Results 71 to 80 of about 3,486,813 (275)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Earth vitality: An integrated framework for tracking Earth sustainability
Geography and SustainabilityThe Anthropocene era is characterized by the escalating impact of human activities on the environment, as well as the increasingly complex interactions among various components of the Earth system.
Chuanglin Fang, Zhitao Liu
doaj +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
, 2004 This is a web version of a brochure produced by the American Geological Institute to inform people about the importance of Earth science education in K-12 schooling. Educational levels: General public, High school, Intermediate elementary, Middle school,
Michael Smith
core
Heliospheric modulation of the interstellar dust flow on to Earth
, 2018 Aims. Based on measurements by the Ulysses spacecraft and high-resolution modelling of the motion of interstellar dust (ISD) through the heliosphere we predict the ISD flow in the inner planetary system and on to the Earth.
Grün, Eberhard +5 more
core +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Big Earth Data: a new challenge and opportunity for Digital Earth’s development
International Journal of Digital Earth, 2017 Digital Earth has seen great progress during the last 19 years. When it entered into the era of big data, Digital Earth developed into a new stage, namely one characterized by ‘Big Earth Data’, confronting new challenges and opportunities.
Huadong Guo +5 more
doaj +1 more source
Artificial earth sculpture [PDF]
, 1968 William Newsham Blair (1841-91) was born in Scotland, and trained there as an engineer and surveyor. He emigrated to Dunedin at the end of 1863 and took employment with the Otago Provincial Survey Department at the beginning of the new year.
Blair, W.N.
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