Results 31 to 40 of about 26,541 (195)

Hydrogel Phase Transition‐Driven Soft Gating Circumvents Debye Screening for Advanced Biosensing

Advanced Science, EarlyView.
A 3D soft gate utilizes a macroscopic hydrogel phase transition to effectively circumvent Debye screening in high‐salt environments. The intact matrix maximizes transmembrane ion flux via volumetric Donnan enrichment and superhydrophilicity. Target‐triggered network disassembly abolishes these effects, introducing a synergistic physical barrier.
Liu Shi, Zimeng Zhang, Bingheng Li, Yalei Gao, Ruirui Zhang, Zheying Mu, Jian Ni, Bing Bo, Genxi Li   +8 more
wiley   +1 more source

H4K12 Lactylation Regulates NDUFS7 to Drive Microglia Reverse Electron Transport in Spinal Cord Injury

Advanced Science, EarlyView.
Lactate accumulation after SCI promotes H4K12la lactylation, which upregulates NDUFS7, triggering mitochondrial RET and ROS, enforcing pro‐inflammatory microglial polarization. MM@mPTC, a biomimetic nanotherapeutic, degrades LDHA in activated microglia, reducing H4K12la lactylation and blocking RET, thus curbing ROS, fostering a reparative phenotype ...
Chenglong Hong, Zhichen Jiang, Zhouwei Wu, Chenyu Wu, Jiang Liu, Kaijie Guo, Yihui Liang, Shaobo Xu, Yuchen Jin, Yong Xiao, Lei Guo, Hui Xu, Sunren Sheng, Chenggui Wang   +13 more
wiley   +1 more source

An Engineered Supramolecular Pathway for Enhanced Electrochemiluminescence

Advanced Science, EarlyView.
A supramolecular electrochemiluminescent (ECL) system is presented in which cucurbit[7]uril (CB7) is covalently linked to [Ru(bpy)3]2+, forming a recognition‐responsive emitter. Host‒guest preorganization of tri‐n‐propylamine enables intramolecular ECL, boosting intensity by 162% compared to the standard system.
Maria Vittoria Balli, Madhurima Jana, Chiara Capolungo, Patrick Gruhs, Pierre Picchetti, Giovanni Valenti, Frank Biedermann, Luca Prodi   +7 more
wiley   +1 more source

A Dual‐Delivery System Designed to Overcome EV‐Mediated Ferroptosis Resistance for Efficient Solid Tumor Therapy

Advanced Science, EarlyView.
(A) Establishment and characterization of the osteosarcoma‐targeted dual‐delivery nanoplatform mBAP1/siENO1@LNP‐OTP for simultaneous regulation of BAP1 and ENO1 in tumor cells. (B) After intravenous administration, mBAP1/siENO1@LNP‐OTP preferentially accumulates at tumor sites through OTP‐mediated targeting.
Yechao Shen, Zhenguo Cao, Zenan Wang, Liang Chen, Jiahao Zhang, Linjie Zeng, Boren Tan, Hengyuan Li, Jiashan Lai, Jiangchu Lei, Fanglu Chen, Peng Lin, Zhenxuan Shao, Zhan Wang   +13 more
wiley   +1 more source

Near‐Infrared Triggered Rechargeable Singlet Oxygen Battery for Sustained Phototherapy: Fast Charging and Long‐Lasting Discharging

Advanced Science, EarlyView.
A near‐infrared‐triggered rechargeable singlet oxygen battery based on PBDP nanoparticles is developed. Upon 808 nm irradiation for 5 min, the system enables efficient singlet oxygen generation, reversible storage via cycloaddition, and sustained release for up to 1 h after light cessation.
Yuxin Ren, Ling Li, Xinyi Zhang, Meiqi Li, Junqing Wang, Mengpan Zhang, Jian Wang, Yanli Tang   +7 more
wiley   +1 more source

Enzyme‐Linked Cycloaddition Assay (ELCA) for Rapid, Ultra‐Sensitive Monitoring of Secreted Sialoglycoproteins

Advanced Science, EarlyView.
Secreted glycoproteins report on cellular state faster than the cell surface, yet remain hard to measure. The Enzyme‐Linked Cycloaddition Assay (ELCA) combines metabolic azide labeling with click chemistry in an ELISA‐like microplate format, resolving sialylation changes within minutes for 1‐2 EUR per sample.
Jon Lundstrøm, Jingmei Yang, Daniel Bojar   +2 more
wiley   +1 more source

Molecular Preorganization Unlocks Reversible Solid‐State Photoconversion in Dianthrylnaphthalene‐Based Molecular Solar Thermal Systems

Angewandte Chemie, EarlyView.
Three dianthrylnaphthalenes were synthesized and investigated for molecular solar thermal (MOST) energy storage. Naphthyl‐based bridging units preorganize the two anthracene moieties face‐to‐face, leading to improved photoisomerization quantum yield (QY) and unlocked bidirectional photoswitching in the solid state compared to previously reported ortho ...
Nicolò Baggi, Lidiya M. Muhammad, Helen Hölzel, Liang Fei, Rebecca J. Salthouse, Mariusz Kubus, Sarah Plutzar, Magnus B. Johansen, Kurt V. Mikkelsen, Kasper S. Pedersen, Kasper Moth‐Poulsen   +10 more
wiley   +2 more sources

Lewis Acid‐Catalyzed Strain‐Enabled (3+3) Annulation of Bicyclo[1.1.0]Butanes With Indolylalcohols: Synthesis of Indole‐Fused Aza‐Bicyclo[3.1.1]Heptanes

Advanced Science, EarlyView.
Bicyclo[1.1.0]butanes undergo a Lewis acid‐catalyzed formal (3 + 3) annulation with indolyl alcohols to furnish indole‐fused aza‐bicyclo[3.1.1]heptanes. Strain‐release‐driven C‐C bond formation, followed by C‐N bond formation via ring expansion, enables the rapid assembly of rigid, sp3‐rich bicyclic architectures under mild reaction conditions ...
Mainak Dey, Tuhin Subhra Das Mahapatra, Pragya Sharma, Manoj V. Mane, Chinmoy Kumar Hazra   +4 more
wiley   +1 more source

Beyond Formate Trapping: A Mechanistic Framework for Homogeneous CO2‐to‐Methanol Conversion With First‐Row Transition Metals

Angewandte Chemie, EarlyView.
This review shows that converting CO2 into methanol with catalysts based on abundant first‐row metals requires more than overcoming formate formation. Success depends on balancing hydrogen activation, intermediate reactivity, product release, and catalyst stability.
Elise Boudry, Christophe M. Thomas
wiley   +2 more sources

Photochemical Regiodivergent Functionalization of Quinolines with Aryl Ketones

Advanced Science, EarlyView.
A photocatalytic system‐controlled approach enables regiodivergent C2‐ and C4‐functionalization of quinolines with aryl ketones by optimizing aryl thiol photocatalysts and formate reductants. Using ortho‐(isopropoxycarbonyl)thiophenol with excess formate facilitates C4‐dearomatization, yielding bridged 1,3‐oxazepanes. In contrast, meta‐(methoxycarbonyl)
Yi‐Lin Zhao, Bei‐Bei Zhang, Xueying Guo, Kui Dong, Zhi‐Xiang Wang, Li‐Zhu Wu, Qiang Liu   +6 more
wiley   +1 more source