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Absorption of naloxone in patients prescribed buprenorphine‐naloxone
The American Journal on AddictionsAbstractBackground and ObjectivesWhen administered as prescribed, the naloxone component of buprenorphine‐naloxone combination medications is putatively considered inert due to reduced naloxone bioavailability via transmucosal. However, there is a growing body of evidence to the contrary.
Ian Michel +5 more
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Science Signaling
A negative allosteric modulator of the μ-opioid receptor enhances the efficacy of naloxone.
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A negative allosteric modulator of the μ-opioid receptor enhances the efficacy of naloxone.
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Masui. The Japanese journal of anesthesiology, 2013
Naloxone hydrochloride is an agent capable of antagonizing respiratory depression and analgesic actions which are inherent to the opioid by competitively acting at opioid receptors. It greatly contributed to basic research on antagonistic action of opioid receptors due to its high affinity to opioid receptors, in particular, micro-receptor.
Daisuke, Setoguchi, Yasuyuki, Kakihana
openaire +1 more source
Naloxone hydrochloride is an agent capable of antagonizing respiratory depression and analgesic actions which are inherent to the opioid by competitively acting at opioid receptors. It greatly contributed to basic research on antagonistic action of opioid receptors due to its high affinity to opioid receptors, in particular, micro-receptor.
Daisuke, Setoguchi, Yasuyuki, Kakihana
openaire +1 more source