Results 1 to 10 of about 143 (109)

Preface

, 2021
The International Conference on Ocean and Earth Science (ICOES) was held in Jakarta, Indonesia, on 18-20 November 2020 as a part of Indonesian Science Expo (ISE), a scientific event held annually by the Indonesian Institute of Sciences (LIPI). Indonesian

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The Impact of the Central Carbon Energy Metabolism Transcriptome in the Pathogenesis and Outcomes of Multiple Myeloma

Blood, 2021
Introduction: Multiple gene expression profile assays have successfully prognosticated the overall survival (OS) outcomes of patients with Newly Diagnosed Multiple Myeloma (NDMM) and are now available for use in clinical practice. The genes included in
Laura A. Evans, Shaji K. Kumar, Erik Jessen, A. Dispenzieri, P. Kapoor, F. Buadi, D. Dingli, M. Lacy, S. Hayman, N. Leung, Eli Muchtar, R. Warsame, T. Kourelis, S. Russell, Yi Lin, M. Siddiqui, Jin Sung Jang, R. Kyle, S. Rajkumar, M. Gertz, R. Fonseca, W. Gonsalves   +21 more
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Pharmacodynamic Analysis of CAR-T Cell Persistence in Patients with Hematologic Malignancies Treated with NKTR-255, an IL-15 Receptor Agonist That Enhances CD8 + T-Cells: Preliminary Results from a Phase 1 Study

Blood, 2021
Background: Autologous T cells engineered to express a CD19 or BCMA-specific chimeric antigen receptor (CAR) have shown high overall response rates in treatment-refractory B-cell non-Hodgkin lymphoma (NHL) and BCMA + multiple myeloma (MM), respectively.
C. Turtle, E. Budde, K. Patel, M. Perales, A. Cowan, H. Saeed, J. Chavez, A. Hirayama, D. Kirchmeier, Murali Janakiram, Kai Wu, L. Fong, Z. Lee, N. Dixit, Xiaoli Wang, K. Kai, M. Marcondes, J. Zalevsky, N. Shah   +18 more
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Safety, Tolerability, PK/PD and Preliminary Efficacy of NKTR-255, a Novel IL-15 Receptor Agonist, in Patients with Relapsed/Refractory Hematologic Malignancies

Blood, 2021
Introduction: NKTR-255, an investigational novel polymer-conjugated recombinant human interleukin (IL)-15 agonist, maintains the full spectrum of IL-15 biology and provides sustained pharmacodynamic (PD) responses without the need for daily dosing ...
N. Shah, A. Tan, E. Budde, C. Hofmeister, A. Cowan, M. Perales, T. Choi, H. Saeed, J. Chavez, J. Ye, M. Cairo, D. Rizzieri, G. Orloff, Z. Lee, N. Dixit, Wildaliz Nieves, Qiang Zhao, Xiaoli Wang, K. Kai, M. Marcondes, M. Tagliaferri, J. Zalevsky, K. Patel   +22 more
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Quality-Adjusted Time without Symptoms of Disease and Toxicity (Q-TWiST) Analysis of CPX-351 Versus 7+3 in Older Adults with Newly Diagnosed High-Risk/Secondary Acute Myeloid Leukemia (AML)

Blood, 2020
Introduction: CPX-351 (Vyxeos®; daunorubicin and cytarabine liposome for injection), a dual-drug liposomal encapsulation of daunorubicin and cytarabine in a synergistic 1:5 molar ratio, has been approved by the US FDA and the EMA for the treatment of ...
J. Cortes, Tara L. Lin, G. Uy, R. Ryan, S. Faderl, J. Lancet   +5 more
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The anti-lung cancer effect of ethyl acetate extract from Wenxia Formula in vivo via the Hedgehog-Gli1 signaling pathway mediated by cancer associated fibroblasts

, 2020
Introduction Lung cancer is one of the most common malignancies in the world. In 2012, a total of 1.8 million new cancer cases and 1.6 million related deaths were reported worldwide [1]. Approximately 10–15% of lung canMeng Wang, Qian-Yu Bi, Ya-Nan Zhang,
Meng Wang, Bi Qianyu, Ya-Nan Zhang, Xuming Ji   +3 more
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Gene Editing and Synthetic Biology

Advanced Biosystems, 2018
Prof. G. Q. Chen Center for Synthetic and Systems Biology School of Life Sciences Tsinghua University Beijing 100084, China E-mail: chengq@mail.tsinghua.edu.cn Synthetic biology, which relies on the design and construction of genetic parts as well as ...
Guoqiang Chen
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Molecular Diversity of Microbes with Probable Degradative Genes in Agricultural Soil Contaminated with Bonny Light Crude Oil

, 2016
This study looked at the diversity of microorganisms persistent in agricultural soil sample polluted with 100 ml of 100% Nigerian Bonny light crude oil left for four years.
T. Ogbulie, Nwaokorie Fo
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The Electrochemistry of Fe3O4/Polypyrrole Composite Electrodes in Lithium-Ion Cells: The Role of Polypyrrole in Capacity Retention

, 2017
Two series of magnetite (Fe3O4) composite electrodes, one group with and one group without added carbon, containing varying quantities of polypyrrole (PPy), and a non-conductive polyvinylidene difluoride (PVDF) binder were constructed and then analyzed ...
A. Bruck, Cara N. Gannett, D. Bock, Paul F. Smith, A. Marschilok, K. Takeuchi, E. Takeuchi   +6 more
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Correction: In Vitro and In Vivo Metabolism and Inhibitory Activities of Vasicine, a Potent Acetylcholinesterase and Butyrylcholinesterase Inhibitor

PLoS ONE, 2015
Vasicine (VAS), a potential natural cholinesterase inhibitor, exhibited promising anticholinesterase activity in preclinical models and has been in development for treatment of Alzheimer’s disease.
Wei Liu, Xiaoyuan Shi, Yadi Yang, Xuemei Cheng, Qing Liu, Han Han, Baohua Yang, Chunyong He, Yongli Wang, Bo Jiang, Zhengtao Wang, Changhong Wang   +11 more
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