Results 91 to 100 of about 3,486,813 (275)

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Optimisation of Low-Thrust and Hybrid Earth-Moon Transfers [PDF]

, 2016
This paper presents an optimization procedure to generate fast and low-∆v Earth-Moon transfer trajectories, by exploiting the multi-body dynamics of the Sun-Earth-Moon system.
Ceriotti, Matteo, De Sousa Silva, Priscilla A., Sullo, Nicola, Terra, Maisa O.   +3 more
core  

Fast Rise of "Neptune-Size" Planets ($4-8 R_{\rm Earth}$) from $P\sim10$ to $\sim250$ days -- Statistics of Kepler Planet Candidates Up to $\sim 0.75 {\rm AU}$

, 2013
We infer the period ($P$) and size ($R_p$) distribution of Kepler transiting planet candidates with $R_p\ge 1 R_{\rm Earth}$ and $P < 250$ days hosted by solar-type stars.
Dong, Subo, Zhu, Zhaohuan
core   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Earth Flyby Anomalies

, 2009
In a reference frame fixed to the solar system's center of mass, a satellite's energy will change as it is deflected by a planet. But a number of satellites flying by Earth have also experienced energy changes in the Earth-centered frame -- and that's a ...
Anderson, John D., Nieto, Michael Martin
core   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Mass extinctions and supernova explosions

, 2016
A nearby supernova (SN) explosion could have negatively influenced life on Earth, maybe even been responsible for mass extinctions. Mass extinction poses a significant extinction of numerous species on Earth, as recorded in the paleontologic ...
BC Thomas, BC Thomas, D Breitschwerdt, DC Catling, DM Raup, DM Williams, EA Dorfi, EP Ney, FD Kahn, H Svensmark, H Svensmark, H Svensmark, J Ellis, J Ellis, J VivesiBatlle, K Ammon, K Knie, KD Terry, LW Alvarez, M Parthasarathy, MA Rudermann, N Gehrels, NJ Shaviv, O Martin, OH Schindewolf, PJ Crutzen, PM Dragicevich, RA Rohde, RC Smith, RJ Twitchett, RR Large, SE Thorsett, W Baade   +32 more
core   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Virginia Earth Science Collaborative: Developing Highly Qualified Earth Science Teachers [PDF]

, 2008
A collaborative of seven institutes of higher education and two non-profit organizations developed and implemented five earth science courses totaling eighteen credits that enabled secondary teachers to acquire an add-on earth science endorsement: Geology ...
Cothron, J.
core   +1 more source

A perspective from extinct radionuclides on a Young Stellar Object: The Sun and its accretion disk

, 2011
Meteorites, which are remnants of solar system formation, provide a direct glimpse into the dynamics and evolution of a young stellar object (YSO), namely our Sun.
Christophe Michel-Lévy M, Das JP, Dauphas N, Grimm RE, Hollenbach DJ, Hudson GB, Hutcheon ID, Jacobsen B, Kita NT, Kleine T, MacPherson GJ, Marc Chaussidon, Mostéfaoui S, Nagashima K, Nagashima K, Nicolas Dauphas, Safronov VS, Tang H, Wetherill GW., Wetherill GW., Yin Q-Z   +20 more
core   +1 more source