Results 31 to 40 of about 24,477,475 (197)

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

open access: yesMolecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi   +6 more
wiley   +1 more source

p-OPERATOR SPACE STRUCTURE ON FEICHTINGER-FIGA-TALAMANCA-HERZ SEGAL ALGEBRAS

open access: yes, 2015
We consider the minimal boundedly-translation-invariant Segal algebra S-0(p)(G) in the Figa-Talamanca-Herz algebra A(p) (G) of a locally compact group G. In the case that p = 2 and G is abelian this is the classical Segal algebra of Feichtinger. Hence we
Spronk, Nico, Oztop, Serap
core   +1 more source

Operator valued Dirichlet problem in the plane [PDF]

open access: yes, 2012
We consider an operator valued Dirichlet problem for harmonic mappings and prove the existence of a Perron-like solution. To formulate the Perron’s construction we make use of Olson’s notion of spectral order.
Göğüş, Nihat Gökhan
core   +3 more sources

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

open access: yesMolecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

On weak-starp-convergent operators

open access: yes, 2017
The purpose of this article is to introduce and study the notion of “weak* p-convergent operator”. We discuss the relationship between the weak* p-convergent operators and the p-convergent operators, a class of operators that was introduced in the paper [
Fourie, Jan H.   +3 more
core   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

open access: yesMolecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim   +7 more
wiley   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

open access: yesMolecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez   +5 more
wiley   +1 more source

Convergent multiples of convergent operators [PDF]

open access: yes, 1999
Let “X≫0” mean that “the bounded linear Hilbert-space operator X is selfadjoint, positive, and invertible”. We discuss the operators A which are known to be convergent (i.e. have spectral radius less than 1) because they all satisfy Stein's condition P−A∗
Bryan E. Cain, Cain, Bryan E.
core   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

Fourier integrals and a new representation of Maslov's canonical operator near caustics [PDF]

open access: yes, 2013
We suggest a new representation of Maslov's canonical operator in a neighborhood of the caustics using a special class of coordinate systems (\eikonal coordinates") on Lagrangian ...
Dobrokhotov, Sergey   +2 more
core  

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