Results 1 to 10 of about 1,734,521 (378)

Protein degradation in auxin response. [PDF]

Plant Cell
Abstract The signaling molecule auxin sits at the nexus of plant biology where it coordinates essentially all growth and developmental processes. Auxin molecules are transported throughout plant tissues and are capable of evoking highly specific physiological responses by inducing various molecular pathways.
de Roij M, Borst JW, Weijers D.
europepmc   +4 more sources

Intrinsic signaling pathways modulate targeted protein degradation [PDF]

Nature Communications
Targeted protein degradation is a groundbreaking modality in drug discovery; however, the regulatory mechanisms are still not fully understood. Here, we identify cellular signaling pathways that modulate the targeted degradation of the anticancer target ...
Yuki Mori, Yoshino Akizuki, Rikuto Honda, Miyu Takao, Ayaka Tsuchimoto, Sota Hashimoto, Hiroaki Iio, Masakazu Kato, Ai Kaiho-Soma, Yasushi Saeki, Jun Hamazaki, Shigeo Murata, Toshikazu Ushijima, Naoko Hattori, Fumiaki Ohtake   +14 more
doaj   +2 more sources

Structure-based design of a phosphotyrosine-masked covalent ligand targeting the E3 ligase SOCS2

Nature Communications, 2023
The Src homology 2 (SH2) domain recognizes phosphotyrosine (pY) post translational modifications in partner proteins to trigger downstream signaling. Drug discovery efforts targeting the SH2 domains have long been stymied by the poor drug-like properties
Sarath Ramachandran, Nikolai Makukhin, Kevin Haubrich, Manjula Nagala, Beth Forrester, Dylan M. Lynch, Ryan Casement, Andrea Testa, Elvira Bruno, Rosaria Gitto, Alessio Ciulli   +10 more
doaj   +1 more source

Protein degradation in mitochondria [PDF]

Seminars in Cell & Developmental Biology, 2000
The biogenesis of mitochondria and the maintenance of mitochondrial functions depends on an autonomous proteolytic system in the organelle which is highly conserved throughout evolution. Components of this system include processing peptidases and ATP-dependent proteases, as well as molecular chaperone proteins and protein complexes with apparently ...
Kaser, M., Langer, T.
openaire   +4 more sources

Downregulation of Linc00173 increases BCL2 mRNA stability via the miR-1275/PROCA1/ZFP36L2 axis and induces acquired cisplatin resistance of lung adenocarcinoma

Journal of Experimental & Clinical Cancer Research, 2023
Background LINC00173 had been reported as a cisplatin (cis-diamminedichloroplatinum, DDP) chemotherapy-resistant inducer in small-cell lung cancer (SCLC) and lung squamous cell carcinoma (LUSC). This study aimed to display reverse data for LINC00173 as a
Xingyu Tao, Yang Li, Songqing Fan, Liyang Wu, Jianyang Xin, Yun Su, Xiaoyang Xian, Yingying Huang, Rongquan Huang, Weiyi Fang, Zhen Liu   +10 more
doaj   +1 more source

Redox control of protein degradation [PDF]

Redox Biology, 2015
Intracellular proteolysis is critical to maintain timely degradation of altered proteins including oxidized proteins. This review attempts to summarize the most relevant findings about oxidant protein modification, as well as the impact of reactive oxygen species on the proteolytic systems that regulate cell response to an oxidant environment: the ...
Pajares, Marta, Jiménez-Moreno, Natalia, Dias, Irundika H K, Debelec, Bilge, Vucetic, Milica, Fladmark, Kari E., Basaga, Huveyda, Ribaric, Samo, Milisav, Irina, Cuadrado Pastor, Antonio   +9 more
openaire   +10 more sources

CHD1L augments autophagy-mediated migration of hepatocellular carcinoma through targeting ZKSCAN3

Cell Death and Disease, 2021
Autophagy is an important biological process in normal cells. However, how it affects tumor progression still remains poorly understood. Herein, we demonstrated that the oncogenic protein Chromodomain-helicase-DNA-binding-protein 1-like gene (CHD1L ...
Xiaofeng Zhang, Yinshan Bai, Li Huang, Shanshan Liu, Yanxuan Mo, Wei Cheng, Guangliang Wang, Zhiming Cao, Xiaogang Chen, Huiqing Cui, Ling Qi, Lei Ma, Ming Liu, Xin-Yuan Guan, Ning-Fang Ma   +14 more
doaj   +1 more source

Mild‐Photothermal Effect Induced High Efficiency Ferroptosis‐Boosted‐Cuproptosis Based on Cu2O@Mn3Cu3O8 Nanozyme

Advanced Science, 2023
A core‐shell‐structured Cu2O@Mn3Cu3O8 (CMCO) nanozyme is constructed to serve as a tumor microenvironment (TME)‐activated copper ionophore to achieve safe and efficient cuproptosis.
Wei Chen, Wenyu Xie, Zhimin Gao, Chen Lin, Meiling Tan, Yaru Zhang, Zhiyao Hou   +6 more
doaj   +1 more source

Correction: TRPC6-dependent Ca2+ signaling mediates airway inflammation in response to oxidative stress via ERK pathway

Cell Death and Disease, 2020
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Qingzi Chen, Yubo Zhou, Lifen Zhou, Zhaodi Fu, Chuntao Yang, Lei Zhao, Shuni Li, Yan Chen, Yousen Wu, Zhenwei Ling, Yufeng Wang, Jianrong Huang, Jianhua Li   +12 more
doaj   +1 more source

A selective and orally bioavailable VHL-recruiting PROTAC achieves SMARCA2 degradation in vivo

Nature Communications, 2022
Protein degraders are an emerging drug modality; however, their properties lie beyond typical drug-like space. Here the authors report optimisation via structure-based exit vector and linker design towards the VHL-recruiting PROTAC ACBI2, an orally ...
Christiane Kofink, Nicole Trainor, Barbara Mair, Simon Wöhrle, Melanie Wurm, Nikolai Mischerikow, Michael J. Roy, Gerd Bader, Peter Greb, Géraldine Garavel, Emelyne Diers, Ross McLennan, Claire Whitworth, Vesna Vetma, Klaus Rumpel, Maximilian Scharnweber, Julian E. Fuchs, Thomas Gerstberger, Yunhai Cui, Gabriela Gremel, Paolo Chetta, Stefan Hopf, Nicole Budano, Joerg Rinnenthal, Gerhard Gmaschitz, Moriz Mayer, Manfred Koegl, Alessio Ciulli, Harald Weinstabl, William Farnaby   +29 more
doaj   +1 more source