Results 1 to 10 of about 45,139 (271)
Transthyretin Amyloidosis: Chaperone Concentration Changes and Increased Proteolysis in the Pathway to Disease. [PDF]
PLoS ONE, 2015 Transthyretin amyloidosis is a conformational pathology characterized by the extracellular formation of amyloid deposits and the progressive impairment of the peripheral nervous system.
Gonçalo da Costa +10 more
doaj +3 more sources
Indonesian Biomedical Journal, 2022 BACKGROUND: Transthyretin protein experiences misfolding and aggregation in preeclampsia due to placental ischemia and inflammation. Placental endothelial damage occurring in preeclampsia stimulates the production of larger young platelets in the bone ...
Asri Ragil Kemuning +4 more
doaj +1 more source
Utility of Genetic Testing in Patients with Transthyretin Amyloid Cardiomyopathy: A Brief Review
Biomedicines, 2023 Transthyretin amyloid cardiomyopathy (ATTR-CM) is an increasingly diagnosed condition. Although wild-type transthyretin amyloidosis (ATTRwt) is the most common ATTR-CM, hereditary transthyretin amyloidosis (ATTRv) may also occur.
Ana-Maria Merino-Merino +4 more
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Amyloidogenicity assessment of transthyretin gene variants
Annals of Clinical and Translational Neurology, 2022 Objective Hereditary transthyretin‐mediated amyloidosis is a treatable condition caused by amyloidogenic variants in the transthyretin‐gene resulting in severe peripheral neuropathy or cardiomyopathy.
Nicolai B. Grether +11 more
doaj +1 more source
Cardiac Transthyretin Amyloidosis: Hidden in Plain Sight
Case Reports in Medicine, 2021 Amyloidosis is an underappreciated medical condition with symptoms camouflaging as common medical comorbidities leading to its underdiagnosis due to its systemic involvement.
Constantine N. Logothetis +2 more
doaj +1 more source
Biomedicines, 2022 Background: In cardiac amyloidosis, the prevalence of thromboembolic events and atrial fibrillation is higher in transthyretin amyloidosis compared to immunoglobulin light chain amyloidosis.
Mathijs O. Versteylen +3 more
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Decreased transthyretin predicts a poor prognosis in primary myelodysplastic syndrome
Frontiers in Nutrition, 2023 BackgroundThis study aims to investigate the prognostic significance of transthyretin in newly diagnosed myelodysplastic syndromes (MDS).MethodsThe clinical, laboratory, and follow-up data of 280 newly diagnosed patients with MDS were collected.
Ying Chen +29 more
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Hereditary transthyretin amyloidosis
Нервно-мышечные болезни, 2020 Hereditary transthyretin amyloidosis is described in this review, including the TTR gene structure and mutation spectrum, the transthyretin protein structure and functions, the main clinical manifestations of transthyretin amyloidosis.
T. A. Adyan, A. V. Polyakov
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Hereditary cardiac amyloidosis associated with Pro24Ser transthyretin mutation: a case report
Journal of Medical Case Reports, 2018 Background Transthyretin amyloidosis is a systemic disorder caused by extracellular deposition of insoluble amyloid fibrils in peripheral and autonomic nerves, heart, kidney, gastrointestinal tract, and other organs.
Hiroyuki Yamamoto +6 more
doaj +1 more source
Aggregated transthyretin is specifically packaged into placental nano-vesicles in preeclampsia
Scientific Reports, 2017 In preeclampsia, the serum levels of transthyretin, a carrier protein for thyroxine, are elevated. Transthyretin isolated from preeclamptic serum is also aggregated and can induce preeclampsia-like symptoms in pregnant IL10−/− mice.
Mancy Tong +7 more
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