Results 41 to 50 of about 25,265,347 (168)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Multiplier transformations on $H^{p}$ spaces

open access: yes, 1998
The authors obtain some multiplier theorems on $H^p$ spaces analogous to the classical $L^p$ multiplier theorems of de Leeuw. The main result is that a multiplier operator $(Tf)^(x) = λ(x)f̂(x)$ $(λ ∈ C(ℝ^n))$ is bounded on $H^p(ℝ^n)$ if and only if the ...
Fan, Dashan, Chen, Daning
core  

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

open access: yesMolecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski   +10 more
wiley   +1 more source

[Report to W. P. Gannaway by M. H. Brumley and P. M. Parks, February 18, 1964 #3]

open access: yes, 1964
Criminal intelligence report by M. H. Brumley and P. M. Parks regarding an interview with Roy Edward Lewis. Lewis, who worked at the Texas School Book Depository, stated that he knew Lee Harvey Oswald on sight but did not associate with him.
Dallas (Tex.). Police Department.
core  

Some remarks on James-Schreier spaces. [PDF]

open access: yes, 2010
The James-Schreier spaces V_p, where p is a real number greater than or equal to 1, were recently introduced by Bird and Laustsen as an amalgamation of James' quasi-reflexive Banach space on the one hand and Schreier's Banach space giving a ...
András Zsák   +5 more
core   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

open access: yesMolecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski   +12 more
wiley   +1 more source

[Report to W. P. Gannaway by P. M. Parks and M. H. Brumley, February 17, 1964 #2]

open access: yes, 1964
Criminal intelligence report by P. M. Parks and M. H. Brumley regarding an interview with Eddie Piper. Piper, who worked at the Texas School Book Depository, stated that he saw Lee Harvey Oswald when he came in to work at 10 AM. He did not observe Oswald
Dallas (Tex.). Police Department.
core  

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

Letter from Jno. P. H. Wentworth to Wm. P. Dole with a letter from R. H. Ford, 1862

open access: yes, 2008
Enclosed the accounts of late H. L. Ford and a letter from R. H. Ford, administrator of H. L.
Wentworth, John P. H.
core  

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

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