Results 111 to 120 of about 29,162 (288)
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
“Скиты” веселой Елизавет: Русские эрмитажи середины XVIII века
ВивліоѳикаThe article is devoted to the history of the appearance of garden pavilions and Russian palace chambers also known as "hermitages." The tradition of building hermitages as special-purpose premises, adopted in Russia in the early eighteenth century, had ...
Анна Корндорф
doaj +1 more source
Why human connection is the true metric of research success
FEBS Open Bio, EarlyView.Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan +3 more
wiley +1 more source
The Sri Lankan tradition for shelter
, 1987 The tradition is the opinion or belief or custom handed down from ancestors to posterity. The tradition is not static, it is the product of the functional demand adopted with the nature and environment, flavoured with culture and belief. It was developed
De Silva, Nimal
core
FEBS Open Bio, EarlyView.The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong +3 more
wiley +1 more source
FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source
Functional Calculation 0: Numerical Apéritif ABSTRACT
, 2008 This article is the first in a series expounding the joys of functional calculation. Functional calculation does with operations applied to functions and numbers what numerical calculation does with functions applied to numbers.
Neville Holmes
core
Versatile vector tools for efficient protein screening across multiple expression systems
FEBS Open Bio, EarlyView.A unified vector toolkit enables rapid protein expression screening across E. coli, insect, and mammalian cells. A single primer pair amplifies the target gene, which is inserted into any vector via a standardized interface. This streamlined workflow eliminates repeated cloning steps, accelerating the identification of optimal expression conditions for
Zhimin Zhu +5 more
wiley +1 more source
, 2012 This thesis centers on the doctrine of Christ in the theology of Charles Haddon Spurgeon through the lens of Spurgeon’s highly developed metaphor, that of Jesus Christ, the “Prince of pilgrims.” That no scholarly work has thus analyzed or surveyed ...
George, Christian T.
core
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source