Results 1 to 10 of about 69,322 (198)

Generation of αGal-enhanced bifunctional tumor vaccine

Acta Pharmaceutica Sinica B, 2022
Hepatocellular carcinoma (HCC) is a common malignant tumor with poor prognosis and high mortality. In this study, we demonstrated a novel vaccine targeting HCC and tumor neovascular endothelial cells by fusing recombinant MHCC97H cells expressing porcine
Jian He, Yu Huo, Zhikun Zhang, Yiqun Luo, Xiuli Liu, Qiaoying Chen, Pan Wu, Wei Shi, Tao Wu, Chao Tang, Huixue Wang, Lan Li, Xiyu Liu, Yong Huang, Yongxiang Zhao, Lu Gan, Bing Wang, Liping Zhong   +17 more
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Generation of in situ CRISPR-mediated primary and metastatic cancer from monkey liver

Signal Transduction and Targeted Therapy, 2021
Non-human primates (NHPs) represent the most valuable animals for drug discovery. However, the current main challenge remains that the NHP has not yet been used to develop an efficient translational medicine platform simulating human diseases, such as ...
Liping Zhong, Yong Huang, Jian He, Nuo Yang, Banghao Xu, Yun Ma, Junjie Liu, Chao Tang, Chengpiao Luo, Pan Wu, Zongqiang Lai, Yu Huo, Tao Lu, Dongni Huang, Wenlin Gong, Lu Gan, Yiqun Luo, Zhikun Zhang, Xiyu Liu, Yongxiang Zhao   +19 more
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Current Strategies for Tumor Photodynamic Therapy Combined With Immunotherapy

Frontiers in Oncology, 2021
Photodynamic therapy (PDT) is a low invasive antitumor therapy with fewer side effects. On the other hand, immunotherapy also has significant clinical applications in the treatment of cancer.
Jianfeng Hua, Pan Wu, Lu Gan, Zhikun Zhang, Jian He, Liping Zhong, Yongxiang Zhao, Yong Huang, Yong Huang   +8 more
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Loss of histone macroH2A1 in hepatocellular carcinoma cells promotes paracrine-mediated chemoresistance and CD4+CD25+FoxP3+ regulatory T cells activation [PDF]

, 2020
Rationale: Loss of histone macroH2A1 induces appearance of cancer stem cells (CSCs)-like cells in hepatocellular carcinoma (HCC). How CSCs interact with the tumor microenvironment and the adaptive immune system is unclear. Methods: We screened aggressive
Drovakova A., Giallongo S., Li Volti G., Lo Re O., Mazza T., Rappa F., Roskams T., Sanna P., Tsochatzis E., Van Haele M., Vinciguerra M., Vinh Luong T.   +11 more
core   +1 more source

Identification of co-expression hub genes for ferroptosis in kidney renal clear cell carcinoma based on weighted gene co-expression network analysis and The Cancer Genome Atlas clinical data

Scientific Reports, 2022
Renal clear cell carcinoma (KIRC) is one of the most common tumors worldwide and has a high mortality rate. Ferroptosis is a major mechanism of tumor occurrence and development, as well as important for prognosis and treatment of KIRC. Here, we conducted
Shengxian Li, Ximei Xu, Ruirui Zhang, Yong Huang   +3 more
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Theranostic Pretargeting Drug Delivery and Imaging Platforms in Cancer Precision Medicine

Frontiers in Oncology, 2020
Theranostics are nano-size or molecular-level agents serving for both diagnosis and therapy. Structurally, they are drug delivery systems integrated with molecular or targeted imaging agents.
Sudath Hapuarachchige, Dmitri Artemov, Dmitri Artemov   +2 more
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The Tree Shrew as a Model for Cancer Research

Frontiers in Oncology, 2021
Animal disease models are necessary in medical research, and an appropriate animal model is of great importance for studies about the prevention or treatment of cancer.
Tao Lu, Hongmei Peng, Liping Zhong, Pan Wu, Jian He, Zhiming Deng, Yong Huang   +6 more
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Proposal of a population wide genome-based testing for Covid-19

Scientific Reports, 2022
Our lives (and deaths) have by now been dominated for two years by COVID-19, a pandemic that has caused hundreds of millions of disease cases, millions of deaths, trillions in economic costs, and major restrictions on our freedom. Here we suggest a novel
Hans Lehrach, Jon Curtis, Bodo Lange, Lesley A. Ogilvie, Richard Gauss, Christoph Steininger, Erhard Scholz, Matthias Kreck   +7 more
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Development and Prospect of Theranostic Medical Isotopes and Radiopharmaceuticals in China

Xiehe Yixue Zazhi, 2022
Theranostics in nuclear medicine is the combination of radionuclide imaging and internal radiotherapy, so as to realize the visualized diagnosis and precise treatment of diseases.
CHEN Yue
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Single Nano-Sized Metal–Organic Framework for Bio-Nanoarchitectonics with In Vivo Fluorescence Imaging and Chemo-Photodynamic Therapy

Nanomaterials, 2022
Theranostics is an emerging technique for cancer treatments due to its safety and high efficiency. However, the stability, efficiency, and convenience of preparation are the main challenges for developing theranostics.
Yong-Mei Wang, Ying Xu, Xinxin Zhang, Yifan Cui, Qingquan Liang, Cunshun Liu, Xinan Wang, Shuqi Wu, Rusen Yang   +8 more
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