Results 151 to 160 of about 212,427 (218)

GM‐CSF Promotes Neutrophil PD‐L1 Expression Through the VEGFR‐2/STAT6/CSF2 Signaling Axis in Oral Squamous Cell Carcinoma

Advanced Science, EarlyView.
VEGFR‐2 signaling in OSCC activates Src–STAT6‐dependent CSF2 transcription, driving tumor‐derived GM‐CSF secretion. GM‐CSF programs neutrophils to express PD‐L1 through STAT5–mTOR/S6K signaling, suppressing cytotoxic CD8+ T cells. This pathway reveals a tumor–neutrophil immune checkpoint circuit that limits anti‐PD‐1 responsiveness in OSCC.
Fangxing Zhu, Yuanhe You, Yiyi Zhang, Yibin Dai, Xinyu Zhou, Yong Fu, Xi Lu, Yingying Huang, Zhihang Zhou, Ronghui Xia, Wutong Ju, Zhaoqi Yuan, Laiping Zhong, Tongchao Zhao   +13 more
wiley   +1 more source

Rapid Detection of Hypervirulent Klebsiella pneumoniae by Multiplex PCR and Nucleic Acid Chromatography: Evaluation of Diagnostic Performance and Clinical Utility. [PDF]

Cureus
Tokano M, Tarumoto N.
europepmc   +1 more source

PARP Inhibitors plus Anlotinib as Bridging Therapy for Armored CAR‐T Cells in Ovarian Cancer Enhances Infiltration and Antitumor Efficacy

Advanced Science, EarlyView.
This study shows that a PARP inhibitor combined with anlotinib, administered as bridging therapy, preconditions the tumor microenvironment to enhance the infiltration and antitumor activity of subsequently infused CAR‐T cells across preclinical ovarian cancer models, supporting bridging therapy as a promising strategy to address limited CAR‐T cell ...
Huayi Li, Minghua Xiang, Qiuyang Xu, Jiahao Liu, Xiaofei Jiao, Wei Mu, Xiaoying Lv, Kangjia Tao, Yu Xu, Dongchen Zhou, Wenjian Gong, Danmei Yan, Yixin Hu, Sen Xu, Bingbing Zhao, Jundong Li, Yongkang Gai, Guang Hu, Li Zhu, Qinglei Gao, Yong Fang   +20 more
wiley   +1 more source

Bioadhesive‐Integrated 3D‐Printed Multilayer Scaffolds Secure a Mechanically‐Stable Osteoimmune Niche for Enhanced Bone Augmentation

Advanced Science, EarlyView.
A 3D‑printed multilayer adhesive scaffold, firmly anchored to bone defects by simple finger pressing, suppresses micromotion and secures mechanical stability of the osteogenic niche. This stabilization likely contributes to the enhanced bone augmentation by fostering a pro‑regenerative mechano‐immune profile—characterized by M2‑like macrophage ...
Delu Zhao, Qiuyi Li, Lingyun Wang, Chongao Zhang, Yutian Cheng, Shuang Liu, Fulan Wei, Zheqin Dong   +7 more
wiley   +1 more source

A Customizable Tyramide Signal Amplification-Based Multiplex Immunofluorescence Protocol for FFPE Tissues. [PDF]

Curr Issues Mol Biol
Sheng W, Mohiuddin TM, Zhang C, Al-Rawe M, Konrad L, Wagner S, Zeppernick F, Meinhold-Heerlein I, Hussain AF.   +8 more
europepmc   +1 more source

Structure-function multilayer network integration and cognition in multiple sclerosis. [PDF]

Netw Neurosci
Breedt LC, Pontillo G, Santos FAN, Vriend C, Prados F, Wink AM, Bisecco A, Cagol A, Calabrese M, Castellaro M, Collorone S, Cortese R, De Stefano N, Enzinger C, Filippi M, Foster MA, Gallo A, Gonzalez-Escamilla G, Granziera C, Groppa S, Høgestøl EA, Llufriu S, Martinez-Heras E, Solana E, Messina S, Moccia M, Nygaard GO, Palace J, Pinter D, Rocca MA, Toosy A, Valsasina P, Ciccarelli O, Strijbis EM, Barkhof F, Schoonheim MM, Douw L, MAGNIMS study group.   +37 more
europepmc   +1 more source

Multiplex fluorescent PCR-based detection of Helicobacter pylori nucleic acid and antibiotic resistance genes in clinical stool samples: a performance evaluation from Gansu Province, China. [PDF]

BMC Infect Dis
Dong Y, Yang J, Xie B, Wang Y, Chen X, Zhang D.   +5 more
europepmc   +1 more source

Detection of Certain Berries in Difficult Samples by Singleplex and Multiplex Real-Time PCR-HRM: A Case Study of Pitfalls. [PDF]

Methods Protoc
Fialova L, Marova I.
europepmc   +1 more source

Development of rapid multiplex human herpesvirus detection systems based on recombinase polymerase amplification and a lateral flow assay. [PDF]

Front Cell Dev Biol
Sun Y, Ling S, Tang D, Zu H, Yang M, Shen C.   +5 more
europepmc   +1 more source