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Autophagy and Skin Diseases [PDF]
Autophagy is a highly conserved lysosomal degradation system that involves the creation of autophagosomes, which eventually fuse with lysosomes and breakdown misfolded proteins and damaged organelles with their enzymes. Autophagy is widely known for its function in cellular homeostasis under physiological and pathological settings. Defects in autophagy
Kim Klapan+9 more
openaire +6 more sources
Successful treatment of disseminated granuloma annulare with adalimumab [PDF]
Granuloma annulare (GA) is a chronic inflammatory necrobiotic granulomatous skin disease, which is based on a delayed hypersensitivity reaction caused by the production of interferon- (IFN-) by tissue macrophages and th1-limocytes, tumor necrosis factor-
Denis V. Zaslavsky+6 more
doaj +1 more source
The article discusses the common pathogenetic pathways of autoimmune skin diseases – psoriasis and vitiligo. Currently proposed treatments for vitiligo do not significantly reduce or completely restore skin pigmentation. The use of adalimumab for 6 years
N. S. Rudneva+3 more
doaj +1 more source
Challenges documenting racial disparities in Merkel cell carcinoma
Merkel cell carcinoma (MCC) is a rare, aggressive neuroendocrine skin cancer that predominantly impacts White patients. Overall incidence and the proportion of minority patients with MCC are both rising.
Mackenzie R. Martin+4 more
doaj +1 more source
Eosinophils in skin diseases [PDF]
AbstractEosinophil infiltration is a common finding in a broad spectrum of skin diseases, despite the fact that the skin is devoid of eosinophils under physiologic conditions. Although cutaneous eosinophilia is reactive, cytokine-mediated in most cases, diseases with an intrinsic mutation-mediated clonal expansion of eosinophils can also manifest on ...
Hans-Uwe Simon+5 more
openaire +3 more sources
Introduction Evidence indicates that physicians’ smoking cessation advice is significant for tobacco control, which is an impetus to encourage smoking cessation among smokers, but the estimated influence of physicians’ smoking cessation advice on smokers’
Xiangjin Gao*+6 more
doaj +1 more source
Classification of Skin Disease Using Transfer Learning in Convolutional Neural Networks [PDF]
Automatic classification of skin disease plays an important role in healthcare especially in dermatology. Dermatologists can determine different skin diseases with the help of an android device and with the use of Artificial Intelligence. Deep learning requires a lot of time to train due to the number of sequential layers and input data involved ...
arxiv +1 more source
IntroductionThe anti-programmed cell death protein 1 (PD-1) antibody cemiplimab has shown promising results in the treatment of unresectable or metastatic squamous cell carcinoma, however, frequently leads to immune-related adverse events limiting ...
Simon Fietz+8 more
doaj +1 more source