Role of Peroxynitrite in the Pathogenesis of Parkinson’s Disease and Its Fluorescence Imaging-Based Detection [PDF]
BiosensorsParkinson’s disease (PD) is the second most common neurodegenerative disorder, affecting the lives of millions of people worldwide. Although the mechanism underlying PD pathogenesis is largely undefined, increasing evidence indicates that oxidative and ...
Jiye Lv +5 more
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Cytomegalovirus-induced peroxynitrite promotes virus entry and contributes to pathogenesis in a murine model of infection [PDF]
mBioThere are no licensed vaccines for human cytomegalovirus (HCMV), and current antiviral drugs that target viral proteins are toxic and prone to resistance.
Pragati S. Amratia +6 more
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Homogenous catalysis of peroxynitrite conversion to nitrate by diaryl selenide: a theoretical investigation of the reaction mechanism [PDF]
Frontiers in ChemistryQuenching peroxynitrite (a reactive oxidant species) is a vital process in biological systems and environmental chemistry as it maintains redox balance and mitigates damaging effects in living cells and the environment.
Yuan Xue +5 more
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The Ubiquity of the Reaction of the Labile Iron Pool That Attenuates Peroxynitrite-Dependent Oxidation Intracellularly [PDF]
BiomoleculesAlthough the labile iron pool (LIP) biochemical identity remains a topic of debate, it serves as a universal homeostatically regulated and essential cellular iron source.
Gabriel Simonetti da Silva +2 more
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Modulation of Myocardial Contraction by Peroxynitrite [PDF]
Frontiers in Physiology, 2012 Peroxynitrite is a potent oxidant that is quickly emerging as a crucial modulator of myocardial function. This review will focus on the regulation of myocardial contraction by peroxynitrite during health and disease, with a specific emphasis on ...
Mark eKohr +3 more
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Frontiers in Cellular Neuroscience, 2022 Glutathione peroxidase 1 (GPX1) is a crucial antioxidant enzyme that prevented the harmful accumulation of intra-cellular hydrogen peroxide. GPX1 might contribute in limiting cochlear damages associated with aging or acoustic overexposure, but the ...
Xue Wang +15 more
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Protection against peroxynitrite [PDF]
FEBS Letters, 1999 Peroxynitrite formed in vivo from superoxide and nitric oxide can mediate oxidation, nitration, or nitrosation reactions, leading to impaired function, toxicity, and alterations in signaling pathways. Protection against peroxynitrite is important for defense of normal tissue, especially during inflammation.
Helmut Sies +2 more
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Antioxidants, 2020 Thiol peroxidases (TP) are ubiquitous and abundant antioxidant proteins of the peroxiredoxin and glutathione peroxidase families that can catalytically and rapidly reduce biologically relevant peroxides, such as hydrogen peroxide and peroxynitrite ...
André Luís Condeles +4 more
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FeTPPS, a Peroxynitrite Decomposition Catalyst, Ameliorates Nitrosative Stress in Human Spermatozoa
Antioxidants, 2023 Excessive levels of reactive nitrogen species (RNS), such as peroxynitrite, promote nitrosative stress, which is an important cause of impaired sperm function.
Pamela Uribe +9 more
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The Labile Iron Pool Reacts Rapidly and Catalytically with Peroxynitrite
Biomolecules, 2021 While investigating peroxynitrite-dependent oxidation in murine RAW 264.7 macrophage cells, we observed that removal of the Labile Iron Pool (LIP) by chelation increases the intracellular oxidation of the fluorescent indicator H2DCF, so we concluded that
André Luís Condeles +1 more
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