Results 51 to 60 of about 62,984 (216)

MultiVERSE: a multiplex and multiplex-heterogeneous network embedding approach

open access: yes, 2021
International audienceAbstract Network embedding approaches are gaining momentum to analyse a large variety of networks. Indeed, these approaches have demonstrated their effectiveness in tasks such as community detection, node classification, and link ...
Tichit, Laurent   +4 more
core   +1 more source

Targeting UXS1‐Dependent Glucuronate Detoxification Potentiates Metformin's Anti‐Tumor Efficacy in Lung Adenocarcinoma

open access: yesAdvanced Science, EarlyView.
This study reveals that metformin promotes glucuronic acid metabolism in lung adenocarcinoma by activating UGDH S476 phosphorylation and enhancing the conversion of UDPG to UDPGA based on metabolomics analysis. Through compound virtual screening, it is found that plantainoside targeting UGDH downstream UXS1 leads to UDPGA toxicity accumulation ...
Qihai Sui   +14 more
wiley   +1 more source

Compact spatial multiplexers for mode division multiplexing

open access: yesOptics Express, 2014
Spatial multiplexer (SMUX) for mode division multiplexing (MDM) has evolved from mode-selective excitation, multiple-spot and photonic-lantern based solutions in order to minimize both mode-dependent loss (MDL) and coupler insertion loss (CIL). This paper discusses the implementation of all the three solutions by compact components in a small footprint.
Chen, Haoshuo   +3 more
openaire   +3 more sources

GATA4‐Driven Transcription of HtrA1 Promotes Cellular Senescence in Ménière's Disease and Age‐Related Audio‐Vestibular Dysfunction

open access: yesAdvanced Science, EarlyView.
This study identifies the HDAC6/GATA4/HtrA1 axis as a critical driver of cellular senescence in the inner ear. GATA4 nuclear translocation, facilitated by HDAC6 downregulation, transcriptionally activates HtrA1, promoting hair cell senescence, SASP, and audio‐vestibular dysfunction in models of Ménière's disease and age‐related audio‐vestibular ...
Na Zhang   +16 more
wiley   +1 more source

XANTHOMA MULTIPLEX. [PDF]

open access: yesThe Lancet, 1890
n ...
openaire   +2 more sources

Új terápiás lehetőségek a sclerosis multiplex kezelésében

open access: yes, 2020
Háttér: A sclerosis multiplex az idegrendszer krónikus autoimmun eredetű gyulladásos betegsége, amely demyelinizációval és neurodegenerációval jár.
Sztankovics, Noémi
core  

Effects of temporal correlations in social multiplex networks [PDF]

open access: yes, 2017
Multi-layered networks represent a major advance in the description of natural complex systems, and their study has shed light on new physical phenomena.
Michele Starnini   +8 more
core   +1 more source

Genome‐Wide CRISPR Screen Identifies a microRNA Orchestrating Pleiotropic Resistance to Targeted Therapy and T Cell Immunity in Melanoma

open access: yesAdvanced Science, EarlyView.
A genome‐wide microRNA CRISPR screen identifies miR‐18a as a master regulator of cross‐resistance in melanoma. Loss of miR‐18a activates the AJUBA–YAP/Hippo axis to confer BRAFi resistance and enhances THBS1–CD47 interaction to impair CD8+ T cell immunity. hnRNP A1 is identified as an upstream regulator of miR‐18a processing.
Zhao Wang   +19 more
wiley   +1 more source

To multiplex, or not to multiplex

open access: yes
Conference abstract from AGTA conference, 2024.
openaire   +2 more sources

Characterization of multiple topological scales in multiplex networks through supra-Laplacian eigengaps [PDF]

open access: yes, 2016
Multilayer networks have been the subject of intense research during the past few years, as they represent better the interdependent nature of many real-world systems.
Cozzo, E., Moreno, Y.
core   +1 more source

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