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Tropoelastin and Elastin Assembly [PDF]

Frontiers in Bioengineering and Biotechnology, 2021
Elastic fibers are an important component of the extracellular matrix, providing stretch, resilience, and cell interactivity to a broad range of elastic tissues.
Jazmin Ozsvar, Jazmin Ozsvar, Chengeng Yang, Stuart A. Cain, Clair Baldock, Anna Tarakanova, Anna Tarakanova, Anthony S. Weiss, Anthony S. Weiss, Anthony S. Weiss   +9 more
doaj   +5 more sources

The Matrix Protein Tropoelastin Prolongs Mesenchymal Stromal Cell Vitality and Delays Senescence During Replicative Aging [PDF]

Advanced Science
Cellular senescence leads to the functional decline of regenerative cells such as mesenchymal stromal/stem cells (MSCs), which gives rise to chronic conditions and contributes to poor cell therapy outcomes. Aging tissues are associated with extracellular
Sunny Shinchen Lee, Aleen Al Halawani, Jonathan D. Teo, Anthony S. Weiss, Giselle C. Yeo   +4 more
doaj   +4 more sources

Evolutionary constraints on positional sequence, collective properties and sequence style of tropoelastin dictated by fundamental requirements for formation and function of the extracellular elastic matrix [PDF]

Matrix Biology Plus
Elastin is the extracellular matrix protein responsible for properties of extension and energy-efficient elastic recoil in large blood vessels, lung parenchyma and other vertebrate tissues.
Fred W. Keeley
doaj   +4 more sources

Tropoelastin Promotes the Formation of Dense, Interconnected Endothelial Networks [PDF]

Biomolecules, 2021
Tropoelastin, the soluble precursor of elastin, has been used for regenerative and wound healing purposes and noted for its ability to accelerate wound repair by enhancing vascularization at the site of implantation.
Aleen Al Halawani, Lea Abdulkhalek, Suzanne M. Mithieux, Anthony S. Weiss   +3 more
doaj   +2 more sources

Dill Extract Induces Elastic Fiber Neosynthesis and Functional Improvement in the Ascending Aorta of Aged Mice with Reversal of Age-Dependent Cardiac Hypertrophy and Involvement of Lysyl Oxidase-Like-1 [PDF]

Biomolecules, 2020
Elastic fibers (90% elastin, 10% fibrillin-rich microfibrils) are synthesized only in early life and adolescence mainly by the vascular smooth muscle cells through the cross-linking of its soluble precursor, tropoelastin.
Wassim Fhayli, Quentin Boëté, Nadjib Kihal, Valérie Cenizo, Pascal Sommer, Walter A. Boyle, Marie-Paule Jacob, Gilles Faury   +7 more
doaj   +4 more sources

Subtle balance of tropoelastin molecular shape and flexibility regulates dynamics and hierarchical assembly [PDF]

, 2015
The assembly of the tropoelastin monomer into elastin is vital for conferring elasticity on blood vessels, skin, and lungs. Tropoelastin has dual needs for flexibility and structure in self-assembly.
Baldock, Clair, Buehler, Markus J, Tarakanova, Anna, Weiss, Anthony S., Wise, Steven G., Yeo, Giselle C.   +5 more
core   +3 more sources

Stochastic simulations of self-organized elastogenesis in the developing lung. [PDF]

PLoS Computational Biology, 2023
In the normal lung, the dominant cable is an elastic "line element" composed of elastin fibers bound to a protein scaffold. The cable line element maintains alveolar geometry by balancing surface forces within the alveolus and changes in lung volume with
Xiru Fan, Cristian Valenzuela, Weijing Zhao, Zi Chen, Dong Wang, Steven J Mentzer   +5 more
doaj   +2 more sources

Characterization of Microfibrillar-associated Protein 4 (MFAP4) as a Tropoelastin- and Fibrillin-binding Protein Involved in Elastic Fiber Formation [PDF]

, 2015
MFAP4 (microfibrillar-associated protein 4) is an extracellular glycoprotein found in elastic fibers without a clearly defined role in elastic fiber assembly.
Heumüller, Stefanie E, Holm, Anne T, Holmskov, Uffe, Moeller, Jesper B, Moestrup, Soren K, Pilecki, Bartosz, Schlosser, Anders, Sengle, Gerhard, Sorensen, Grith L, Wallis, Russell, Wohl, Alexander P, Zuk, Alexandra V   +11 more
core   +3 more sources

Decreased expression of cytokeratin 15 and tropoelastin in men with androgenetic alopecia and its relationship with increased expression of p15/p16 [PDF]

Archives of Medical Science, 2020
Introduction Androgenetic alopecia (AGA) or male pattern baldness is a polygenic disease with a high prevalence in the Caucasian population, with psychosocial implications. However, the molecular mechanisms involved are unknown. The aim of this study was
Miguel A. Ortega, María J. Álvarez-Rocha, Ángel Asúnsolo, Beatriz Romero, Santiago Coca, Melchor Álvarez-Mon, Julia Buján, Natalio García-Honduvilla   +7 more
doaj   +2 more sources

Isoform-specific oxidative modifications of tropoelastin by HOCl and MPO alter protein self-assembly [PDF]

Redox Report
Background Tropoelastin (TE), the soluble precursor of elastin, is critical for the elasticity of arteries, lungs, and skin. Oxidative damage to TE has been implicated in vascular diseases, but the isoform-specific effects remain poorly understood ...
Karoline Lindgaard Mikkelsen, Tina Nybo, Michael J. Davies, Adelina Rogowska-Wrzesinska   +3 more
doaj   +2 more sources