Results 11 to 20 of about 4,006 (88)

A Cholesterol Analogue for Cell‐Surface Enzyme Display

Angewandte Chemie, Volume 138, Issue 34, 17 August 2026.
We report a non‐genetic strategy for bacterial cell surface enzyme immobilisation using cholesterol‐based artificial lipids containing Ni2+‐NTA binding groups that can integrate into biological membranes. The engineered cells can capture His‐tagged enzymes directly from cell lysates while preserving intracellular and surface activity, allowing for ...
Vasco F. Batista, Nele Van Wyngaerden, Changzhu Wu, Frank Glorius   +3 more
wiley   +2 more sources

Viral Dynamic Model‐Informed Dose Selection of Mosnodenvir Prophylaxis against DENV‐3 in a Controlled Human Infection Model

Clinical Pharmacology &Therapeutics, EarlyView.
Dengue virus (DENV) infection is a significant global health threat. Mosnodenvir (JNJ‐64281802) is a pan‐serotype small molecule antiviral blocking DENV replication. A Phase IIa study (NCT05048875) evaluated the antiviral activity, safety, and pharmacokinetics of mosnodenvir as prophylaxis against DENV‐3 in a controlled human infection model (CHIM).
Nele Goeyvaerts, Xavier Woot de Trixhe, Martine Neyens, Thomas N. Kakuda, Liesbeth Van Wesenbeeck, Annemie Buelens, Freya Rasschaert, Anna Durbin, Oliver Ackaert   +8 more
wiley   +1 more source

Impact of ultraviolet radiation‐induced damage to hair fiber integrity: A multi‐technique physicochemical characterization of surface and cortex properties

International Journal of Cosmetic Science, EarlyView.
UV exposure induces cuticular and cortical damage in natural hair, with oxidative effects and protein degradation comparable to bleaching. However, double bleaching leads to significantly greater structural degradation, emphasizing distinct mechanisms and severity of chemical versus UV‐induced damage. Abstract The combination of chemist techniques is a
Nathana Cindy Barros Silva Ramos, Alzira Xavier Pinto Dini, Viviane Cristina Albarici, Mayara Miranda Ferreira, Caroline Vieira Hercolino, Adriano da Silva Pinheiro, André Rolim Baby, Maria Valéria Robles Velasco   +7 more
wiley   +1 more source

Exploring the Anticancer Activity of Ruthenium(II)–Arene and Copper(I) Complexes Bearing N‐Heterocyclic Carbene Ligands Containing Azido, Pyridinium, and Ethisterone‐Derived Triazole Groups

European Journal of Inorganic Chemistry, Volume 29, Issue 24, 21 August 2026.
A versatile library of backbone‐functionalized N‐heterocyclic carbene (NHC) ligands was developed and efficiently converted into Cu(I) and Ru(II) NHC complexes, demonstrating that ligand functionalization strongly modulates anticancer activity, with Cu(I)–NHC species showing potent and selective antiproliferative effects against ovarian and breast ...
Alessia Schiavo, Chiara Tupini, Nicola Demitri, Ilaria Lampronti, Thomas Scattolin   +4 more
wiley   +1 more source

Solvent‐Free Fabrication of Eco‐Friendly pH‐Sensitive Smart Films From Poly(Butylene Succinate) and Red Cabbage Anthocyanin for Tracking of Chicken Breast Spoilage

Polymer Engineering &Science, Volume 66, Issue 8, Page 5582-5595, August 2026.
Smart label design. ABSTRACT The growing interest to ensure food safety requires the development of smart indicator systems that are capable of real‐time tracking of spoilage, particularly for perishable foods. Therefore, the purpose of this work is to fabricate eco‐friendly, industrially viable pH‐sensitive smart films via solvent‐free melt ...
Bedriye Ucpinar
wiley   +1 more source

Strong Nonradiative Recombination Induced by Pronounced Lone‐Pair Electron Expression Following Deprotonation in Aziridinium Lead Iodide Perovskites

ENERGY &ENVIRONMENTAL MATERIALS, Volume 9, Issue 4, July 2026.
The transition from linear to cyclic organic cations promotes deprotonation and activates VH(N) defects with pronounced lone‐pair electron activity, thereby inducing severe local distortions and highly efficient nonradiative recombination centers. This work unveils a direct structure–defect–performance correlation and proposes design strategies for the
Qingshan Bao, Linyu Bai, Honghe Zhao, Yanting Qin, Xian Zhao, Yanlu Li   +5 more
wiley   +1 more source

Cholesterol and Cholesterol‐Derived Molecules Differentially Modulate Neuronal Kv7.2/7.3 Channels

Archiv der Pharmazie, Volume 359, Issue 6, June 2026.
Cholesterol, steroid hormones, and cholesterol‐based imidazolium salts (CHIMs) inhibit Kv7.2/Kv7.3 channels. Notably, NBD‐tagged CHIM‐L enhances currents. These findings demonstrate that both chemical modifications and linker length differentially modulate Kv7 activity, revealing variant‐specific sensitivities and potential pharmacological targets for ...
Elif Karabatak, Ronewa Nematswerani, Vivian Meiritz, Nicole Rychlik, Guiscard Seebohm, Frank Glorius, Thomas Budde   +6 more
wiley   +1 more source

Advances in Rapid Nucleic Acid Diagnostics for Hepatitis B and C Viruses: A Comprehensive Review

Reviews in Medical Virology, Volume 36, Issue 2, March 2026.
ABSTRACT Chronic viral hepatitis, predominantly caused by HBV and HCV infections, remains a major global health burden and a leading cause of cirrhosis, hepatocellular carcinoma (HCC), and liver‐related mortality. Achieving the World Health Organisation (WHO) target of diagnosing 90% of HBV and HCV infections by 2030 necessitates a fundamental ...
Hsin‐Ying Ho, Chia‐Yen Dai, I‐Jung Feng, Yen‐Hsu Chen, Ming‐Lung Yu, Che‐Hsin Lin, Ling‐Shan Yu   +6 more
wiley   +1 more source

Summer legumes following winter wheat boost soil nitrogen availability and corn yield

Agronomy Journal, Volume 118, Issue 1, January/February 2026.
Abstract Efficient nitrogen (N) management is critical for improving nitrogen use efficiency (NUE) and sustaining corn (Zea mays L.) yields. We evaluated summer cover crops planted after winter wheat (Triticum aestivum L.) to quantify biomass, N content, soil N dynamics, and subsequent corn performance under rainfed conditions in eastern Nebraska ...
Madhusudhan Adhikari, Paul J. Jasa, Girma Birru, Javed Iqbal   +3 more
wiley   +1 more source

Copper‐Catalyzed Intramolecular Hydrophosphorylation of Alkynes: Straightforward Regio‐ and Stereoselective Access to Six‐Membered Phosphorus Heterocycles

European Journal of Organic Chemistry, Volume 28, Issue 48, December 22, 2025.
Ready access to six‐membered phosphorus heterocycles through copper‐catalyzed intramolecular hydrophosphorylation of ortho‐alkynyl secondary phosphine oxides is described. The reaction proceedes with high regio‐ and stereoselectivity. An atom‐economic copper‐catalyzed intramolecular hydrophosphorylation of ortho‐alkynyl secondary phosphine oxides ...
Hamdi Sanaa, Soufiane Touil, Ali Samarat, Muriel Durandetti   +3 more
wiley   +1 more source