Results 1 to 10 of about 6,608 (237)

One-step stromal vascular fraction therapy in osteoarthritis with tropoelastin-enhanced autologous stromal vascular fraction gel [PDF]

Frontiers in Bioengineering and Biotechnology
Background: Osteoarthritis (OA) is a debilitating degenerative joint disease, leading to significant pain and disability. Despite advancements, current regenerative therapies, such as mesenchymal stem cells (MSCs), face challenges in clinical efficacy ...
Junjun Yang, Junjun Yang, Xin Wang, XueBao Zeng, Rong Wang, Yanming Ma, Zhenlan Fu, Zu Wan, Zhi Wang, Liu Yang, Guangxing Chen, Xiaoyuan Gong   +11 more
doaj   +4 more sources

Tropoelastin Promotes the Formation of Dense, Interconnected Endothelial Networks [PDF]

Biomolecules, 2021
Tropoelastin, the soluble precursor of elastin, has been used for regenerative and wound healing purposes and noted for its ability to accelerate wound repair by enhancing vascularization at the site of implantation.
Aleen Al Halawani, Lea Abdulkhalek, Suzanne M. Mithieux, Anthony S. Weiss   +3 more
doaj   +2 more sources

Stochastic simulations of self-organized elastogenesis in the developing lung. [PDF]

PLoS Computational Biology, 2023
In the normal lung, the dominant cable is an elastic "line element" composed of elastin fibers bound to a protein scaffold. The cable line element maintains alveolar geometry by balancing surface forces within the alveolus and changes in lung volume with
Xiru Fan, Cristian Valenzuela, Weijing Zhao, Zi Chen, Dong Wang, Steven J Mentzer   +5 more
doaj   +2 more sources

Dill Extract Induces Elastic Fiber Neosynthesis and Functional Improvement in the Ascending Aorta of Aged Mice with Reversal of Age-Dependent Cardiac Hypertrophy and Involvement of Lysyl Oxidase-Like-1 [PDF]

Biomolecules, 2020
Elastic fibers (90% elastin, 10% fibrillin-rich microfibrils) are synthesized only in early life and adolescence mainly by the vascular smooth muscle cells through the cross-linking of its soluble precursor, tropoelastin.
Wassim Fhayli, Quentin Boëté, Nadjib Kihal, Valérie Cenizo, Pascal Sommer, Walter A. Boyle, Marie-Paule Jacob, Gilles Faury   +7 more
doaj   +4 more sources

The Matrix Protein Tropoelastin Prolongs Mesenchymal Stromal Cell Vitality and Delays Senescence During Replicative Aging [PDF]

Advanced Science
Cellular senescence leads to the functional decline of regenerative cells such as mesenchymal stromal/stem cells (MSCs), which gives rise to chronic conditions and contributes to poor cell therapy outcomes. Aging tissues are associated with extracellular
Sunny Shinchen Lee, Aleen Al Halawani, Jonathan D. Teo, Anthony S. Weiss, Giselle C. Yeo   +4 more
doaj   +2 more sources

Pathological investigations and correlation research of microfibrillar-associated protein 4 and tropoelastin in oral submucous fibrosis [PDF]

BMC Oral Health, 2021
Background Oral submucous fibrosis (OSF), distinguished by abnormal collagen deposition, is a potentially malignant disorder with 4.2% (95% CI 2.7–5.6%) of malignant transformation and rising global prevalence.
Binjie Liu, Wenqun Gou, Hui Feng
doaj   +4 more sources

Leptospira Immunoglobulin-Like Protein B Interacts with the 20th Exon of Human Tropoelastin Contributing to Leptospiral Adhesion to Human Lung Cells [PDF]

Frontiers in Cellular and Infection Microbiology, 2017
Leptospira immunoglobulin-like protein B (LigB), a surface adhesin, is capable of mediating the attachment of pathogenic leptospira to the host through interaction with various components of the extracellular matrix (ECM).
Ching-Lin Hsieh, Andrew Tseng, Hongxuan He, Chih-Jung Kuo, Xuannian Wang, Xuannian Wang, Yung-Fu Chang   +6 more
doaj   +2 more sources

Subtle balance of tropoelastin molecular shape and flexibility regulates dynamics and hierarchical assembly [PDF]

, 2015
The assembly of the tropoelastin monomer into elastin is vital for conferring elasticity on blood vessels, skin, and lungs. Tropoelastin has dual needs for flexibility and structure in self-assembly.
Baldock, Clair, Buehler, Markus J, Tarakanova, Anna, Weiss, Anthony S., Wise, Steven G., Yeo, Giselle C.   +5 more
core   +3 more sources

Tropoelastin Improves Post-Infarct Cardiac Function. [PDF]

Circ Res, 2023
BACKGROUND: Myocardial infarction (MI) is among the leading causes of death worldwide. Following MI, necrotic cardiomyocytes are replaced by a stiff collagen-rich scar.
Hume RD, Kanagalingam S, Deshmukh T, Chen S, Mithieux SM, Rashid FN, Roohani I, Lu J, Doan T, Graham D, Clayton ZE, Slaughter E, Kizana E, Stempien-Otero AS, Brown P, Thomas L, Weiss AS, Chong JJH.   +17 more
europepmc   +2 more sources

Microfibril-associated glycoprotein 4 forms octamers that mediate interactions with elastogenic proteins and cells [PDF]

Nature Communications
Microfibril-associated glycoprotein 4 (MFAP4) is a 36-kDa extracellular matrix glycoprotein with critical roles in organ fibrosis, chronic obstructive pulmonary disease, and cardiovascular disorders, including aortic aneurysms.
Michael R. Wozny, Valentin Nelea, Iram Fatima S. Siddiqui, Shaynah Wanga, Vivian de Waard, Mike Strauss, Dieter P. Reinhardt   +6 more
doaj   +2 more sources