Results 61 to 70 of about 52,201 (110)
ABSTRACT Background Neoadjuvant chemoimmunotherapy is being explored in locally advanced head and neck squamous cell carcinoma (HNSCC), yet the spatial patterns of pathologic response and clinical implications remain poorly characterized. Methods A 79‐year‐old female with recurrent left oral tongue SCC (PD‐L122C3 Combined Positive Score 90) who ...
Andreja Radevic +9 more
wiley +1 more source
A modular farnesyltransferase‐based chemoenzymatic platform enables fast, site‐specific labeling of nanobodies for PET imaging of inflammation. CD11b‐targeted PET agents selectively image myeloid‐driven inflammation, while CD45‐targeted PET agents provide sensitive whole‐body immune mapping.
Sneha Venkatachalapathy +7 more
wiley +2 more sources
Atherosclerosis: From Pathogenesis to Therapeutic Interventions
The diagram outlines the core mechanisms driving atherosclerosis, including endothelial dysfunction, inflammatory responses, phenotypic switching of smooth muscle cells, and the gut–vascular axis. It also presents the corresponding therapeutic approaches now under development, such as gene therapies, immunotherapies, and nanotechnology platforms ...
Enge Zhou +9 more
wiley +1 more source
Abstract Background Radiomic features derived from positron emission tomography (PET) are sensitive to count statistics and acquisition protocol variability, thereby limiting quantitative reliability in low‐dose and multi‐center total‐body PET imaging.
Mohammad Saber Azimi +2 more
wiley +1 more source
In a mediastinal tumor accompanied by inflammation and a low‐density area, cytokeratin 19 fragment (CYFRA) was elevated, but it decreased preoperatively. The pathological diagnosis was thymoma with extensive necrosis (possibly Type B). A temporal CYFRA elevation may indicate tumor necrosis. Thymoma with necrosis should be considered in the differential
Yuki Nishioka +7 more
wiley +1 more source
An efficient radiosynthesis of fluorine‐18 labeled gluconic acid ([18F]FGA) was developed using two readily available materials, 2‐deoxy‐2‐[18F]fluoro‐D‐glucose ([18F]FDG) and glucose oxidase. [18F]FGA is highly specific for bacterial gluconate metabolism mediated by gluconate permease (GntP) and gluconate kinase (GntK), with rapid clearance, low off ...
Sang Hee Lee +7 more
wiley +2 more sources
ABSTRACT Standardized uptake value maximum (SUVmax), metabolic tumor volumes (MTV), and total lesion glycolysis (TLG) are metabolic parameters used to quantify tumors detected on fluorine‐18 fluorodeoxyglucose positron emission tomography/computed tomography (18F‐FDG PET/CT).
Jesse Johnson +3 more
wiley +1 more source
We used multimodal PET‐MRI data to study the gray matter glucose metabolism‐microstructural architecture relationship in cognitively impaired brains. Results showed a significant positive correlation between glucose metabolism and NODDI metrics, particularly with the orientation dispersion index (ODI), in two independent datasets.
Antonietta Canna +10 more
wiley +1 more source
ABSTRACT Clinical trials combining radiotherapy (RT) with immune checkpoint blockade (ICB) have shown improved outcomes in only a fraction of patients, and optimal strategies for integrating these modalities remain under intense investigation. With a few exceptions, phase III combination trials have yielded disappointing results.
Xuanwei Zhang +10 more
wiley +1 more source

