Results 1 to 10 of about 898 (95)
Release of choline by phospholipase D and a related phosphoric diester hydrolase in human erythrocytes. 1H spin-echo n.m.r. studies [PDF]
Biochemical Journal, 1992 A previously detected phosphatidylcholine-specific phospholipase D from lysates of human red blood cells has been further characterized by 1H spin-echo n.m.r. spectroscopy.
Hartmut Selle +2 more
openalex +2 more sources
Development of covalent inhibitors: Principle, design, and application in cancer
MedComm – Oncology, Volume 2, Issue 4, December 2023., 2023 The noncysteine covalent inhibitors are a class of small molecule inhibitors that can bind irreversibly to their target enzymes through covalent bonding with noncysteine residues. They have shown promise as potential therapeutics for a variety of diseases, including cancer, infectious diseases, and autoimmune disorders. Examples of noncysteine covalent
Lang Zheng +6 more
wiley +1 more source
Advanced Materials Interfaces, Volume 10, Issue 8, March 15, 2023., 2023 Although various types of biopharmaceuticals have presented multidimensional therapeutic effects in spinal cord injury (SCI), the rigorous microenvironment after SCI impedes their capacity. Biomaterial‐based defenders (BBDs) are designed to protect biopharmaceuticals passively or actively to reduce their inactivation and loss.
Xunqi Zhang +3 more
wiley +1 more source
Evolutionary Applications, Volume 16, Issue 2, Page 408-427, February 2023., 2023 Abstract For hundreds of years, the color diversity of Mollusca shells has been a topic of interest for humanity. However, the genetic control underlying color expression is still poorly understood in mollusks. The pearl oyster Pinctada margaritifera is increasingly becoming a biological model to study this process due to its ability to produce a large
Pierre‐Louis Stenger +4 more
wiley +1 more source
Cancer Medicine, Volume 11, Issue 23, Page 4411-4421, December 2022., 2022 Integration of bioinformatics analysis and experimental validation, this study provides novel insights into miRNA related networks in LUAD. Plasma exosomal hsa‐miR‐103b, hsa‐miR‐29c‐5p and hsa‐miR‐877‐5p may be used as diagnostic biomarkers for early LUAD.
Jing Wu +6 more
wiley +1 more source
Enzymatic Kinetic Resolution by Addition of Oxygen
Angewandte Chemie, Volume 133, Issue 9, Page 4482-4495, February 23, 2021., 2021 Enzymatic oxidative kinetic resolutions (OKR), in which a new oxygen atom is inserted into the substrate, are highly effective for the synthesis of enantioenriched oxygen‐containing compounds. This Minireview discusses selected enzyme classes that can achieve OKR, biological advancements and protein development, and the use of these key enantioenriched
Lucy A. Harwood +2 more
wiley +2 more sources
Targeting epigenetic regulators for inflammation: Mechanisms and intervention therapy
MedComm, Volume 3, Issue 4, December 2022., 2022 Innate immune system responds to stimulus (bacteria, virus, lipopolysaccharide) firstly; nevertheless, exaggerated immune response results in a variety of inflammation‐related diseases. Epigenetic modifications including chromatin remodeling, DNA modifications, RNA modifications, Histone modifications, noncoding RNA, and regulate multiple signaling ...
Su Zhang +8 more
wiley +1 more source
Cancer Science, Volume 113, Issue 12, Page 4082-4091, December 2022., 2022 We recently reported that HMGB1 showed a negative impact on anti‐tumor immunity, however, a positive role of HMGB1 in the initiation of innate and subsequent adaptive immunity has also been shown. In this study, we found that the suppression of HMGB1 in the tumor microenvironment does not inhibit the induction of neoantigen‐specific immunity.
Kayoko Waki, Miyako Ozawa, Akira Yamada
wiley +1 more source
Molecular Ecology, Volume 31, Issue 18, Page 4707-4725, September 2022., 2022 Abstract Acidification‐induced changes in neurological function have been documented in several tropical marine fishes. Here, we investigate whether similar patterns of neurological impacts are observed in a temperate Pacific fish that naturally experiences regular and often large shifts in environmental pH/pCO2.
Jason A. Toy +5 more
wiley +1 more source
Environmental Microbiology, Volume 24, Issue 5, Page 2259-2269, May 2022., 2022 Summary Dissolved organic phosphorus (DOP) is a critical nutritional resource for marine microbial communities. However, the relative bioavailability of different types of DOP, such as phosphomonoesters (P‐O‐C) and phosphoanhydrides (P‐O‐P), is poorly understood. Here we assess the utilization of these P sources by a representative bacterial copiotroph,
Jamee C. Adams +4 more
wiley +1 more source