Results 21 to 30 of about 25,940,484 (219)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
[Report to W. P. Gannaway by P. M. Parks and M. H. Brumley, February 17, 1964 #1]
, 1964 Criminal intelligence report by P. M. Parks and M. H. Brumley regarding an interview with Eddie Piper. Piper, who worked at the Texas School Book Depository, stated that he saw Lee Harvey Oswald when he came in to work at 10 AM. He did not observe Oswald
Dallas (Tex.). Police Department.
core
Ubiquitination of secretory granules promotes their crinophagic degradation in Drosophila
FEBS Letters, EarlyView.Ubiquitination of secretory granules in Drosophila larval salivary glands is a critical molecular trigger for crinophagy, the lysosomal degradation of unreleased, or low‐quality granules. The E3 ubiquitin ligase Cnot4 is recruited to the surface of secretory granules to induce crinophagy.
Tamás Csizmadia +6 more
wiley +1 more source
Chern classes for coherent sheaves [PDF]
We present in this paper a construction of Chern classes for a coherent sheaf S on a complex manifold X. In fact we construct classes Cp(S) in H2p(X, C), depending only on the smooth equivalence class of the sheaf S. and analytic classes CAp(S) in Hp(
Green, Howard Ivor
core
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
, 2019 Major classes of repetitive sequences in GP-H-Genome (the concatenated M. ambigua genome covering approximately 0.1–0.3% of the whole genome).
Foyez Shams (8120216) +6 more
core +1 more source
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
[Report to W. P. Gannaway by M. H. Brumley and P. M. Parks, February 18, 1964 #3]
, 1964 Criminal intelligence report by M. H. Brumley and P. M. Parks regarding an interview with Roy Edward Lewis. Lewis, who worked at the Texas School Book Depository, stated that he knew Lee Harvey Oswald on sight but did not associate with him.
Dallas (Tex.). Police Department.
core