase, is ...
Jin-Ze Tian   +7 more
doaj   +1 more source

The pH-Responsive Transcription Factors YlRim101 and Mhy1 Regulate Alkaline pH-Induced Filamentation in the Dimorphic Yeast Yarrowia lipolytica

open access: yesmSphere, 2021
The regulatory mechanism that governs pH-regulated filamentation is not clear in dimorphic fungi except in Candida albicansYarrowia lipolyticaC ...
Tao Shu   +4 more
doaj   +1 more source

Loss-of-function of sox3 causes follicle development retardation and reduces fecundity in zebrafish

open access: yesProtein & Cell, 2018
Folliculogenesis is essential for production of female gametes in vertebrates. However, the molecular mechanisms underlying follicle development, particularly apoptosis regulation in ovary, remain elusive. Here, we generated sox3 knockout zebrafish lines
Qiang Hong   +7 more
doaj   +1 more source

Cellular fate of intersex differentiation

open access: yesCell Death and Disease, 2021
Infertile ovotestis (mixture of ovary and testis) often occurs in intersex individuals under certain pathological and physiological conditions. However, how ovotestis is formed remains largely unknown.
Xin Wang   +6 more
doaj   +1 more source

Characterization of Hsp17, a Novel Small Heat Shock Protein, in Sphingomonas melonis TY under Heat Stress

open access: yesMicrobiology Spectrum, 2023
Bacteria are constantly exposed to a variety of environmental stresses. Temperature is considered one of the most important environmental factors affecting microbial growth and survival.
Yihan Wang   +5 more
doaj   +1 more source

The hyper-activation of transcriptional enhancers in breast cancer

open access: yesClinical Epigenetics, 2019
Background Activation of transcription enhancers, especially super-enhancers, is one of the critical epigenetic features of tumorigenesis. However, very few studies have systematically identified the enhancers specific in cancer tissues. Methods Here, we
Qing-Lan Li   +8 more
doaj   +1 more source

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