Results 1 to 10 of about 1,687,854 (353)
Selenium (Se) is a micronutrient in most eukaryotes, and Se-enriched yeast is the most common selenium supplement. However, selenium metabolism and transport in yeast have remained unclear, greatly hindering the application of this element.
Ao Gong+4 more
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Serum response factor (SRF) regulates differentiation and proliferation by binding to RhoA-actin-activated MKL or Ras-MAPK-activated ELK transcriptional coactivators, but the molecular mechanisms responsible for SRF regulation remain unclear.
Shang-Ze Li+12 more
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Blood vessels in the adult mammal exist in a highly organized and stable state. In the ischemic heart, limited expansion capacity of the myocardial vascular bed cannot satisfy demands for oxygen supply and the myocardium eventually undergoes irreversible
Sheng Xing+7 more
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Whole genome-wide chromosome fusion and new gene birth in the Monopterus albus genome
Background Teleost fishes account for over half of extant vertebrate species. A core question in biology is how genomic changes drive phenotypic diversity that relates to the origin of teleost fishes.
Yibin Cheng+13 more
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In the adult pancreas, the presence of progenitor or stem cells and their potential involvement in homeostasis and regeneration remains unclear. Here, we identify that SET domain-containing protein 4 (SETD4), a histone lysine methyltransferase, is ...
Jin-Ze Tian+7 more
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The regulatory mechanism that governs pH-regulated filamentation is not clear in dimorphic fungi except in Candida albicansYarrowia lipolyticaC ...
Tao Shu+4 more
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Loss-of-function of sox3 causes follicle development retardation and reduces fecundity in zebrafish
Folliculogenesis is essential for production of female gametes in vertebrates. However, the molecular mechanisms underlying follicle development, particularly apoptosis regulation in ovary, remain elusive. Here, we generated sox3 knockout zebrafish lines
Qiang Hong+7 more
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Cellular fate of intersex differentiation
Infertile ovotestis (mixture of ovary and testis) often occurs in intersex individuals under certain pathological and physiological conditions. However, how ovotestis is formed remains largely unknown.
Xin Wang+6 more
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Bacteria are constantly exposed to a variety of environmental stresses. Temperature is considered one of the most important environmental factors affecting microbial growth and survival.
Yihan Wang+5 more
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The hyper-activation of transcriptional enhancers in breast cancer
Background Activation of transcription enhancers, especially super-enhancers, is one of the critical epigenetic features of tumorigenesis. However, very few studies have systematically identified the enhancers specific in cancer tissues. Methods Here, we
Qing-Lan Li+8 more
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