Results 111 to 120 of about 3,486,813 (275)
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
UNH Faculty Abroad Series; Spring 2011 [PDF]
, 2011 Ruth Varner UNH Earth Systems Research Center February 17, 2011 Listening for Climate Change North of the Artic Circle Julie Bryce UNH Department of Earth Sciences March 24, 2011 Snapshots of Carbonated Deep Earth: Geochemical Adventures in Italy ...
Center for International Education
core +2 more sources
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
System for near real-time crustal deformation monitoring [PDF]
, 1979 A system is described for use in detecting earth crustal deformation using an RF interferometer technique for such purposes as earthquake predictive research and eventual operational predictions.
Macdoran, P. F.
core +1 more source
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
A Near-Earth Object Model Calibrated to Earth Impactors
The Astronomical JournalThe population of Earth-impacting meteoroids and their size-dependent orbital elements are key to understanding the origin of meteorites and informing planetary defense efforts. Outstanding questions include the role of collisions in depleting meteoroids
Sophie E. Deam +18 more
doaj +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Impact‐Generated Mixing, Melting and Vaporization of the Early Earth's Crust
Earth and Space ScienceEarth's primary accretion was followed by a protracted flux of interplanetary collisions by leftover planetesimals. The effects of the largest collisions—with bodies possibly exceeding 1,000 km diameter—would have been devastating for terrestrial near ...
S. Marchi +3 more
doaj +1 more source