Results 1 to 10 of about 3,898,656 (218)

Binary pan-cancer classes with distinct vulnerabilities defined by pro- or anti-cancer YAP/TEAD activity

open access: yesCancer Cell, 2021
SUMMARY Cancer heterogeneity impacts therapeutic response, driving efforts to discover over-arching rules that supersede variability. Here, we define pan-cancer binary classes based on distinct expression of YAP and YAP-responsive adhesion regulators ...
J. Pearson   +25 more
semanticscholar   +1 more source

Population of Merging Compact Binaries Inferred Using Gravitational Waves through GWTC-3 [PDF]

open access: yesPhysical Review X, 2021
We report on the population properties of compact binary mergers inferred from gravitational-wave observations of these systems during the first three LIGO-Virgo observing runs.
The Ligo Scientific Collaboration   +499 more
semanticscholar   +1 more source

Polynomial bounds for centered colorings on proper minor-closed graph classes [PDF]

open access: yesACM-SIAM Symposium on Discrete Algorithms, 2018
For $p\in \mathbb{N}$, a coloring $\lambda$ of the vertices of a graph $G$ is {\em{$p$-centered}} if for every connected subgraph~$H$ of $G$, either $H$ receives more than $p$ colors under $\lambda$ or there is a color that appears exactly once in $H ...
Michał Pilipczuk, S. Siebertz
semanticscholar   +1 more source

Comprehensive molecular portraits of human breast tumors

open access: yesNature, 2012
We analysed primary breast cancers by genomic DNA copy number arrays, DNA methylation, exome sequencing, messenger RNA arrays, microRNA sequencing and reverse-phase protein arrays.
D. Koboldt   +341 more
semanticscholar   +1 more source

Genomic Classification and Prognosis in Acute Myeloid Leukemia

open access: yesNew England Journal of Medicine, 2016
Background Recent studies have provided a detailed census of genes that are mutated in acute myeloid leukemia (AML). Our next challenge is to understand how this genetic diversity defines the pathophysiology of AML and informs clinical practice.
E. Papaemmanuil   +26 more
semanticscholar   +1 more source

An integrated map of structural variation in 2,504 human genomes

open access: yesNature, 2015
Structural variants are implicated in numerous diseases and make up the majority of varying nucleotides among human genomes. Here we describe an integrated set of eight structural variant classes comprising both balanced and unbalanced variants, which we
Peter Sudmant   +81 more
semanticscholar   +1 more source

Evolutionary classification of CRISPR–Cas systems: a burst of class 2 and derived variants

open access: yesNature Reviews Microbiology, 2019
The number and diversity of known CRISPR–Cas systems have substantially increased in recent years. Here, we provide an updated evolutionary classification of CRISPR–Cas systems and cas genes, with an emphasis on the major developments that have occurred ...
K. Makarova   +25 more
semanticscholar   +1 more source

Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature

open access: yesNatural product reports (Print), 2013
This review presents recommended nomenclature for the biosynthesis of ribosomally synthesized and post-translationally modified peptides (RiPPs), a rapidly growing class of natural products.
P. Arnison   +64 more
semanticscholar   +1 more source

Prospects for fundamental physics with LISA [PDF]

open access: yesGeneral Relativity and Gravitation, 2020
In this paper, which is of programmatic rather than quantitative nature, we aim to further delineate and sharpen the future potential of the LISA mission in the area of fundamental physics.
E. Barausse   +320 more
semanticscholar   +1 more source

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