Results 61 to 70 of about 62,984 (216)

PRMT1‐Mediated LDHA Methylation Drives STAT3 Lactylation to Orchestrate Intestinal Inflammation and Tumorigenesis

Advanced Science, EarlyView.
This study identifies an immunometabolic axis wherein SAM‐driven PRMT1 methylates LDHA, enhancing its activity. The resultant lactate induces STAT3 K709 lactylation, which stabilizes an active conformation to promote STAT3 phosphorylation and IL‐10 expression.
Hui Wang, Mengyu Zhang, Weipeng Gong, Jiaxuan Wu, Junping Zhang, Wenxiu Zhang, Yue Liu, Kui Wang, Canhua Huang, Jun Zhou, Sijin Wu, Yan Li, Tianliang Li   +12 more
wiley   +1 more source

Multiplex-Ready PCR: A new method for multiplexed SSR and SNP genotyping-3

, 2011
-003, (B) UDP96-008, (C) BPPCT028, (D) BPPCT014, (E) pchgms21.2 and (F) pchgms17 with 50, 50, 40, 40, 70 and 50 nM of locus-specific primer, respectively; and for panel 2 using SSR markers (G) UDP96-010, (H) BPPCT039, (I) BPPCT004, (J) pchcms04, (K ...
Matthew J Hayden (44210), Kenneth J Chalmers (44213), Thao M Nguyen (44211), Amanda Waterman (44212)   +3 more
core   +1 more source

ZDHHC9‐Mediated Palmitoylation of ACSL4 Drives Ferroptosis in Diabetes Mellitus–Induced Erectile Dysfunction

Advanced Science, EarlyView.
ABSTRACT Diabetes mellitus‐induced erectile dysfunction (DMED) is a highly prevalent complication among diabetic patients; however, its underlying pathogenic mechanisms remain incompletely understood. Metabolic disorder is a hallmark of diabetes, yet its precise contribution to DMED progression is not well defined.
Wanyang Guo, Ming Xiao, Mengjun Huang, Dongzi Peng, Ruijiang Zeng, Ruilin Liu, Yuanqiao Zhao, Zhihan Ouyang, Yulong Hong, Zexian Ding, Zhuo Xing, Hao Su, Jinxiang Wang, Wenjun Mao, Xin Jin   +14 more
wiley   +1 more source

Myeloma Multiplex gondozása során felmerülő kérdések és problémák a betegek szemszögéből

, 2020
Myeloma multiplex gondozása során felmerülő kérdések és problémák a betegek szemszögéből. Debreceni Egyetem Klinikai Központ Belgyógyászat B épület Haematológiai Tanszék.vtvtápolás és betegellátás – ápolólevelezőmagyarBSc ...
Baloghné Morvai, Vivien
core  

Activation of ERBB4 Pathway Inhibits Pathological Transdifferentiation of Lung Epithelial Progenitors into CD66c+ Basal Cells in Severe Lung Injury

Advanced Science, EarlyView.
In fibrotic distal lung regions, CD66c+ basal cells emerge as a pathological state. Using human distal lung organoids, this study identifies CD66c+ basal cells as a pro‐fibrotic state arising through transdifferentiation from secretory, AT2, and basal cells.
Kaijun Lin, Xinran Deng, Haonan Wang, Yamei Jiang, Jian Sun, Hailin Ding, Ming Ye, Xiaoting Wang, Yu Wang, Li Yuan, Zhenju Song, Xinhua Lin, Shenfei Sun, Ning Jiang   +13 more
wiley   +1 more source

Steatocystoma multiplex

Dermatology Online Journal, 2003
A 25-year-old man with a 20-year history of asymptomatic nodules on his arms and trunk, which histopathological analysis showed to be consistent with steatocystoma multiplex, is presented. Steatocystoma multiplex is a disorder characterized by multiple, asymptomatic, dermal cysts that usually occur on the trunk and proximal aspects of the extremities ...
openaire   +4 more sources

O‐GlcNAcylated TAP1 Impairs Antigen Presentation and Promotes Immune Evasion in Bladder Cancer

Advanced Science, EarlyView.
This article unveils a critical mechanism of immune evasion in bladder cancer, which the O‐GlcNAc modification of TAP1 disrupts antigen presentation. This modification triggers HLA‐A degradation, shielding tumor cells from CD8+ T cell attack. The findings highlight targeting this pathway as a promising therapeutic avenue to sensitize tumors to ...
Jinpeng Wu, Xueting Ren, Zhen Zhai, Lu Wang, Liang Liang, Zengqi Tan, Jiazhen Zhao, Yuxuan Han, Yuhan Li, Feng Guan, Xiang Li   +10 more
wiley   +1 more source

Random Multiplexing

IEEE Transactions on Information Theory
This paper has been accepted for publication in IEEE Transactions on Information ...
Lei Liu 0005, Yuhao Chi, Shunqi Huang, Zhaoyang Zhang 0001   +3 more
openaire   +2 more sources

A sclerosis multiplex korszerű terápiás lehetőségei

, 2019
A diplomamunkám megírása során törekedtem arra, hogy egy átfogó képet adjak a sclerosis multiplex autoimmun betegség legfontosabb ismérveiről, valamint igyekeztem összefoglalni a terápiás lehetőségeit a már bevált gyógyszerektől egészen a legmodernebb ...
Papp, Teodóra
core  

Sclerosis multiplex betegek izomerejének és mozgástartományának fejlesztése PNF technikával

, 2020
A sclerosis multiplex leggyakrabban a 20 és 40 év közötti nőknél alakul ki. A betegség kihat az egyensúly és koordinációs képességre, az izomerőre és a járásra is, így jelentős mértékben romlik a betegek életminősége.
Balogh, Mariann
core