Results 31 to 40 of about 10,706 (218)

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

(p,q)-Baskakov-Kantorovich Operators

, 2016
In the last decade the applications of quantum calculus in the field of approximation theory is an active area of research. The (p,q)-calculus is further extension of q-calculus, which provides a new direction for researchers.
Gupta, Vijay
core   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

The Complex Line (P, Q)-Integral And (P, Q)-Green's Formula

, 2023
In this study, we present the complex line (p, q)-integral and multiple (p, q)-integral by using the concept of (p, q)-calculus. The (p, q)-Green's formula and the (p, q)-Gauss formulas are obtained with appropriate conditions in a complex ...
Gençtürk, İlker, Koca, Kerim
core   +1 more source

Gama Tipi Operatörün (p, q)-tamsayı İkililerine Dayalı Yaklaşım Özellikleri [PDF]

, 2022
In the literature; extensive work on the q and (p,q)-calculus has contributed greatly to describing the different generalizations of many operators involving the q and (p,q)-integers.
Karabıyık, Ümit, Ümit KARABIYIK
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Estimates for Certain Integral Inequalities on (p, q)-calculus

, 2020
The aim of this paper is to derive a new quantum analogue of an integral identity by using (p, q)-calculus. As a consequence of this identity, some new estimates for Ostrowski type inequality for (p, q)- differentiable η-convex and η-quasi-convex
Muhammad Amer Latif; Department of Basic Sciences, Deanship of Preparatory Year, University of Hail Hail2440, Saudi Arabia, Humaira Kalsoom; School of Mathematical Sciences, Zhejiang University, Hangzhou 310027, PR-China., Sabir Hussain; Department of Mathematics,University of Engineering and Technology, Lahore, Pakistan, Gullnaz Shahzadi; Department of Mechanical Engineering, Ecole de Technologie Superieure, 1100Notre-Dame W, Montreal, QC H3C 1K3, Canada   +3 more
core  

Relations Between the Fractional Operators in q-Calculus

, 2020
In this survey paper, we will consider the fractional operators in q-calculus. Starting from the fractional versions of q-Pochhammer symbol, we generalize the notions of the fractional q-integral and q-derivative by introducing variable lower bound of ...
Sergei Silvestrov, Sladjana D. Marinković, Miomir S. Stanković, Silvestrov, Sergei,, Rajković, Predrag,, Predrag M. Rajković, Marinković, Sladjana,, Stanković, Miomir,   +7 more
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source